Pandemi Servisinde Yatan Kovid-19 Hastalarında Aşılanma Durumunun Prognoza Etkisinin Araştırılması

Öz

Amaç: Hastanede yatış sırasında değişen aşı kombinasyonları ile aşı durumunun COVID-19 hastalarının prognozuna etkisini değerlendirmeyi amaçladık. Materyal ve Metot: Araştırma 457'si kadın olmak üzere 854 COVİD-19 hastasının verileriyle gerçekleştirildi. Karşılaştırmalarda yer alan bağımlı değişken yoğun bakım ihtiyacı, bağımsız değişkenler; cinsiyet, risk skoru, şiddet skoru, aşılanma durumlarıdır. Bulgular: Hastaların yaş ortalaması 57,7±15,71 standart sapma (SS) yıl olup, %49,2’si hiç aşı olmamış ve %18,3’ününde yoğun bakım ihtiyacı olmuştur. Hastaların. Farklı aşı kombinasyonları kullanılarak üç lojistik regresyon modeli oluşturulmuştur. İlk modelde üç doz CoronaVac ya da iki doz CoronaVac bir doz Comirnaty aşısı, ikinci modelde üç doz CoronaVac aşısı, son modelde sadece aşı olmanın (hastalık öncesi 6 ayda en az bir doz) yoğun bakım ünitesi (YBÜ)’ne yatış riskini sırasıyla %82, %77 ve %42’lik azalma sağladığı saptanmıştır. Sonuç: Aşılamanın yatan hastalarda yoğun bakım ihtiyacını önlemedeki etkinliği bir kez daha ortaya kondu ve rapel aşı dozlarıyla bu etkinliğin daha da arttığı gözlendi.

Anahtar Kelimeler

• COVID-19
• COVID-19 aşıları
• yatan hastalar
• yoğun bakım

Investigation of the Effect of Vaccination Status on the Prognosis of Covid-19 Patients Hospitalized in Pandemic Service

Öz

Objective: We aimed to evaluate the effect of vaccination status on the prognosis of COVID-19 patients with varying vaccine combinations during hospitalization Materials and Methods: The study was conducted with the data of 854 COVID-19 patients, of which 457 were female. The dependent variable in the comparisons was the need for intensive care, and the independent variables were gender, risk score, severity score, and vaccination status. Results: The mean age of the patients was 57.7±15.71 with standard deviation (SD); 49.2% had never been vaccinated, and 18.3% needed intensive care. Three logistic regression models were developed using different vaccine combinations. Three doses of CoronaVac or two doses of CoronaVac and one dose of Comirnaty vaccine in the first model, three doses of CoronaVac vaccine in the second model, and receiving the vaccine solely (at least one dose in the 6 months before the disease) in the last model were found to reduce the risk of intensive care unit (ICU) admission by 82%, 77%, and 42%, respectively. Conclusion: The effectiveness of vaccination in preventing the need for intensive care in inpatients was once again demonstrated, and it was observed that this effectiveness increased even more with booster vaccine doses.

Anahtar Kelimeler

• COVID-19
• COVID-19 Vaccines
• Inpatients
• Intensive care

Kaynakça

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