Yenidoğan Yoğun Bakım Ünitesinde Tiroid Dışı Hastalık Sendromu

Öz

Amaç: Bu çalışmanın amacı yenidoğanlarda tiroid dışı hastalık sendromunun (TDHS) yaygınlığını belirlemek ve yenidoğan sonuçları üzerindeki potansiyel etkilerini araştırmaktır. Ayrıca, TDHS gelişimi ile ilişkili risk faktörlerini belirleyerek, sendromun daha iyi anlaşılmasına katkıda bulunmak amaçlanmaktadır. Materyal ve Metot: Yenidoğan yoğun bakım ünitesinde yatan 337 hastanın verileri retrospektif olarak toplandı. Gebelik yaşı, doğum ağırlığı, Apgar skoru, SNAPPE skoru, doğum şekli, konjenital anomaliler, solunum desteği ve hastanede yatış süresi gibi demografik ve klinik veriler toplanmıştır. Tüm hastalarda tiroid uyarıcı hormon (TSH) ve serbest tiroksin (sT4) düzeyleri ölçülmüştür. Bulgular: Çalışmaya alınan hastaların %4,5’inde TDHS saptanmıştır. TDHS tanısı alan hastalar, daha düşük gebelik haftası, doğum ağırlığı, baş çevresi, boy, ve Apgar skorlarına sahipti. TDHS hastalarının hastane yatış süreleri anlamlı şekilde daha uzun bulunmuş, ancak mekanik ventilasyon süresi ve SNAPPE skorlarında fark gözlenmemiştir. Sonuç: Bu çalışma, kritik hastalık geçiren yenidoğanlarda tiroid fonksiyon bozukluklarının görülebileceğini ve bu grubun tiroid fonksiyonlarının değerlendirilmesinin önemli olduğunu göstermektedir.

Anahtar Kelimeler

• Tiroid dışı hastalık sendromu
• tiroid fonksiyon testleri
• tiroid taraması
• ötiroid hasta sendromu
• yenidoğan yoğun bakım ünitesi

Non-Thyroidal Illness Syndrome in Neonatal Intensive Care Units

Abstract

Objective: This study aims to establish the incidence of non-thyroidal illness syndrome (NTIS) in newborns and investigate its potential impact on neonatal outcomes. Additionally, by identifying the risk factors associated with the development of NTIS, this study aims to deepen the understanding of the condition. Materials and Methods: A total of 337 patients in the neonatal intensive care unit were studied retrospectively. Data on demographic and clinical characteristics, including gestational age, birth weight, head circumference, height, Apgar score, SNAPPE score, presence of congenital anomalies, mode of delivery, respiratory support, and duration of hospitalization, were collected. All patients underwent measurement of TSH and free T4 levels. Results: The study found that 4.5% of patients were diagnosed with NTIS. Patients with NTIS had higher rates of preterm delivery. NTIS patients exhibited lower gestational age, birth weight, head circumference, height, and Apgar scores than non-NTIS patients. NTIS patients had significantly more extended hospital stays, but no differences in mechanical ventilation duration or SNAPPE scores were obtained. Conclusions: This study indicates that thyroid dysfunction can occur in critically ill newborns, highlighting the necessity of evaluating thyroid function in this demographic.

Keywords

• Euthyroid sick syndrome
• neonatal intensive care unit
• non-thyroidal illness syndrome
• thyroid function tests
• thyroid screening

Kaynakça

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