Mide Kanserinde Halp Skoru, LCR Değeri ve CRP-Albumin Oranının Sağkalım ve Nüks için Öngörücü Rolü

Öz

Amaç: Hemoglobin, albumin, lenfosit ve trombosit (HALP) skoru, lenfosit-C-reaktif protein oranı (LCR) ve CRP/Albumin oranı gibi biyokimyasal belirteçlerin oranlarının mide kanseri hastalarında hastalığın sağ kalımını ve tekrarını tahmin edip edemeyeceğini araştırmak. Materyal ve Metot: Ocak 2014 ile Aralık 2023 tarihleri ​​arasında kliniğimizde mide kanseri nedeniyle opere edilen yetişkin hastalar (n: 85) bu retrospektif çalışmaya dahil edildi. Hastaların preoperatif biyokimyasal verilerinden HALP ve CRP/Albumin skorları ve LCR oranları hesaplandı. Bulgular: Düşük HALP skorlu hastaların genel sağ kalım süresi, yüksek HALP skorlu hastalara göre anlamlı derecede daha kısaydı (30.6'ya karşı 35.5 ay) (p<0,05). Ayrıca, düşük LCR oranına sahip hastaların genel sağ kalım süresi, yüksek LCR skorlu hastalara göre anlamlı derecede daha kısaydı (27.9'a karşı 35.6 ay, p<0,05) ve benzer şekilde, düşük CRP/Albumin değerine sahip hastaların genel sağ kalımı, yüksek CRP/Albumin değerine sahip hastalara göre anlamlı derecede daha kısaydı (29.9'a karşı 32.4 ay) (p<0,05). HALP, LCR ve CRP/Albumin skorları ile tekrarlama arasında güçlü bir korelasyon vardı (her biri için p<0,05). Çok değişkenli Cox regresyon analizinin sonuçlarına göre, HALP skoru, LCR skoru ve CRP/albumin oranının genel sağ kalım için bağımsız ve pozitif faktörler olduğu bulundu (p<0,05). Sonuç: HALP, LCR ve CRP/Albumin skorlarından herhangi birinde düşük skorlar, mide kanseri olan hastalarda düşük postoperatif genel sağ kalım ve nüks ile ilişkiliydi.

Anahtar Kelimeler

• Biyobelirteçler
• mide kanseri
• prognoz
• nüks

Predictive Role of Halp Score, LCR Value and CRP-Albumin Ratio for Survival and Recurrence in Gastric Cancer

Abstract

Objective: To investigate whether the ratios of biochemical markers such as hemoglobin, albumin, lymphocyte and platelet (HALP) score, lymphocyte-C-reactive protein ratio (LCR) and CRP/Albumin ratio can predict the survival and recurrence of the disease in gastric cancer patients. Materials and Methods: Adult patients who were operated for gastric cancer in our clinic between January 2014 and December 2023 (n: 85) were included in this retrospective study. HALP and CRP/Albumin scores and LCR ratios were calculated from the preoperative biochemical data of the patients. Results: Overall survival of patients with a low HALP score was significantly shorter than that of patients with a high HALP score (30.6 vs 35.5 months) (p<0.05). In addition, overall survival of patients with low LCR rate was significantly shorter than that of patients with high LCR score (27.9 vs 35.6 months, p<0.05), and similarly, the overall survival of patients with low CRP/Albumin value was significantly shorter than that of patients with high CRP/Albumin value (29.9 months vs 32.4 months) (p<0.05). There was a strong correlation between HALP, LCR, and CRP/Albumin scores and recurrence (for each p<0.05). According to the results of multivariate Cox regression analysis, HALP score, LCR score and CRP/albumin ratio were found to be independent and positive factors for overall survival (p<0.05). Conclusions: Low scores in any of the HALP, LCR, and CRP/Albumin scores were associated with poor postoperative overall survival and recurrence in patients with gastric cancer.

Keywords

• Biomarkers
• gastric cancer
• prognosis
• recurrence

Kaynakça

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