Use of Biological Agents in Rheumatology

Abstract

The advances in molecular biology have led to a variety of new treatment approaches for rheumatological diseases. The better understanding of the pathogenesis of rheumatological diseases has yielded new therapeutic targets. With the usage of biological agents in clinical practice the goal remission in rheumatic diseases has became a more realistic target. In this article we will share the mechanisms of action, clinical uses, efficacy and safety of biologic agents increasingly used in recent years in rheumatic diseases.

Keywords

• Biological agents,cytokines,T-lymphocytes,B-lymphocytes

Romatolojide Biyolojik Ajanların Kullanımı

Öz

Moleküler biyoloji alanında yaşanan gelişmeler romatolojik hastalıkların tedavisi için yeni yaklaşımların önünü açmıştır. Romatolojik hastalıkların patogenezlerinin daha iyi anlaşılması tedavide yeni hedefler ortaya çıkmasını sağlamıştır. Biyolojik ajanların kullanıma girmesi ile birçok romatolojik hastalığın tedavisinde remisyon artık daha gerçekçi bir hedef gibi görülmektedir. Biz bu yazıda, romatolojik hastalıklarda son yıllarda kullanımı giderek artan biyolojik ajanların etki mekanizmaları,klinik kullanımları, etkinlik ve güvenlik verilerini paylaşacağız.

Anahtar Kelimeler

• Biyolojik ajanlar,sitokinler,T-lenfositler,B-lenfositler

Kaynakça

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