Comparison Of Endometrial Pathology Results in Tamoxifen Or Tamoxıfen+Leuprolid Acetate Therapy in Breast Cancer Women

Abstract

The effects of addition of GnRH agonist on endometrial pathology and endometrial cancer rates in tamoxifen use in breast cancer patients. A retrospective study of 204 patients who were operated for breast cancer between 1998 and 2013 and who underwent endometrial sampling at the gynecology clinic of Trakya University Medical Faculty, were divided into two group as treatment with tamoxifen and tamoxifen+GnRH agonist(leuprolide acetate depot 11.25 mg ). There were no differences between the groups in terms of endometrial thickness in the ultrasound examination, endometrial pathology in the histopathological examination and incidence of endometrial cancer among the premenopausal women using tamoxifen+GnRH and the the postmenopause women using tamoxifen. We found that the addition of a GnRH analog to the treatment of tamoxifen in breast cancer patients did not increase the risk of premalignant lesion and endometrium ca in premenopausal women.

Keywords

• Breast cancer,tamoxifen,GnRH analgesic,leuprolide acetate,endometrial pathology,endometrial cancer

Meme Kanserli Kadınlarda Tamoksifen veya Tamoksifen+Leuprolid Asetat Tedavisi Alanlarda Endometrial Patoloji Sonuçlarının Karşılaştırılması

Öz

Meme kanserli olgularda tamoksifen kullanımına GnRH agonisti eklenmesinin endometrial patoloji ve endometrial kanser oranlarına etkisinin araştırılması planlandı. Retrospektif yapılan çalışma 1998 ile 2013 yılları arasında meme kanseri nedeniyle opere olan ve Trakya Üniversitesi Tıp Fakültesi Hastanesi jinekoloji polikliniğinde endometriyal örnekleme yapılan 204 olgu, sadece tamoksifen alanlar ve tamoksifen+GnRH agonisti(leuprolide acetate depot 11,25 mg) tedavisi alanlar olarak iki gruba ayrıldı. Tamoksifen ile birlikte GnRH agonisti kullanan premenopozal kadınlar ile tamoksifen kullanan postmenopozal kadınlar arasında ultrason incelemesinde endometrial kalınlık, histopatolojik incelemede endometrial patoloji bulunma ve endometrial kanser görülme oranları açısından gruplar arasında fark bulunmadı. Meme kanserli hastalarda tamoksifen tedavisine GnRH anoloğunun eklenmesi premenopozal kadınlarda premalign lezyon ve endometrium ca riskini arttırmadığını saptadık.

Anahtar Kelimeler

• Meme kanseri,tamoksifen,GnRH analoğu,leuprolid asetat,endometrial patoloji,endometrial kanser

Kaynakça

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