Artmış Lipid Seviyeleri ve Meme Kanseri

Öz

Meme kanseri, hem gelişmiş hem de gelişmekte olan ülkelerde kadınlarda görülen en sık kanserdir. Metabolik heterojenite tüm kanserlerde mevcut olabilir. Dislipidemi, bağımsız olarak meme kanseri gelişimi ile ilişkilidir. Bu çalışma, çalışma grubundaki 100 meme kanseri hastasından ve kontrol grubu olarak adlandırılan 100 benzer normal kadınlardan alınan serum örnekleri üzerinde yapıldı. Herhangi bir tedavi uygulamadan önce çalışma grubu ve kontrol grubu üzerinde lipit paterni çalışmaları yapıldı. Toplanan serum örnekleri Total kolesterol (TC), HDL, LDL ve Trigliserit konsantrasyonları açısından incelenmiştir. Çalışma grubunda en genç hasta 35 yaşında, en yaşlı hasta 83 yaşında idi. Ortalama yaş 58,41 ± 11,01 yıldı. Kontrol grubunda en genç hasta 30 yaşındaydı ve en yaşlı hasta 80 yaşındaydı. TC, LDL, TG seviyeleri bütün evrelerde artmış olarak bulundu ve C-ERB-B2 pozitifliğinde de benzer olan artmıştır. Çalışmamız lipid düzeyleri ile meme kanseri arasındaki ilişkiyi desteklemektedir. Bununla birlikte, bir marker olarak kullanılmak üzere, prospektif de dahil olmak üzere çoklu merkez çalışmalarına ihtiyaç duyulmaktadır.

Anahtar Kelimeler

• Lipid düzeyi,Meme Kanseri

Increased Lipids Levels and Breast Cancer

Abstract

Breast cancer is the top cancer in women both in the developed and the developing world. Metabolic heterogeneity may be present in all cancers. Dyslipidemia is independently associated with the development of breast cancer. The present study was carried out on serum samples from 100 breast cancer patients named study group and 100 similar age normal women named control group. Lipid pattern studies were carried out on study group and control group before any treatment. The   serum   samples   so   collected   were   examined   for   Total cholesterol  (TC),  High  density  lipoprotein  cholesterol  (HDL),  Low density  lipoprotein  cholesterol  (LDL) and  Triglyceride  (TG)  concentrations. In the study group the youngest patient was of 35 years old and oldest patient was of 83 years. Mean age was 58.41±11.01 years. In the control group, the youngest patient was of 30 years and oldest patient was of 80 years. TC, LDL, TG levels increased in all grades, which is similar in the of C-ERB-B2 positive status. Our study supports the relationship between increased lipid levels and breast cancer. However, there is a need for multiple center studies, including prospective, to be used as a marker.

Keywords

• Lipid level,Breast cancer

Kaynakça

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