Serum Lipid Profile in Patients with Cholelithiasis

Öz

This research aims to correlate status of lipid profile in the patients diagnosed with cholelithiasis. It is an observational case control study, completed in the Biochemistry department of Tribhuvan University and Teaching Hospital (TUTH). Total 100 subjects were selected and divided in two groups. The groups consisted of 50 patients with cholelithiasis (group A) and 50 healthy control groups (group B). The research was completed within a time of eight months commencing from 1st March 2016 to 31st October 2016.  Confirmation of cholelithiasis was performed with ultrasound studies by radiologist. Selection of group A and group B were done on basis of radiological findings. Fasting blood samples for lipid profiles of all subjects were collected and lipid profile tests done in bio-chemistry lab. Self-designed form was used for documentation of different parameters of subjects. Triglyceride (TG) and High-Density Lipids (HDL) were found to be statically significant (p=0.005 and p=0. 001, respectively). Mean TG level in patients with cholelithiasis (1.9 mmol/l) was found higher than in normal cases (1.45 mmol/l). Mean HDL level in patients (0.95 mmol/l) was lower than normal cases with (1.05mmol/l). In conclusion, we think that lipid profiles altered in patients with cholelithiasis.

Anahtar Kelimeler

• Cholelithiasis,total cholesterol,triglyceride,high density lipid,low density lipid

Kolelitiazisli Hastalarda Serum Lipit Profili

Öz

Bu araştırma, kolelitiazis tanısı alan hastalarda lipid profili durumunu ilişkilendirmeyi amaçlamaktadır. Biyokimya Anabilim Dalı'nda tamamlanmış bir gözlemsel vaka kontrol çalışmasıdır. Toplam 100 denek seçildi ve iki gruba ayrıldı. Gruplar kolelitiazisli 50 hasta (grup A) ve 50 sağlıklı kontrol gruptan (grup B) oluşmaktaydı.  Araştırma, 1 Mart 2016 ile 31 Ekim 2016 tarihleri ​​arasında sekiz ay içinde tamamlandı. Kolelitiazisin doğrulanması Radyolog tarafından ultrason çalışmaları ile gerçekleşmiştir. Grup A ve grup B seçimi radyolojik bulgulara dayanarak yapıldı. Tüm olguların lipit profilleri için açlık kan örnekleri toplandı ve lipit profil testleri biyokimya laboratuarında yapıldı. Olguların farklı parametrelerinin belgelenmesi için öz-tasarımlı form kullanıldı. Trigliserit (TG) ve Yüksek Yoğunluklu Lipidler (HDL) istatistiksel olarak anlamlı bulundu. (Sırasıyla, p = 0,005 ve p = 0,001). Safra taşı olan hastalarda ortalama TG seviyesi (1,9 mmol / l) normal olgulardan (1,45 mmol / l) daha yüksek bulundu. Hastalarda ortalama HDL düzeyi (0,95 mmol / l) normal olgulardan (1,05 mmol / l) düşüktü. Sonuç olarak kolelitiazisli hastalarda lipit profillerinin değiştiğini düşünmekteyiz.

Anahtar Kelimeler

• Kolelitiazis,total kolesterol,trigliserit,yüksek yoğunluklu lipid,düşük yoğunluklu lipid

Kaynakça

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