Non Alkolik Yağlı Karaciğer Hastalığı ile Yaş, Cinsiyet ve İnsülin Direnci İlişkisinin Araştırılması

Yıl 2021, , 291 - 299, 05.06.2021

Hayrullah Yazar , Ömer Emre Öz , Elif Köse , Alper Karacan , Mustafa Yöntem

https://doi.org/10.26453/otjhs.898531

Öz

Amaç: Bu çalışmada non-alkolik yağlı karaciğer hastalarında (NAYKH) insülin direnci, yaş ve cinsiyet ilişkisinin araştırılması amaçlanmıştır.
Materyal ve Metot: NAYKH tanılı alkol kullanmayan hastalara ait veriler, bir yıl boyunca kayıt altına alındı. Hastaların NAYKH tanısı 4D ultrason cihazı ile konuldu. Çalışmada tüm hastaların açlık kan şekeri ve açlık insülin hormonu değerleri kullanılarak, insülin dirençleri hesaplandı. Elde edilen verilerin istatistiği “IBM SPSS for Windows Version 20.0 software” programı ile yapıldı ve anlamlılık düzeyi p<0,05 kabul edildi.
Bulgular: Çalışmada; kriterlere uyan 312 erkek ve 558 kadın, toplamda 870 hasta incelendi. Erkeklerde yaş ortalaması 15, kadınlarda 29 bulundu ve bu farkın anlamlı olduğu görüldü. NAYKH görülme sıklığı; erkeklerde %47,75 iken, kadınlarda %33,51 oldu. Yaşa göre NAYKH; çocuklarda %32,57 iken, erişkinlerde %49,28 şeklinde idi. HOMA-IR ortalama değerleri cinsiyete göre; erkeklerde 2,51 ve kadınlarda 2,53 idi. Yaşa göre HOMA-IR ortalama değerleri; çocuklarda 3,14 ve erişkinlerde 2,09 bulundu. HOMA-IR grade guplarına göre incelenince, bu değerlerin grade II ve grade III’te anlamlı olarak arttığı görüldü.
Sonuç: NAYKH, yaş ve cinsiyet arasında ilişki vardır. Şöyle ki; erkeklerde bu hastalık hem sık görülmekte hem de erken yaşta ortaya çıkmaktadır. İlaveten; HOMA-IR’nin çocuklarda daha yüksek çıkması, üzerinde daha geniş çaplı araştırma yapılması gereken bir sonuç olarak görüldü.

Anahtar Kelimeler

NAYKH, Homa-IR, 4D doppler usg, yaş, cinsiyet

Investigation of the Relationship between Non-Alcoholic Fatty Liver Disease and Age, Gender and Insulin Resistance

Öz

Objective: In the study, it was aimed to investigate of insulin resistance, age, and gender relationship in non-alcoholic fatty liver disease (NAFLD).
Materials and Methods: The data of patients diagnosed with NAFLD who did not drink alcohol were recorded for one year. The patients were diagnosed with NAFLD with Doppler USG and divided into three groups. In the study, insulin resistance was calculated using fasting blood glucose and fasting insulin hormone values of all patients. The statistics of the obtained data were made using the program "IBM SPSS for Windows Version 20.0" and the significance level was accepted as p <0.05.
Results: In the study; A total of 870 patients, 312 males and 558 females, who met the criteria were examined. The average age was 15 for males and 29 for females, and this difference was found to be significant. Incidence of NAFLD; While it was 47.75% for men, it was 33.51% for women. NAFLD by age; While it was 32.57% in children, it was 49.28% in adults. HOMA-IR average values; 2.51 in male patients and 2.53 in women. HOMA-IR average values by age; 3.14 in children and 2.09 in adults. When the HOMA-IR values were examined according to the grade groups, it was seen that these values increased significantly in grade II and grade III.
Conclusion: There is a relationship between NAFLD, age and gender. Namely, This disease is common in men and occurs at an early age. Additionally, the higher HOMA-IR in children was seen as a result that should be researched more widely.

Anahtar Kelimeler

NAFLD, Homa-IR, 4d doppler usg, age, gender

Kaynakça

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