İlk Trimester Serum Lipid Profili ile Postterm Gebelik İlişkisi

Öz

Amaç: Çalışmada ilk trimesterdeki lipid profili ile postterm gebelik (PTG) arasındaki ilişkiyi ve lipid profilinin PTG için bir öngörü kriteri olup olamayacağını değerlendirmeyi amaçladık.

Materyal ve Metot: Çalışmaya postterm dönemdeki 329 (vaka grubu) ve term dönemdeki 97 (kontrol grubu) gebe dahil edildi. Hastaların demografik bilgileri, doğum şekilleri, ilk trimester lipid profilleri (total kolesterol, trigliserid, HDL-K, LDL-K, VLDL-K düzeyleri) ile doğan bebeklerin APGAR skoru ve yenidoğan yoğun bakım (YDYB) kabulu kaydedildi. Çalışmada gruplar arasındaki lipid profil farklılıkları değerlendirildi.

Bulgular: Gruplar arasında yaş, gebelik sayısı, parite ve vücut kitle indeksi (VKI) açısından anlamlı farklılık saptanmazken, ortalama APGAR skorları (p<0,001) ve YDYB ihtiyacı (p<0,001) açısından anlamlı farklılık tespit edildi. PTG grubunda sezaryen (C/S) olma oranı term gruba göre daha yüksekti ve fark istatistiksel olarak anlamlı bulundu (p<0,001). Gruplar arasında lipid profilleri değerlendirildiğinde; total kolesterol, trigliserid, HDL-K, LDL-K ve VLDL-K düzeylerinin PTG grubunda anlamlı olarak daha düşük olduğu saptandı (p<0,05).

Sonuç: Çalışmada, ilk trimester lipid düzeyi düşüklüğü ile PTG arasında anlamlı bir ilişki tespit edildi. Gebede ilk trimesterdeki düşük lipid seviyeleri, PTG’i öngörmek için bir kriter olarak değerlendirilebilir. Bununla beraber PTG’ye neden olabilecek başka faktörlerde bulunduğundan lipid profili ile PTG arasındaki ilişkinin daha iyi anlaşılabilmesi için destekleyici prospektif çalışmalara ihtiyaç vardır. 

Anahtar Kelimeler

• İlk trimester
• kolesterol
• lipid profili
• Postterm gebelik
• trigliserid

Relationship between Postterm Pregnancy and First Trimester Serum Lipid Profile

Abstract

Objective: In this study, we investigated the association between first trimester lipid profile and postterm pregnancy (PTG) and whether lipid profile can be a predictive criterion for the development of PTG.

Materials and Methods: 329 pregnant women with postterm delivery and 97 pregnant women with term delivery were included in the study. Demographic data, mode of delivery, first trimester lipid profiles (total cholesterol, triglyceride, HDL-C, LDL-C, VLDL-C), APGAR score of the babies born, and whether they required neonatal intensive care. In the study, the lipid profile differences between the groups were evaluated.

Results: While no significant difference was found between the postterm and term pregnancy groups in terms of age, number of pregnancies, parity, and body mass index (BMI), a statistically significant difference was found in terms of mean APGAR score (p < 0.001) and YDYB requirement (p < 0.001). The rate of cesarean section in PTG group was higher than in term pregnancies and the difference was statistically significant (p < 0.001). When the lipid profiles were evaluated between the groups, it was found that the levels of total cholesterol, triglyceride, HDL-C, LDL-C and VLDL-C levels were significantly lower in the PTG group (p < 0.05).

Conclusion: In our study, low lipid levels in the first trimester were found to be associated with PTG. Low lipid levels in the first trimester of pregnancy can be considered as a criterion for predicting PTG. However, because there are other factors that may cause PTG, supportive prospective studies are needed to better understand the relationship between lipid profile and PTG.   

Keywords

• First trimester
• cholesterol
• lipid profile
• postterm pregnancy
• triglyceride

Kaynakça

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