Use of Biological Agents in Rheumatology

Yıl 2017, Cilt: 2 Sayı: 2, 34 - 45, 30.06.2017

Simem Sağ Kemal Nas

Öz

The advances in molecular biology
have led to a variety of new treatment approaches for rheumatological diseases.
The better understanding of the pathogenesis of rheumatological diseases has
yielded new therapeutic targets. With the usage of biological agents in
clinical practice the goal remission in rheumatic diseases has became a more
realistic target. In this article we will share the mechanisms of action,
clinical uses, efficacy and safety of biologic agents increasingly used in
recent years in rheumatic diseases.

Anahtar Kelimeler

Biological agents, cytokines, T-lymphocytes, B-lymphocytes

Romatolojide Biyolojik Ajanların Kullanımı

Öz

Moleküler
biyoloji alanında yaşanan gelişmeler romatolojik hastalıkların tedavisi için
yeni yaklaşımların önünü açmıştır. Romatolojik hastalıkların patogenezlerinin
daha iyi anlaşılması tedavide yeni hedefler ortaya çıkmasını sağlamıştır.
Biyolojik ajanların kullanıma girmesi ile birçok romatolojik hastalığın
tedavisinde remisyon artık daha gerçekçi bir hedef gibi görülmektedir. Biz bu
yazıda, romatolojik hastalıklarda son yıllarda kullanımı giderek artan
biyolojik ajanların etki mekanizmaları,klinik kullanımları, etkinlik ve
güvenlik verilerini paylaşacağız.

Anahtar Kelimeler

Biyolojik ajanlar, sitokinler, T-lenfositler, B-lenfositler

Kaynakça

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