Akut Yetmezlikte Karaciğer Nakli; Tek Merkez Deneyimi

Yıl 2019, Cilt: 4 Sayı: 4, 519 - 525, 31.12.2019

Gokhan Ertugrul Tumay Yanaral

https://doi.org/10.26453/otjhs.563470

Cited By: 1

Öz

Akut karaciğer yetmezliği, ilerleyici
karaciğer disfonksiyonudur. Karaciğer nakli, etkin bir tedavi seçeneğidir. Bu
çalışmanın amacı akut karaciğer yetmezliği nedeniyle yapılan canlı vericili karaciğer
nakillerini değerlendirmektir.  Nisan 2014 ile Nisan 2019 tarihleri arasında,
Medipol Üniversitesi Tıp Fakültesi Hastanesi Organ Nakli Bölümü’nde akut
karaciğer yetmezliği nedeniyle canlı vericili karaciğer nakli yapılan 13 hasta
retrospektif olarak değerlendirildi. Hastaların
yaş ortalaması 21,1±20,9 yıldı. Hastaların dokuzu (%69,2) kadın ve yedisi   (%53,8) çocukluk (< 18 yıl) yaş grubunda
idi.  En sık toksik hepatit nedeniyle (%38,5)
karaciğer nakli yapıldı. Hastaların ortalama takip süresi 35,1±12,2 aydı.
Hastaların beşinde (%38,5) komplikasyon gelişti. Hastalardan dördünde (%30,7)  mortalite görüldü. Genel sağkalım oranı 1 ve
5 yıllık sırasıyla % 84,7 ve % 69,3 idi.
Akut yetmezlikte yapılan canlı vericili karaciğer nakillerinin başarılı olduğu
görünmektedir.

Anahtar Kelimeler

Akut karaciğer yetmezliği, karaciğer nakli, analiz

Destekleyen Kurum

Medipol Üniversitesi

Liver Transplantations in Acute Failure; A Single Center Experiences

Öz

Acute hepatic failure is progressive
liver dysfunction. Liver transplantation is an effective treatment option. The
aim of this study was to evaluate the living donor liver transplantation due to
acute liver failure. Between April 2014 and April 2019 at Medipol University
Medical Faculty Hospital Organ Transplantation Department, 13 patients with
living donor liver transplantations in acute failure was studied
retrospectively. The mean age of the patients was 21.1±20,9 years. Of these
patients, nine (69.2%) were female and seven (53.8%) were children (< 18
years old) . Liver transplantation was the most common cause of toxic hepatitis
(38.5%). The mean follow-up of the period was 35.1±12.2 months. Complications
were seen in five patients (38.5%). Mortality was observed in four patients (30.7%).
Overall survival rate was 84.7% and 69,3% in 1 and 5 years, respectively. Living
donor liver transplantation appears to be successful in acute failure.

Anahtar Kelimeler

Acute liver failure, liver transplantation, analysis

Kaynakça

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