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Sağlık Araştırmalarında Matematik Model Kullanımı

Yıl 2020, Cilt: 5 Sayı: 3, 528 - 540, 30.09.2020
https://doi.org/10.26453/otjhs.773674

Öz

Sağlık araştırmalarında matematik modellerin uygulanması yeni olmamakla beraber son yıllarda oldukça yaygınlaşmıştır. Bu artışın nedeni olarak veriyle hesaplama gücündeki artış kadar sağlık maliyetlerinin artması, kaynakların azalması bununla beraber artan yaşam süresi nedeniyle rastlanan kompleks sağlık sorunları da gösterilebilir. Bu çalışma, matematik modellerin sağlık alanındaki uygulamalarını incelemeyi amaçlamakta olup özellikle klinik uygulamaları ve hastalık modellerine önem vermiştir. Bulaşıcı hastalıklar ve kronik hastalıkların modellenmesi bunlara bağlı olarak tedavi ve korunma yöntemlerinin arasından en etkin ve maliyet etkili olanların belirlenmesi önemli bir alandır. Kızamık, grip, kanser ve HIV gibi birçok hastalık ve halk sağlığı sorunu matematik modeller yardımıyla incelenip var olan kaynakların etkin kullanımını sağlayacak karar destek çalışmaları mevcuttur. Bu çalışmada, bu çalışmaların geniş bir özeti kullanılan matematik modelleme yöntemlerinin sınıflandırılmasıyla verilmiştir. Hastalık model yöntemleri olarak Markov modeller, kompartıman modelleri ve ajan temelli benzetim modelleri metot olarak özetlenmiş ve yapılan önemli çalışmalardan bazıları ve Türkiye’de yapılan uygulamalar incelenmiştir.

Destekleyen Kurum

Destekleyen Kurum bulunmamaktadır.

Kaynakça

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Mathematical Models in Healthcare

Yıl 2020, Cilt: 5 Sayı: 3, 528 - 540, 30.09.2020
https://doi.org/10.26453/otjhs.773674

Öz

In the recent years, healthcare applications of mathematical models have been increasingly developed although the field of healthcare models is not a new area. Current trends could be explained with growing rate of data and computing skills, rising healthcare costs, decreasing resources as well as more complex health problems due to extended life expectancy. In this paper, we survey the mathematical models applied to healthcare problems with a focus on disease applications. Infectious and chronic disease modelling which has been studied for several diseases such as measles, influenza is an important research area. Furthermore, effectiveness and cost-effectiveness of prevention, screening and treatment interventions could be assessed with the help of these models. In this study, we present the definition of mathematical modeling, advantages and disadvantages of modelling and introduce an extensive summary of published literature. We mainly focus on three modeling methodology: Markov models, compartmental models and agent-based simulation.

Kaynakça

  • 1. Denton B, Verter V. Health care O.R. OR MS Today. 2010. http://www.lionhrtpub.com/ab/wpgen.shtml. Accessed March 9, 2020.
  • 2. Türkiye Odalar ve Borsalar Birliği. Türkiye Sağlık Sektörüne Genel Bakış.; 2017. https://www.tobb.org.tr/saglik/20171229-tss-genel-bakis-tr.pdf. Accessed March 9, 2020.
  • 3. Fries BE. Bibliography of Operations Research in Health-Care Systems. Oper Res. 1976;24(5):801-814. doi:10.1287/opre.24.5.801
  • 4. Pierskalla WP, Brailer DJ. Applications of operations research in health care delivery. Handbooks Oper Res Manag Sci. 1994;6(C):469-505. doi:10.1016/S0927-0507(05)80094-5
  • 5. Brandeau, Margaret L., Sainfort, Francois, Pierskalla WP. Operations Research and Health Care: A Handbook of Methods and Applications.; 2004. doi:10.1057/jos.2009.8
  • 6. Rais A, Vianaa A. Operations research in healthcare: A survey. Int Trans Oper Res. 2011;18(1):1-31. doi:10.1111/j.1475-3995.2010.00767.x
  • 7. Fakhimi M, Probert J. Operations research within UK healthcare: A review. J Enterp Inf Manag. 2013;26(1):21-49. doi:10.1108/17410391311289532
  • 8. Caro JJ, Briggs AH, Siebert U, Kuntz KM. Modeling good research practices-overview: A report of the ISPOR-SMDM modeling good research practices task force-1. Med Decis Mak. 2012;32(5):667-677. doi:10.1177/0272989X12454577
  • 9. Eddy DM, Hollingworth W, Caro JJ, Tsevat J, McDonald KM, Wong JB. Model transparency and validation: A report of the ISPOR-SMDM modeling good research practices task force-7. Med Decis Mak. 2012;32(5):733-743. doi:10.1177/0272989X12454579
  • 10. Briggs AH, Weinstein MC, Fenwick EAL, Karnon J, Sculpher MJ, Paltiel AD. Model parameter estimation and uncertainty analysis: A report of the ISPOR-SMDM modeling good research practices task force working group-6. Med Decis Mak. 2012;32(5):722-732. doi:10.1177/0272989X12458348
  • 11. Roberts M, Russell LB, Paltiel AD, Chambers M, McEwan P, Krahn M. Conceptualizing a model: A report of the ISPOR-SMDM modeling good research practices task force-2. Med Decis Mak. 2012;32(5):678-689. doi:10.1177/0272989X12454941
  • 12. Karnon J, Stahl J, Brennan A, Caro JJ, Mar J, Möller J. Modeling using discrete event simulation: A report of the ISPOR-SMDM modeling good research practices task force-4. Med Decis Mak. 2012;32(5):701-711. doi:10.1177/0272989X12455462
  • 13. Siebert U, Alagoz O, Bayoumi AM, et al. State-transition modeling: A report of the ISPOR-SMDM modeling good research practices task force-3. Med Decis Mak. 2012;32(5):690-700. doi:10.1177/0272989X12455463
  • 14. Simpson KN, Strassburger A, Jones WJ, Dietz B, Rajagopalan R. Comparison of Markov model and discrete-event simulation techniques for HIV. Pharmacoeconomics. 2009;27(2):159-165. doi:10.2165/00019053-200927020-00006
  • 15. Meltzer MI, Damon I, Leduc JW, Donald Millar J. Modeling Potential Responses to Smallpox as a Bioterrorist Weapon. Vol 7. http://www.cdc.gov/ncidod/eid/vol7no6/. Accessed March 9, 2020.
  • 16. Myers ER, McCrory DC, Nanda K, Bastian L, Matchar DB. Mathematical model for the natural history of human papillomavirus infection and cervical carcinogenesis. Am J Epidemiol. 2000;151(12):1158-1171. doi:10.1093/oxfordjournals.aje.a010166
  • 17. Chhatwal J, Kanwal F, Roberts MS, Dunn MA. Cost-effectiveness and budget impact of hepatitis C virus treatment with sofosbuvir and ledipasvir in the United States. Ann Intern Med. 2015;162(6):397-406.
  • 18. Yaylali E, Ivy JS, Taheri J. Systems engineering methods for enhancing the value stream in public health preparedness: The role of Markov models, simulation, and optimization. Public Health Rep. 2014;129. doi:10.1177/00333549141296S419
  • 19. Sanders GD, Bayoumi AM, Sundaram V, et al. Cost-effectiveness of screening for HIV in the era of highly active antiretroviral therapy. N Engl J Med. 2005;352(6):570-585.
  • 20. Shadick NA, Liang MH, Phillips CB, Fossel K, Kuntz KM. The cost-effectiveness of vaccination against Lyme disease. Arch Intern Med. 2001;161(4):554-561. doi:10.1001/archinte.161.4.554
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  • 22. Yaesoubi R, Cohen T. Generalized Markov models of infectious disease spread: A novel framework for developing dynamic health policies. Eur J Oper Res. 2011;215(3):679-687. doi:10.1016/j.ejor.2011.07.016
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  • 79. Balçik PY, Şahin B. Cost-effectiveness analysis of pemetrexed and gemcitabine treatment for advanced nonsmall cell lung cancer in turkey. Turkish J Med Sci. 2016;46(1):152-158. doi:10.3906/sag-1408-4
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  • 82. Kretzschmar M, Wallinga J. Mathematical Models in Infectious Disease Epidemiology. In: Krämer A, Kretzschmar M, Krickeberg K, eds. Modern Infectious Disease Epidemiology. New York, NY: Springer; 2009:209-221. doi:10.1007/978-0-387-93835-6_12
Toplam 82 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Derleme makalesi
Yazarlar

Emine Yaylalı 0000-0002-6707-9521

Yayımlanma Tarihi 30 Eylül 2020
Gönderilme Tarihi 24 Temmuz 2020
Kabul Tarihi 7 Eylül 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 5 Sayı: 3

Kaynak Göster

AMA Yaylalı E. Sağlık Araştırmalarında Matematik Model Kullanımı. OTSBD. Eylül 2020;5(3):528-540. doi:10.26453/otjhs.773674

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