Hipertansiyonu Olan Geriatrik Hastalarda Dipper/Non-Dipper Paterni ile Nötrofil-Lenfosit Oranı ve Trombosit-Lenfosit Oranı arasındaki İlişki

Yıl 2025, Cilt: 10 Sayı: 1, 76 - 81

Perihan Varım , Ahmet Can Çakmak

https://doi.org/10.26453/otjhs.1619335

Öz

Amaç: Nötrofil lenfosit (NLR) ve trombosit lenfosit oranı (PLR), kötü prognozu gösteren bir inflamatuar belirteçtir. Non-dipper hipertansiyon, kardiyovasküler olaylar için daha yüksek risk ile ilişkilidir. Bu çalışmanın amacı, dipper ve non-dipper hipertansiyonu olan hastalarda NLR ve PLR arasındaki ilişkiyi araştırmaktır.
Materyal ve Metot: Çalışmaya hipertansiyonu olan 124 geriatrik hasta dahil edildi. Hastalar ambulatuvar kan basıncı ölçümüne göre non-dipper (n:62, grup 1) ve dipper (n:62, grup 2) olmak üzere iki gruba ayrıldı. Nötrofil lenfosit (NLR) ve trombosit lenfosit oranı (PLR), mutlak nötrofil sayısı ve trombosit sayısının mutlak lenfosit sayısına bölünmesiyle hesaplandı.
Bulgular: İki grup arasında cinsiyet, yaş, kronik hastalıklar e sigara içiciliği açısından anlamlı fark yoktu (p>0,005). Kronik hastalıklar ve sigara kullanımı açısından da anlamlı fark yoktu. NLR grup 1'de 1,96±0,66 iken grup 2'de 1,67±0,68 idi (p:0,005). PLR grup 1'de 146±42,2 iken grup 2'de 115±34,2 idi (p:0,001).
Sonuç: Bulgularımız non-dipper HT'li geriatrik hastaların, dipper HT'li hastalara göre anlamlı derecede daha yüksek NLR ve PLR'ye sahip olduğunu göstermektedir. Bu, non-dipper HT'nin daha yüksek inflamasyonla ilişkili olduğunu ve bunun da daha yüksek kardiyovasküler riske katkıda bulunabileceğini göstermektedir.

Anahtar Kelimeler

Dipper, geriatrik hastalar, NLR, non dipper, PLR

Relationship Between Dipper/Non-Dipper Pattern and Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Geriatric Patients with Hypertension

Öz

Objective: Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) are inflammatory markers associated with poor prognoses. Non-dipper hypertension (HT) is linked to a higher risk for cardiovascular events. This study aims to investigate the association between NLR and PLR in geriatric patients with dipper and non-dipper HT.
Materials and Methods: A total of 124 geriatric patients with HT were included in the study. Based on ambulatory blood pressure monitoring, patients were categorized into two groups: non-dippers (n=62, Group 1) and dippers (n=62, Group 2). NLR and PLR were calculated by dividing the absolute neutrophil and platelet counts, respectively, by the absolute lymphocyte count.
Results: There were no significant differences in sex, age, chronic conditions and smoking between the two groups (p>0.005). The NLR was 1.96±0.66 in group 1 and 1.67±0.68 in group 2 (p:0.005). The PLR was 146±42.2 in group 1 and 115±34.2 in group 2 (p:0.001). The NLR and PLR were significantly higher in non-dippers compared to dippers (p<0.005).
Conclusion: Our findings demonstrate that geriatric patients with non-dipper HT have significantly higher NLR and PLR compared to those with dipper HT. This suggests that non-dipper HT is associated with greater inflammation, which may contribute to its higher cardiovascular risk.

Anahtar Kelimeler

Dipper, geriatric patients, NLR, non dipper, PLR

Kaynakça

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