2-aminobenzotiyazolün karışık ligandlı metal kompleksleri ve biyolojik özellikleri hakkında literatür çalışması

Yıl 2018, Cilt: 24 Sayı: 7, 1360 - 1369, 28.12.2018

Halil İlkimen

Öz

2-Aminobenzotiyazol ile bazı organik bileşiklerin
[β-pikolin, γ-pikolin, isokinolin, asetilaseton, o-hidroksiasetofenon,
1,2-etilendiamin, piperazin, N,
N'-bis(4-antipirilmetil)piperazin,
N,N'-tetra(4-antipirilmetil)-1,2-diaminoetan, N,N'-bis(4-antipirilmetil)
piperazin, N, N'-tetra(4-antipirilmetil)-1,2-diaminoetan, ftalamid,
malonamid, benzilaseton, tetrametilen sulfoksit, katekol, p-klorofenoksiasetik
asit, 7-oksobisiklo[2.2.1]
heptan-2,3-dikarboksilik asit, 2,2’-bipridin, 1.10-fenantrolin, propanoik asit, fenoksiasetik, 2-imino-3-allilbenzotiyazol,
sakarin, trifenilfosfin, trifloroasetik asit, adipik asit,
1,4-benzendikarboksilik asit, süksinik asit, formik
asit, pikrik asit, amino asit, p-formilfenoksiasetik asit ve
2,6-piridindikarboksilik asit] karışık ligandlı metal komplekslerinin (M = Mn,
Fe, Co, Ni, Cu, Zn, Ag, Au, Ru, Os, Ir, Pd, Rh, U, Eu ve Tb) yapıları ve
biyolojik özelliklerini anlatan çalışmalar literatürde gözlenmiştir. Bu
bileşiklerde 2-aminobenzotiyazol metale tiyazol halkasının N ve/veya S ve/veya
animo grubundan bağlanmakta ya da tamamlayıcı iyon şeklinde yapıda yer
almaktadır. Bu komplekslerinin antibakteriyel, antikanser,
antifungal, anti-inflamatuar, antitümör ve karbonik anhidraz inhibisyonu gibi biyolojik özellikleri bilinmektedir.

Anahtar Kelimeler

2-Aminobenzotiyazol, Karışık ligand, Metal kompleksleri, Biyolojik özellikler

A review on biological properties and mixed ligand metal complexes of 2-aminobenzothiazole

Öz

The
studies about the structures and biological properties of the mixed ligand
metal complexes (Mn+, M = Mn, Fe, Co, Ni, Cu, Zn, Ag, Au, Ru, Os, Ir, Pd, Rh,
U, Eu, and Tb) of the 2- aminobenzothiazole and some organic compounds
(β-picoline, γ-picoline isopicoline, acetylaceton, o-hydroxyacetophenone, 1,2-ethylenediamine, piperazine, N,N'-bis(4-antipyrylmethyl) piperazine,
N,N'-tetra(4-antipyrylmethyl)-1,2-diaminoethane, phtalamide, malonimide,
benzylacetone, tetramethylenesulphoxide, catechol, p-chlorophenoxyacetic acid, 7-oxobicyclo[2.2.1]-heptan-2,3-dicarboxylic acid, 2,2’-bipyridine, 1,10-phenanthroline, propionic acid, phenoxyacetic acid,
2-amino-3-allylbenzothiazole, saccharine, triphenylphosphine, trichloroacetic
acid, adipic acid, 1,4-benzenedicarboxylic acid,  succinic acid, formic acid, picric acid,
amino acid, p-formylphenoxyacetik acid and 2,6-pyridinedicarboxylic acid) have been observed in the literature. In these
compounds, 2-aminobenzothiazole connected to the metal from N or S or amine
group of thiazole ring or take part in the structure as the complementary form.
Some biological properties such as antimicrobial, anticancer, antifungal,
anti-inflammatory, antitumor and inhibition of carbonic anhydrase of these
complexes are well-known.

Anahtar Kelimeler

2-Aminobenzothiazole, Mixed ligand, Metal complexes, Biological properties

Kaynakça

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