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Diklofenak’ın bozunması, dönüşüm ürünleri ve çevresel akıbeti üzerine inceleme

Yıl 2022, Cilt: 28 Sayı: 6, 937 - 952, 30.11.2022

Öz

Diklofenak, insan ve veterinerlik amaçlı yaygın kullanılan ilaçlardan biri olmuştur. Diklofenak’ın çevre ve organizmalar üzerindeki olumsuz etkilerinin ortaya çıkmasıyla, araştırma çalışmaları atıksudan uzaklaştırılmasına yönelmiştir. Atıksu ya da yüzeysel suda mikrogram düzeyindeki derişimlerine rağmen, endokrin sistemini bozabilir, bu da üst düzey organizmaların metabolizmasında dolayısıyla ekosistemde sorunlara yol açabilir. Bu nedenle diklofenakın tüketiminden başlayarak etkin diklofenak arıtımına, deşarj standartlarının belirlenmesine ve su yaşamının üst düzeyde korunmasına kadar uzanan bir yelpazede diklofenak kontrolü için acil önlemler alınmalıdır. Diklofenak ile ilgili diğer bir problem ise, fotoliz ve biyolojik reaksiyonları ile oluşan bozunma ürünlerinin atıksu arıtma tesislerinin çıkışında bulunmasıdır. Bu dönüşüm ürünleri organizmalar için daha fazla tehdit oluşturmaktadır. Dolayısıyla, bu derleme makalesi diklofenakın çevre üzerindeki olumsuz etkilerini, birincil diklofenak kaynaklarını, hayvanlar üzerindeki endokrin bozucu etkilerini, insan vücudundaki metabolizmasını, arıtma yaklaşımlarını, biyolojik ve kimyasal bozunma metabolitlerinin türünü veya dönüşüm ürünlerini vurgulamayı amaçlamaktadır.

Kaynakça

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A review on diclofenac degradation, transformation products and their fate in the environment

Yıl 2022, Cilt: 28 Sayı: 6, 937 - 952, 30.11.2022

Öz

Diclofenac has been one of the widely consumed pharmaceuticals for human and veterinary purposes. The research studies are devoted to investigating its removal from wastewater since its adverse effect on the environment and the organisms have been revealed. Despite its microgram level concentrations in the wastewater or water bodies, it could disrupt the endocrine system, which leads to problems in the metabolism of the higher-level organisms and, thereby, the ecosystem. Therefore, urgent measures should be taken to control diclofenac starting from its consumption and extending to the efficient diclofenac treatment, determination of discharge standards, or the high-level protection of aquatic life. Another problem with diclofenac is the degradation end-products that form through photolysis, or biological reactions remain in the wastewater treatment plants' effluent. These transformation products create further threats for the organisms. This review paper aims to emphasize the adverse effects of diclofenac on the environment, the primary diclofenac sources, its endocrine disrupting effects on the animals, metabolism in the human body, treatment approaches, type of biological and chemical degradation metabolites, or transformation products.

Kaynakça

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  • [96] Poirier-Larabie S, Segura PA, Gagnon C. "Degradation of the pharmaceuticals diclofenac and sulfamethoxazole and their transformation products under controlled environmental conditions". Science of the Total Environment, 557-558(15), 257-267, 2016.
  • [97] Barbieri M, Carrera J, Ayora C, Sanchez-Vila X, Licha T, Nödler K, Osorio V, Pérez S, Köck-Schulmeyer M, López de Alda M, Barceló D. "Formation of diclofenac and sulfamethoxazole reversible transformation products in aquifer material under denitrifying conditions: Batch experiments". Science of the Total Environment, 426(11), 256-263, 2012.
  • [98] Lahti M, Oikari A. "Microbial transformation of pharmaceuticals naproxen, bisoprolol, and diclofenac in aerobic and anaerobic environments". Archives of Environment Contamination and Toxicology, 61(2), 202-210, 2011.
  • [99] Jayasinghe C, Imtiaj A, Lee GW, Im KH, Hur H, Lee MW, Yang HS, Lee TS. "Degradation of three aromatic dyes by white rot fungi and the production of ligninolytic enzymes". Mycobiology, 36(2), 114-120, 2008.
  • [100]McMullan G, Meehan C, Conneely A, Kirby N, Robinson T, Nigam P, Banat I, Marchant R, Smyth W. "Microbial decolourisation and degradation of textile dyes". Applied Microbiology and Biotechnology, 56(1), 81-87, 2001.
  • [101] Swamy J, Ramsay JA. "The evaluation of white rot fungi in the decoloration of textile dyes". Enzyme and Microbial Technology, 24(3), 130-137, 1999.
  • [102] Bhatt M, Cajthaml T, Šašek V. "Mycoremediation of PAHcontaminated soil". Folia Microbiologica, 47(3), 255-258, 2002.
  • [103] Field JA, de Jong E, Feijoo Costa G, de Bont JA. "Biodegradation of polycyclic aromatic hydrocarbons by new isolates of white rot fungi". Applied and Environmental Microbiology, 58(7), 2219-2226, 1992.
  • [104] Zhang H, Zhang S, He F, Qin X, Zhang X, Yang Y. "Characterization of a manganese peroxidase from whiterot fungus Trametes sp.48424 with strong ability of degrading different types of dyes and polycyclic aromatic hydrocarbons". Journal of Hazardous Materials, 320(20), 265-277, 2016.
  • [105] Shreve MJ, Brockman A, Hartleb M, Prebihalo S, Dorman FL, Brennan RA. "The white-rot fungus Trametes versicolor reduces the estrogenic activity of a mixture of emerging contaminants in wastewater treatment plant effluent". International Biodeterioration & Biodegradation, 109(4), 132-140, 2016.
  • [106] Yang S, Hai FI, Nghiem LD, Nguyen LN, Roddick F, Price WE. "Removal of bisphenol A and diclofenac by a novel fungal membrane bioreactor operated under non-sterile conditions". International Biodeterioration & Biodegradation, 85(10), 483-490, 2013.
  • [107] Asif MB, Hai FI, Singh L, Price WE, Nghiem LD. "Degradation of Pharmaceuticals and Personal Care Products by White-Rot Fungi-a Critical Review". Current Pollution Reports, 3(2), 88-103, 2017.
  • [108] Marco-Urrea E, Pérez-Trujillo M, Cruz-Morató C, Caminal G, Vicent T. "White-rot fungus-mediated degradation of the analgesic ketoprofen and identification of intermediates by HPLC-DAD–MS and NMR". Chemosphere, 78(4), 474-481, 2010.
  • [109] Marco-Urrea E, Pérez-Trujillo M, Vicent T, Caminal G. "Ability of white-rot fungi to remove selected pharmaceuticals and identification of degradation products of ibuprofen by Trametes versicolor". Chemosphere, 74(6), 765-772, 2009.
  • [110] Rodarte-Morales AI, Feijoo G, Moreira MT, Lema JM. "Degradation of selected pharmaceutical and personal care products (PPCPs) by white-rot fungi". World Journal of Microbiology and Biotechnology, 27(8), 1839-1846, 2011.
  • [111] Schmidt S, Hoffmann H, Garbe LA, Schneider RJ. "Liquid chromatography-tandem mass spectrometry detection of diclofenac and related compounds in water samples". Journal of Chromatography A, 1538(8), 112-116, 2018.
  • [112] Suarez S, Reif R, Lema JM, Omil F. "Mass balance of pharmaceutical and personal care products in a pilotscale single-sludge system: influence of T, SRT and recirculation ratio". Chemosphere, 89(2), 164-171, 2012.
  • [113] Bouju H, Nastold P, Beck B, Hollender J, Corvini PFX, Wintgens T. "Elucidation of biotransformation of diclofenac and 4′hydroxydiclofenac during biological wastewater treatment". Journal of Hazardous Materials, 301(1), 443-452, 2016.
  • [114] Zhou H, Liu J, Chen X, Ying Z, Zhang Z, Wang M. "Fate of pharmaceutically active compounds in sewage sludge during anaerobic digestions integrated with enzymes and physicochemical treatments". Waste Management, 78, 911-916, 2018.
  • [115] Kummerová M, Zezulka Š, Babula P, Tříska J. "Possible ecological risk of two pharmaceuticals diclofenac and paracetamol demonstrated on a model plant Lemna minor". Journal of Hazardous Materials, 302(2), 351-361, 2016.
Toplam 115 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Mühendislik
Bölüm İnşaat Müh. / Çevre Müh. / Jeoloji Müh.
Yazarlar

Serenay Ceren Tüzün Bu kişi benim

Ilgi Karapınar Bu kişi benim

Yayımlanma Tarihi 30 Kasım 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 28 Sayı: 6

Kaynak Göster

APA Tüzün, S. C., & Karapınar, I. (2022). A review on diclofenac degradation, transformation products and their fate in the environment. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi, 28(6), 937-952.
AMA Tüzün SC, Karapınar I. A review on diclofenac degradation, transformation products and their fate in the environment. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi. Kasım 2022;28(6):937-952.
Chicago Tüzün, Serenay Ceren, ve Ilgi Karapınar. “A Review on Diclofenac Degradation, Transformation Products and Their Fate in the Environment”. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi 28, sy. 6 (Kasım 2022): 937-52.
EndNote Tüzün SC, Karapınar I (01 Kasım 2022) A review on diclofenac degradation, transformation products and their fate in the environment. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi 28 6 937–952.
IEEE S. C. Tüzün ve I. Karapınar, “A review on diclofenac degradation, transformation products and their fate in the environment”, Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi, c. 28, sy. 6, ss. 937–952, 2022.
ISNAD Tüzün, Serenay Ceren - Karapınar, Ilgi. “A Review on Diclofenac Degradation, Transformation Products and Their Fate in the Environment”. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi 28/6 (Kasım 2022), 937-952.
JAMA Tüzün SC, Karapınar I. A review on diclofenac degradation, transformation products and their fate in the environment. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi. 2022;28:937–952.
MLA Tüzün, Serenay Ceren ve Ilgi Karapınar. “A Review on Diclofenac Degradation, Transformation Products and Their Fate in the Environment”. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi, c. 28, sy. 6, 2022, ss. 937-52.
Vancouver Tüzün SC, Karapınar I. A review on diclofenac degradation, transformation products and their fate in the environment. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi. 2022;28(6):937-52.





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