Evaluation of clinical, laboratory and prognosis of patients in an influenza epidemic

Abstract

Objective: Influenza is an infectious respiratory disease that causes widespread epidemics and pandemics in the community. It is usually self-limiting but may cause significant morbidity and mortality due to complications. We aimed at evaluating the clinical, laboratory and prognosis of adult patients hospitalised with a pre-diagnosis of seasonal influenza.
Materials and methods: It is a descriptive study based on the data from 50 patients hospitalised with a preliminary diagnosis of seasonal influenza between 1 December 2015 and 31 January 2016.
Results: The average age of the patients was 55.44±17.17 years (20-89) and 64% of them were women. Of the cases, 36% were H1N1 positive, 30% were H3N2 positive and 34% had negative PCR results. The time from the onset of symptoms to hospital admission was 3.72±2.51 days (1-11). Comorbidities were present in 38 (76%) patients. Four patients had mortality.
Conclusion: Influenza can be self-limited according to the characteristics of the host, as well as cause mortality. In this study, it was found to cause severe illness and death in a healthy young adult. Therefore, it is important to avoid contact with infected patients, hand washing and vaccination to reduce influenza and its complications. In addition, if our preliminary diagnosis of influenza continues, further evaluations should be made even if the PCR is negative.

Keywords

• Influenza
• epidemic
• mortality
• H1N1
• vaccine

Bir influenza epidemisinde hastaların klinik, laboratuvar ve prognozlarının değerlendirilmesi

Öz

Amaç: İnfluenza, toplumda yaygın olarak görülen epidemi ve pandemilere yol açan bulaşıcı bir solunum yolu hastalığıdır. Genellikle kendi kendini sınırlayabilirken komplikasyonlar nedeniyle önemli morbidite ve mortaliteye neden olabilir. Mevsimsel grip ön tanısıyla yatırılarak takip edilen erişkin hastaların klinik, laboratuvar ve prognozlarının değerlendirilmesi amaçlandı.
Gereç ve yöntem: 1 Aralık 2015-31 Ocak 2016 tarihleri arasında mevsimsel influenza ön tanısı ile yatırılan 50 hastanın bilgilerine dayanan tanımlayıcı bir araştırmadır.
Bulgular: Hastaların ortalama yaşı 55,44±17,17 (20-89) ve %64’ü kadın cinsiyette idi. Olguların %36’sı H1N1 pozitif, %30’u H3N2 pozitif ve %34’ünün PCR sonucu ise negatif idi. Semptomların başlamasından itibaren hastaneye başvurana dek geçen süre 3,72±2,51 gündü (1-11). 38 (%76) hastanın komorbiditesi bulunmaktaydı. Dört hastada mortalite ile sonuçlandı.
Sonuç: İnfluenza, konağın özelliğine göre kendi kendi sınırlayabildiği gibi mortaliteye de neden olmaktadır. Bu çalışmada sağlıklı, genç bir erişkinde şiddetli hastalık ve ölüme neden olduğu görüldü. Bu nedenle influenzayı ve komplikasyonlarını azaltmak için enfekte hastalar ile temastan kaçınmak, el yıkama ve aşılama önemlidir. Ayrıca influenza ön tanımız devam ediyorsa PCR negatif olsa bile ileri değerlendirmeler yapılmalıdır.

Anahtar Kelimeler

• İnfluenza
• epidemi
• mortalite
• H1N1
• aşı

Kaynakça

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