Relationship between cerebrovascular diseases and human leukocyte antigen subgroups

Abstract

Abstract Purpose: Ischemic stroke is classified as large artery atherosclerosis, small vessel occlusion (lacunar infarcts), ischemic stroke due to other identified causes, and cryptogenic. The human leukocyte antigen (HLA) complex is a group of genes on chromosome six in humans responsible for encoding cell-surface proteins that regulate the immune system. In this study, HLA’s roles in the pathophysiology of ischemic stroke, especially the lacunar subgroup, are investigated, and their potential mechanisms are presented. Materials and methods: This study consisted of 49 patients with ischemic stroke and 50 healthy participants. HLA-A, HLA-B, HLA-C, HLA-DQB, and HLA-DRB subgroup genomes were assessed. Results: A statistically significant difference in the presence of HLA-A, HLA-B, HLA-C, HLA-DQB, and HLADRB subgroups was found between the control and patient groups. The presence of HLA-A*02, HLA-A*30, HLA-B*08, HLA-B*15, and HLA-DQB*06 genomes was higher in the patient group than in the control group (p≤0.05). Nevertheless, HLA-DQB*03 and HLA-DRB*11 genomes were found more in the control group than the patient group (p≤0.05) Conclusion: The results of this study pioneered in scrutinizing HLA alleles in small vascular disease (SVD). HLA-A*01, HLA-A*30, HLA-B*08, HLA-B*15, HLA-DQB*06, HLA-DQB*03 and HLA-DRB*11 are associated with HLA alleles of stroke patients with small vessel occlusion. We attempted to provide objective evidence for whether HLA genomes could act as a discriminative factor between SVD patients and control groups, which might hold considerable promise for future therapies.

Keywords

• Stroke
• major histocompatibility complex
• genome
• small vessel disease
• ischemia

Serebrovasküler hastalıklar ile insan lökosit antijen alt grupları arasındaki ilişki

Öz

Amaç: İskemik inme, büyük arter aterosklerozu, küçük damar tıkanıklığı (laküner enfarktlar), diğer tanımlanmış nedenlere bağlı iskemik inme ve kriptojenik olarak sınıflandırılır. İnsan lökosit antijeni (HLA) kompleksi insanlarda bağışıklık sistemini düzenleyen hücre yüzeyi proteinlerini kodlamaktan sorumlu, altıncı kromozom üzerinde yer alan bir grup gendir. Bu araştırmada, HLA'nın iskemik inme patofizyolojisindeki özellikle laküner alt gruptaki rollerinin araştırılması ve olası mekanizmaların aydınlatması amaçlanmıştır. Gereç ve yöntem: Bu çalışma iskemik inmeli 49 hasta ve 50 sağlıklı katılımcıdan oluşmaktadır. HLA-A, HLA-B, HLA-C, HLA-DQB ve HLA-DRB alt grup genomları değerlendirilmiştir. Bulgular: Kontrol ve hasta gruplarında HLA-A, HLA-B, HLA-C, HLA-DQB ve HLA-DRB alt gruplarının varlığı arasında istatistiksel olarak anlamlı fark bulunmuştur. HLA-A*02, HLA-A*30, HLA-B*08, HLA-B*15 ve HLADQB* 06 genomları hasta grubunda daha fazla bulunmuştur ve istatistiksel olarak anlamlı fark vardır (p≤0.05). Bununla birlikte HLA-DQB*03 ve HLA-DRB*11 genomları kontrol grubunda daha fazla bulunmuştur (p≤0.05). Sonuç: Bu araştırma, küçük damar hastalığında (KDH) HLA alellerini incelemede öncüdür. HLA-A*01, HLA-A*30, HLA-B*08, HLA-B*15, HLA-DQB*06, HLA-DQB*03, HLA-DRB*11, inme hastalarının HLA alelleri ile ilişkilidir. Küçük damar tıkanıklığı HLA genomlarının, KDH hastaları ve kontrol grupları arasında, gelecekteki tedaviler için umut vaat edebilecek, ayırt edici bir faktör olarak hareket edip edemeyeceğine dair nesnel kanıtlar sağlamaya çalıştık.

Anahtar Kelimeler

• Strok
• major doku uygunluk kompleksi
• genom
• küçük damar hastalığı
• iskemi

Kaynakça

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