Relationship between CONUT score and mortality in patients with pulmonary arterial hypertension
Öz
Purpose: Data about the association of malnutrition with prognosis in pulmonary arterial hypertension (PAH) is limited. This study aims to evaluate the relationship of Controlling Nutritional Status (CONUT) score with long-term mortality in PAH.
Materials and methods: All consecutive patients newly diagnosed with PAH between 2013 and 2020 were evaluated. CONUT score at diagnosis was calculated through total lymphocyte, albumin and total cholesterol levels. Primary outcome was long-term all-cause mortality. Patients were followed up for 62 (31.3-91.5) months.
Results: 92 patients (mean age=43.9±15.7 years, 65.2% women) were included. 37% of the patients had any degree of malnutrition according to CONUT score (≥2). Patients without malnutrition were significantly more in the low-risk categories of risk stratification tools (44.8% vs 17.6% according to ESC/ERS guideline, p=0.03; 70.7% vs 35.3% and 70.7% vs 32.4% according to REVEAL 2.0 and REVEAL Lite 2, p<0.01 for both). In multivariate analysis, CONUT score predicted all-cause mortality (HR:1.51, 95% CI:1.01-1.52, p=0.03) independently after adjustment with ESC/ERS guideline risk score.
Conclusion: CONUT score is independently associated with worse outcome in PAH patients and may indicate severe disease in this patient group.
Anahtar Kelimeler
Pulmonary arterial hypertension, malnutrition, controlling nutritional status score, mortality
Kaynakça
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