Primer meme tümörleri ile karaciğer metastazları arasında ER, PR, HER2 ve Ki-67 ekspresyon uyumunun değerlendirilmesi: 57 olgunun retrospektif analizi

Öz

Amaç: Bu çalışma, primer meme tümörleri ile karaciğer metastazları arasındaki östrojen reseptörü (ER), progesteron reseptörü (PR), insan epidermal büyüme faktörü reseptörü 2 (HER2) ve Ki-67 ekspresyonundaki değişiklikleri değerlendirmeyi amaçlamaktadır. Gereç ve yöntem: Meme kanseri karaciğer metastazı bulunan toplam 57 hasta çalışmaya dahil edilmiştir. Primer ve metastatik tümörlerde ER, PR, HER2 ve Ki-67 ekspresyonunu değerlendirmek için immünohistokimyasal boyama uygulanmıştır. Gerekli durumlarda HER2 durumu, silver in situ hibridizasyon (SISH) yöntemi ile doğrulanmıştır. Biyomarker ekspresyonundaki değişiklikleri değerlendirmek amacıyla istatistiksel analizler yapılmıştır. Bulgular: Primer ve metastatik biyopsiler arasındaki biyobelirteç ekspresyonları karşılaştırıldığında, 5 olguda ER durumunda değişiklik (1 olgu negatiften pozitife, 4 olgu pozitiften negatife), 22 olguda PR durumunda değişiklik (4 olgu negatiften pozitife, 18 olgu pozitiften negatife), 5 olguda HER2 durumunda değişiklik (2 olgu negatiften pozitife, 3 olgu pozitiften negatife) ve 13 olguda Ki-67 durumunda değişiklik (6 olgu düşükten yükseğe, 7 olgu yüksekten düşüğe) saptanmıştır. ER, PR, HER2 ve Ki-67 için diskordans oranları sırasıyla %8,8, %38,6, %8,8 ve %28,9 olarak hesaplanmıştır. Sonuç: Bulgularımız, primer ve metastatik meme kanseri lezyonları arasında biyobelirteç ekspresyonunda değişiklikler olabileceğini doğrulamaktadır. Reseptör durumunun tedavi kararlarındaki kritik rolü göz önünde bulundurulduğunda, metastatik lezyonlardan yeni biyopsi yapılması, kişiye özel tedavi planlamasında önemli bir yol gösterici olabilir.

Anahtar Kelimeler

• Meme kanseri
• östrojen reseptörü
• progesteron reseptörü
• HER2
• diskordans

Evaluation of the concordance of ER, PR, HER2, and Ki-67 expression levels between primary breast tumors and their liver metastases: a retrospective analysis of 57 cases

Öz

Purpose: This study aims to evaluate the changes in estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67 expression between primary breast tumors and their liver metastases. Materials and methods: A total of 57 patients with breast cancer liver metastases were included. Immunohistochemical staining was performed to assess ER, PR, HER2, and Ki-67 expression in both primary and metastatic tumors. HER2 status was confirmed by silver in situ hybridization (SISH) when necessary. Statistical analyses were conducted to evaluate changes in biomarker expression. Results: Comparison of biomarker expression between primary and metastatic biopsies revealed changes in ER status in 5 cases (1 from negative to positive, 4 from positive to negative); PR status in 22 cases (4 from negative to positive, 18 from positive to negative); HER2 status in 5 cases (2 from negative to positive, 3 from positive to negative); and Ki-67 status in 13 cases (6 from low to high, 7 from high to low). The discordance rates for ER, PR, HER2, and Ki-67 were calculated as 8.8%, 38.6%, 8.8%, and 28.9%, respectively. Conclusion: Our findings confirm that biomarker expression may change between primary and metastatic breast cancer lesions. Given the crucial role of receptor status in treatment decisions, re-biopsy of metastatic lesions is essential to guide personalized therapy.

Anahtar Kelimeler

• Breast cancer
• estrogen receptor
• progesterone receptor
• HER2
• discordance

Kaynakça

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