Does the neutrophil-to-lymphocyte ratio affect survival in multiple myeloma?

Yıl 2026, Cilt: 19 Sayı: 1, 185 - 192, 16.01.2026

Seher Yılmaz , Gulsum Akgun Cagliyan , Eda Nilüfer Coşkun , İsmail Can Kendir , Kayıhan Kara , Sibel Hacıoğlu

Öz

Purpose: Neutrophil-to-Lymphocyte Ratio (NLR) is an inflammatory marker that has shown prognostic significance in malignancies. This study aimed to investigate the relationship between NLR and overall survival (OS) as well as other prognostic indicators in patients diagnosed with Multiple Myeloma (MM).
Materials and methods: A total of 196 patients diagnosed with MM were included in the study. Demographic characteristics, laboratory values, clinical status, and the presence of autologous stem cell transplantation (ASCT) were retrospectively reviewed. The impact on overall survival and prognosis was evaluated.
Results: In the patient group with an NLR>1.8, the mean age was higher and the median OS was shorter. There was a statistically significant relationship between NLR and the presence of renal dysfunction, as well as being over 65 years of age (p=0.012, p=0.035). The presence of renal dysfunction, Stage 3 disease, age >65 years, and the absence of ASCT were associated with decreased overall survival (p=0.001, p=0.001, p<0.001, p<0.001, respectively). There was no direct correlation between NLR and OS.
Conclusion: In the present study, no correlation was found between OS and NLR. This may be due to the presence of other factors affecting the NLR, such as oxidative stress, infection, and inflammation. The existence of common parameters influencing both NLR and OS suggests that NLR is a useful marker in the assessment of survival and prognosis.

Anahtar Kelimeler

Neutrophil-to-Lymphocyte Ratio (NLR) , multiple myeloma , survival , prognosis

Multipl myelomda nötrofil lenfosit oranı sağkalımı etkiler mi?

Öz

Amaç: Nötrofil Lenfosit Oranı (NLR), malignitelerde prognostik önemi gösterilen bir inflamasyon belirtecidir. Bu çalışmada MM tanılı hastalarda NLR oranının sağkalım ve diğer prognostik belirteçlerle ilişkisini incelemeyi amaçladık.
Gereç ve yöntem: Çalışmaya MM tanılı 196 hasta dahil edildi. Hastaların demografik özellikleri, laboratuvar değerleri, klinik durumları ve OKİT varlığı verileri geriye dönük olarak tarandı. Sağkalım ve prognoz üzerine etkileri değerlendirildi.
Bulgular: NLR>1.8 olan hasta grubunda yaş ortalaması daha yüksek, medyan OS daha kısa olarak bulundu. NLR ve renal disfonksiyon varlığı, >65 yaş arasında istatistiksel açıdan anlamlı bir ilişki vardı. (p=0,012, p=0,035) Renal disfonksiyon varlığı, Evre 3 hastalık, >65 yaş olma ve OKİT yapılmamış olma azalmış sağkalım ile ilişkiliydi. (p=0,001, p=0,001, p<0,001, p<0,001) NLR ve OS arasında direk olarak anlamlı bir ilişki saptanmadı.
Sonuç: Çalışmamızda OS ve NLR arasında ilişki saptanmaması NLR değerini etkileyen oksidatif stres, enfeksiyon, inflamasyon vb. gibi diğer durumların varlığına bağlı olabilir. NLR ve OS’yi etkileyen ortak parametrelerin olması NLR değerinin sağkalım ve prognozu değerlendirmede yardımcı bir belirteç olduğunu göstermektedir.

Anahtar Kelimeler

Nötrofil-Lenfosit oranı (NLR) , multipl myelom , sağkalım (OS) , prognoz

Kaynakça

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