Prediction of pathological complete response after neoadjuvant treatment in triple negative breast cancer: a single center experience

Öz

Purpose: To identify clinicopathological factors associated with pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in patients with triple-negative breast cancer (TNBC).
Matherials and methods: A retrospective study of 51 women with stage I–III TNBC who received NAC between January 2019 and December 2024 at Antalya Training and Research Hospital. Binary logistic regression was used to determine independent predictors of pCR.
Results: The median age was 49 years (range: 28-79), and 28 patients (54.9%) achieved pCR. Patients aged ≥60 were significantly less likely to achieve pCR (OR: 0.22; 95% CI: 0.05-0.98; p=0.048*). No significant associations were found for carboplatin or pembrolizumab use.
Conclusion: This real-world cohort confirms that pCR rates are consistent with literature. Advanced age was a significant negative predictor, emphasizing the importance of personalized approaches in elderly patients.

Anahtar Kelimeler

• Triple-negative breast cancer
• neoadjuvant treatment
• pathological complete response

Üçlü negatif meme kanserinde neoadjuvan tedavi sonrası patolojik tam yanıtın öngörülmesi: tek merkez deneyimi

Öz

Amaç: Üçlü negatif meme kanseri (TNBC) hastalarında neoadjuvan kemoterapi (NAK) sonrası patolojik tam yanıt (pTY) ile ilişkili klinikopatolojik faktörleri belirlemektir.
Gereç ve yöntem: Ocak 2019 - Aralık 2024 tarihleri arasında Antalya Eğitim ve Araştırma Hastanesi'nde NAK almış evre I–III TNBC tanılı 51 kadın hastanın verileri retrospektif olarak incelendi. pTY'yi öngören bağımsız değişkenleri belirlemek amacıyla ikili lojistik regresyon analizi yapıldı.
Bulgular: Ortanca yaş 49 (28-79) idi ve 28 hastada (%54,9) pTY elde edildi. Yaş ≥60 olan hastalarda pTY elde etme olasılığı anlamlı şekilde düşüktü (OR: 0,22; %95 GA: 0,05-0,98; p=0,048*). Karboplatin ve pembrolizumab kullanımı ile pTY arasında istatistiksel olarak anlamlı ilişki bulunmadı.
Sonuç: Gerçek yaşam verilerine dayanan bu çalışmada, pTY oranı literatürle uyumluydu. Yaşlı hastalarda pTY oranının düşük olması, kişiselleştirilmiş tedavi yaklaşımlarının gerekliliğini vurgulamaktadır.

Anahtar Kelimeler

• Üçlü negatif meme kanseri
• neoadjuvan tedavi
• patolojik tam yanıt

Kaynakça

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