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A rare neurological manifestation of seizure in a case of anaphylaxis following a hornet sting: case report & literature review

Cilt: 19 Sayı: 2 13 Nisan 2026
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A rare neurological manifestation of seizure in a case of anaphylaxis following a hornet sting: case report & literature review

Öz

Anaphylaxis is a severe, life-threatening allergic reaction that can present with a variety of systemic manifestations. Neurological symptoms such as seizures or seizure-like activity are uncommon in anaphylaxis. We present the case of a healthy young male with no history of seizures who experienced anaphylaxis following a hornet sting, manifested by urticarial rashes, facial flushing, and generalized pruritus. Interestingly, he developed seizure-like activity, characterized by focal jerky movement of the left upper limb with impaired consciousness as reported by eyewitnesses. This case highlights the atypical presentation of neurological manifestations of anaphylaxis, discusses its potential pathophysiological mechanisms, and reflecting individualized management approach in relation to established guidelines.

Anahtar Kelimeler

Destekleyen Kurum

University of Science Malaysia

Proje Numarası

1

Etik Beyan

Written informed consent was obtained from the patient for the publication of this case. Ethical approval was not required for this single-patient case report as per institutional policy.

Teşekkür

Thank you.

Kaynakça

  1. Simons FE, Ardusso LR, Bilò MB, et al. World Allergy Organization anaphylaxis guidelines: summary. J Allergy Clin Immunol. 2011;127(3):587-593e22. doi:10.1016/j.jaci.2011.01.038
  2. Lieberman P, Nicklas RA, Randolph C, et al. Anaphylaxis--a practice parameter update 2015. Ann Allergy Asthma Immunol. 2015;115(5):341-384. doi:10.1016/j.anai.2015.07.019
  3. Pumphrey RS. Lessons for management of anaphylaxis from a study of fatal reactions. Clin Exp Allergy. 2000;30(8):1144-1150. doi:10.1046/j.1365-2222.2000.00864.x
  4. Worm M, Francuzik W, Renaudin JM, et al. Factors increasing the risk for a severe reaction in anaphylaxis: An analysis of data from The European Anaphylaxis Registry. Allergy. 2018;73(6):1322-1330. doi:10.1111/all.13380
  5. Golden DB. Insect sting anaphylaxis. Immunol Allergy Clin North Am. 2007;27(2):261-vii. doi:10.1016/j.iac.2007.03.008
  6. Turner PJ, Campbell DE, Boyle RJ, Levin ME. Primary Prevention of Food Allergy: Translating Evidence from Clinical Trials to Population-Based Recommendations. J Allergy Clin Immunol Pract. 2018;6(2):367-375. doi:10.1016/j.jaip.2017.12.015
  7. Kemp SF, Lockey RF, Simons FE; World Allergy Organization ad hoc Committee on Epinephrine in Anaphylaxis. Epinephrine: the drug of choice for anaphylaxis. A statement of the World Allergy Organization. Allergy. 2008;63(8):1061-1070. doi:10.1111/j.1398-9995.2008.01733.x
  8. Schwartz LB. Diagnostic value of tryptase in anaphylaxis and mastocytosis. Immunol Allergy Clin North Am. 2006;26(3):451-463. doi:10.1016/j.iac.2006.05.010

Ayrıntılar

Birincil Dil

İngilizce

Konular

Acil Tıp

Bölüm

Olgu Sunumu

Yayımlanma Tarihi

13 Nisan 2026

Gönderilme Tarihi

10 Temmuz 2025

Kabul Tarihi

2 Aralık 2025

Yayımlandığı Sayı

Yıl 2026 Cilt: 19 Sayı: 2

Kaynak Göster

APA
Hazwan, A. E., & Fauzi, M. H. (2026). A rare neurological manifestation of seizure in a case of anaphylaxis following a hornet sting: case report & literature review. Pamukkale Medical Journal, 19(2), 453-458. https://doi.org/10.31362/patd.1714753
AMA
1.Hazwan AE, Fauzi MH. A rare neurological manifestation of seizure in a case of anaphylaxis following a hornet sting: case report & literature review. Pam Tıp Derg. 2026;19(2):453-458. doi:10.31362/patd.1714753
Chicago
Hazwan, Azean Ermawaty, ve Mohd Hashairi Fauzi. 2026. “A rare neurological manifestation of seizure in a case of anaphylaxis following a hornet sting: case report & literature review”. Pamukkale Medical Journal 19 (2): 453-58. https://doi.org/10.31362/patd.1714753.
EndNote
Hazwan AE, Fauzi MH (01 Nisan 2026) A rare neurological manifestation of seizure in a case of anaphylaxis following a hornet sting: case report & literature review. Pamukkale Medical Journal 19 2 453–458.
IEEE
[1]A. E. Hazwan ve M. H. Fauzi, “A rare neurological manifestation of seizure in a case of anaphylaxis following a hornet sting: case report & literature review”, Pam Tıp Derg, c. 19, sy 2, ss. 453–458, Nis. 2026, doi: 10.31362/patd.1714753.
ISNAD
Hazwan, Azean Ermawaty - Fauzi, Mohd Hashairi. “A rare neurological manifestation of seizure in a case of anaphylaxis following a hornet sting: case report & literature review”. Pamukkale Medical Journal 19/2 (01 Nisan 2026): 453-458. https://doi.org/10.31362/patd.1714753.
JAMA
1.Hazwan AE, Fauzi MH. A rare neurological manifestation of seizure in a case of anaphylaxis following a hornet sting: case report & literature review. Pam Tıp Derg. 2026;19:453–458.
MLA
Hazwan, Azean Ermawaty, ve Mohd Hashairi Fauzi. “A rare neurological manifestation of seizure in a case of anaphylaxis following a hornet sting: case report & literature review”. Pamukkale Medical Journal, c. 19, sy 2, Nisan 2026, ss. 453-8, doi:10.31362/patd.1714753.
Vancouver
1.Azean Ermawaty Hazwan, Mohd Hashairi Fauzi. A rare neurological manifestation of seizure in a case of anaphylaxis following a hornet sting: case report & literature review. Pam Tıp Derg. 01 Nisan 2026;19(2):453-8. doi:10.31362/patd.1714753
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