Meme kanserli bireylerin vücut bileşimindeki kısa-dönem değişimlerin biyoelektrik empedans analizi ile incelenmesi

Öz

Amaç: Meme kanseri cerrahisi geçiren bireylerin cerrahi sonrası erken dönemde vücut kompozisyonunu incelemektir.
Gereç ve yöntem: Cerrahi planlanan 50 kadının (ortalama yaş 52.46±10.19 yıl) vücut kompozisyonu, cerrahi öncesi, 7 gün sonrası ve 6 ay sonrası biyoelektrik empedans analizi ile incelendi. Katılımcılar beden kütle indeksi <30 ve beden kütle indeksi ≥30 olanlar, aksiller lenf nodu diseksiyonu ve sentinel lenf nodu biyopsisi uygulananlar, neoajuvan kemoterapi alan ve almayanlar ile radyoterapi alan ve almayanlar şeklinde alt gruplara ayrılarak, vücut kompozisyonları karşılaştırıldı.
Bulgular: Katılımcıların ağırlık ve BKİ postoperatif azalırken, 6 ay sonrasında arttı (p<0.05). Beden kütle indeksi <30 olanların ağırlık, beden kütle indeksi, vücut yağ yüzdesi arttı (p<0.05); visseral yağ seviyesi ve vücut su oranı azaldı (p<0.05). Aksiller lenf nodu diseksiyonu yapılanların vücut yağ yüzdesi ve visseral yağ seviyesi arttı (p<0.05). Neoadjuvan kemoterapi alanların beden kütle indeksi, vücut yağ yüzdesi, visseral yağ seviyesi arttı (p<0.05); kas kütlesi ve vücut su oranı azaldı (p<0.05). Radyoterapi alanların ağırlık, beden kütle indeksi, vücut yağ yüzdesi, visseral yağ seviyesi arttı (p<0.05); vücut su oranı azaldı (p<0.05). Sentinel lenf nodu biyopsisi yapılanların, neoadjuvan kemoterapi almayanların veya radyoterapi almayanların vücut bileşimlerinde anlamlı değişim görülmedi (p>0.05).
Sonuç: Meme kanserli bireylerin vücut kompozisyonu cerrahi sonrası erken dönemde vücutta adipozite artışı yönünde değişti. Özellikle beden kütle indeksi <30 olan, aksiller lenf nodu diseksiyonu yapılan, neoadjuvan kemoterapi ve radyoterapi alan hastalarda daha belirgin değişim gözlendi.

Anahtar Kelimeler

• Meme kanseri
• vücut kompozisyonu
• beden kütle indeksi
• yağ oranı
• kas kütlesi

Etik Beyan

Çalışma için Pamukkale Üniversitesi Girişimsel Olmayan Klinik Araştırmalar Etik Kurulu'ndan 05/10/2021 tarih ve 18 sayılı (E-60116787-020-113944 sayılı) izin alındı. Projenin tüm aşamaları Helsinki Bildirgesi'ne uygun olarak yürütüldü. Katılımcılardan aydınlatılmış onam alındı.

Teşekkür

Çalışmamıza dahil olan tüm katılımcılarımıza katkı ve destekleri için teşekkür ederiz.

Investigation of short-term changes in body composition of individuals with breast cancer using bioelectrical impedance analysis

Öz

Purpose: The aim of the study was to examine the changes in body composition in the early postoperative period in individuals who underwent breast cancer surgery.
Materials and methods: The body composition of 50 women scheduled for surgery (mean age 52.46±10.19 years) was assessed using bioelectrical impedance analysis before, 7 days after, and 6 months after surgery. Participants were divided into subgroups: body mass index<30 and ≥30 group, axillary lymph node dissection and sentinel lymph node biopsy group, neoadjuvant and non-neoadjuvant chemotherapy group, and radiotherapy and non-radiotherapy group. Body compositions were compared.
Results: Participants' weight and BMI (body mass index) decreased postoperatively but increased after 6 months (p<0.05). In the BMI<30 group, weight, BMI, and body fat percentage increased (p<0.05); visceral fat level and body water percentage decreased (p<0.05). Body fat percentage and visceral fat level increased in the axillary lymph node dissection group (p<0.05). BMI, body fat percentage, and visceral fat levels increased (p<0.05); muscle mass and body water percentage decreased (p<0.05) in the neoadjuvant chemotherapy group. There were increases in the radiotherapy group; in terms of weight, BMI, body fat percentage, and visceral fat levels (p<0.05); and body water percentage decreased (p<0.05). No significant change was observed in the body composition of the sentinel lymph node biopsy group, non-neoadjuvant chemotherapy, or non-radiotherapy (p>0.05).
Conclusion: Body composition in breast cancer patients changed towards an increase in body adiposity in the early postoperative period. More pronounced changes were observed in patients with a BMI<30 who underwent axillary lymph node dissection and received neoadjuvant chemotherapy or radiotherapy.

Anahtar Kelimeler

• Breast cancer
• body composition
• body mass index
• fat ratio
• muscle mass

Etik Beyan

Permission was obtained from Pamukkale University Non-Interventional Clinical Research Ethics Committee for the study (number 18 dated 05/10/2021, E-60116787-020-113944). All stages of the project were conducted in accordance with the Helsinki Declaration. Informed consent was obtained from the participants.

Teşekkür

We would like to thank all participants in our study for their contributions and support.

Kaynakça

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