Investigation of serum magnesium, ferritin, and vitamin B12 levels in restless legs syndrome

Duygu Aras Seyit; Aylin Köseler

doi:10.31362/patd.1821143

EN TR

Investigation of serum magnesium, ferritin, and vitamin B12 levels in restless legs syndrome

Öz

Purpose: To study magnesium, ferritin, and vitamin B12 levels in patients with restless legs syndrome and assess the relationship between the disease progression and age.
Materials and methods: The retrospective data of 40 restless legs syndrome patients from 2024–2025 were analyzed. Those with chronic diseases (diabetes mellitus, chronic kidney failure, and oncological diseases) were excluded from the study. Before that, serum magnesium, ferritin and vitamin B12 levels were measured. Age was calculated, and Pearson correlation analysis was performed. Patients were followed up for 3 months.
Results: Serum magnesium levels were 2.09±0.24 mg/dL (median: 2.05 mg/dL), ferritin levels were 59.01±43.76 ng/mL (median: 49.88 ng/mL), and vitamin B12 levels were 384.88±108.72 pg/mL (median: 375.50 pg/mL). None of these biochemical parameters showed a statistically significant correlation with age (all p>0.05).
Conclusion: It was evaluated that biochemical imbalances in the restless legs syndrome symptomatology may be independent of the age factor, and that especially changes in the levels of ferritin and magnesium could be due to the pathophysiological process of the disease.

Anahtar Kelimeler

Restless legs syndrome, age, magnesium, ferritin, vitamin B12

Huzursuz bacak sendromunda serum magnezyum, ferritin ve vitamin B12 düzeylerinin araştırılması

Öz

Amaç: Huzursuz bacak sendromu hastalarında magnezyum, ferritin ve B12 vitamini düzeylerini incelemek ve hastalığın ilerlemesi ile yaş arasındaki ilişkiyi değerlendirmektir.
Gereç ve yöntem: 2024-2025 yılları arasında 40 huzursuz bacak sendromu hastasının retrospektif verileri analiz edildi. Kronik hastalığı olanlar (diyabetes mellitus, kronik böbrek yetmezliği ve onkolojik hastalıklar) çalışmadan dışlandı. Çalışma öncesinde serum magnezyum, ferritin ve B12 vitamini düzeyleri ölçüldü. Yaş hesaplandı ve Pearson korelasyon analizi yapıldı. Hastalar 3 ay boyunca takip edildi.
Bulgular: Hastaların ortalama yaşı 47,9±12,4 yıl olup, serum magnezyum düzeyi 2,09±0,24 mg/dL (medyan: 2,05 mg/dL), ferritin düzeyi 59,01±43,76 ng/mL (medyan: 49,88 ng/mL) ve B12 vitamini düzeyi 384,88±108,72 pg/mL (medyan: 375,50 pg/mL) olarak bulundu. Serum magnezyum, ferritin ve B12 vitamini düzeyleri ile yaş arasında istatistiksel olarak anlamlı bir korelasyon saptanmadı (p>0,05).
Sonuç: Huzursuz bacak sendromu semptomatolojisindeki biyokimyasal dengesizliklerin yaş faktöründen bağımsız olabileceği, özellikle ferritin ve magnezyum düzeylerindeki değişikliklerin hastalığın patofizyolojik sürecinden kaynaklanabileceği değerlendirildi.

Anahtar Kelimeler

Huzursuz bacak sendromu, yaş, magnezyum, ferritin, B12 vitamini

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Nöroloji ve Nöromüsküler Hastalıklar

Bölüm

Araştırma Makalesi

Yazarlar

Duygu Aras Seyit
0000-0003-3032-7998
Türkiye

Aylin Köseler ^*
0000-0003-4832-0436
Türkiye

Yayımlanma Tarihi

10 Ekim 2026

Gönderilme Tarihi

10 Kasım 2025

Kabul Tarihi

9 Ocak 2026

Yayımlandığı Sayı

Yıl 2026 Cilt: 19 Sayı: 4

DOI

https://doi.org/10.31362/patd.1821143

IZ

https://izlik.org/JA96GK65UN

APA

Aras Seyit, D., & Köseler, A. (2026). Investigation of serum magnesium, ferritin, and vitamin B12 levels in restless legs syndrome. Pamukkale Medical Journal, 19(4), 707-714. https://doi.org/10.31362/patd.1821143

AMA

1.Aras Seyit D, Köseler A. Investigation of serum magnesium, ferritin, and vitamin B12 levels in restless legs syndrome. Pam Tıp Derg. 2026;19(4):707-714. doi:10.31362/patd.1821143

Chicago

Aras Seyit, Duygu, ve Aylin Köseler. 2026. “Investigation of serum magnesium, ferritin, and vitamin B12 levels in restless legs syndrome”. Pamukkale Medical Journal 19 (4): 707-14. https://doi.org/10.31362/patd.1821143.

EndNote

Aras Seyit D, Köseler A (01 Ekim 2026) Investigation of serum magnesium, ferritin, and vitamin B12 levels in restless legs syndrome. Pamukkale Medical Journal 19 4 707–714.

IEEE

[1]D. Aras Seyit ve A. Köseler, “Investigation of serum magnesium, ferritin, and vitamin B12 levels in restless legs syndrome”, Pam Tıp Derg, c. 19, sy 4, ss. 707–714, Eki. 2026, doi: 10.31362/patd.1821143.

ISNAD

Aras Seyit, Duygu - Köseler, Aylin. “Investigation of serum magnesium, ferritin, and vitamin B12 levels in restless legs syndrome”. Pamukkale Medical Journal 19/4 (01 Ekim 2026): 707-714. https://doi.org/10.31362/patd.1821143.

JAMA

1.Aras Seyit D, Köseler A. Investigation of serum magnesium, ferritin, and vitamin B12 levels in restless legs syndrome. Pam Tıp Derg. 2026;19:707–714.

MLA

Aras Seyit, Duygu, ve Aylin Köseler. “Investigation of serum magnesium, ferritin, and vitamin B12 levels in restless legs syndrome”. Pamukkale Medical Journal, c. 19, sy 4, Ekim 2026, ss. 707-14, doi:10.31362/patd.1821143.

Vancouver

1.Duygu Aras Seyit, Aylin Köseler. Investigation of serum magnesium, ferritin, and vitamin B12 levels in restless legs syndrome. Pam Tıp Derg. 01 Ekim 2026;19(4):707-14. doi:10.31362/patd.1821143

Pamukkale Medical Journal Creative Commons Atıf-GayriTicari 4.0 Uluslararası Lisansı (CC BY NC) ile lisanslanmıştır.

Investigation of serum magnesium, ferritin, and vitamin B12 levels in restless legs syndrome

Öz

Anahtar Kelimeler

Huzursuz bacak sendromunda serum magnezyum, ferritin ve vitamin B12 düzeylerinin araştırılması

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

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