Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment
Öz
Study Aims: The Hepatitis B surface antigen (HBsAg) test was only used for diagnosis of hepatitis B infection, whereas now there is growing evidence favoring utilization of serum HBsAg quantitation (qHBsAg) for monitoring of infection with hepatitis B virus (HBV). In our study, we examined the courses of qHBsAg and HBV-DNA levels throughout the treatment course of patients receiving treatment for chronic hepatitis B infection and evaluated their correlation with each other.
Material and Methods: The study was performed Ankara Training and Research Hospital. A total of 71 patients receiving treatment for the diagnosis of chronic hepatitis B (CHB) infection were included in the study. Serum qHBsAg levels of these patients were analyzed with an Elecsys HBsAg II assay.
Results: When we evaluated the correlation of serum qHBsAg levels with the HBV-DNA levels among patients treated with nucleotide analogues, there was a positive correlation. The decline in both parameters at sixth and 12 month follow-up was found to be statistically significant (qHBsAg decline at 6th month: p = 0.03; qHBsAg decline at 12th month: p = 0.001; HBV-DNA decline at 6th month: p = 0.001; HBV-DNA decline at12th month: p = 0.001). In the group of patients receiving PEG-IFN treatment, there was positive correlation between the two at the end of the treatment (p = 0.01).
Conclusion: Our findings suggest that qHBsAg may be used for both the treatment decision and monitoring of treatment.
Anahtar Kelimeler
Chronic Hepatitis B, qHBsAg, PEG-IFN, , Nucleotide analogues.
Kaynakça
- 1. World Health Organization (WHO), Hepatitis B. Last accessed date 2017 Jan 5. http://www.who.int/mediacentre/factsheets/fs204/en/
- 2. Chen CJ, Yang HI, Su J, et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA. 2006;295(1):65-73.
- 3. Kohmoto M, Enomoto M, Tamori A, et al. Quantitative detection of hepatitis B surface antigen by chemiluminescent microparticle immunoassay during lamivudine treatment of chronic hepatitis B virus carriers. J Med Virol. 2005;75(2):235-9.
- 4. Moucari R, Mackiewicz V, Lada O, et al. Early serum HBsAg drop: a strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg-negative patients. Hepatology. 2009;49(4):1151-7.
- 5. Brunetto MR, Moriconi F, Bonino F, et al. Hepatitis B virus surface antigen levels: a guide to sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B. Hepatology. 2009;49(4):1141-50.
- 6. Manesis EK, Schina M, Le Gal F, et al. Quantitative analysis of hepatitis D virus RNA and hepatitis B surface antigen serum levels in chronic delta hepatitis improves treatment monitoring. Antiviral therapy. 2007;12(3):381-8.
- 7. EASL Clinical Practice Guidelines: Management of chronic hepatitis B virus infection. Journal of Hepatology 2012 vol. 57; 167–185
- 8. Health Application Declaration of Ministry of Health in Turkey, Last accessed date 2013 Jan 11, http://www.tkhk.gov.tr/Dosyalar/51ccde8184fb474fb89d1c6ce5d651ba.rar,
- 9. Tseng TC, Liu CJ, Chen CL, et al. Risk stratification of hepatocellular carcinoma in hepatitis B virus e antigen-negative carriers by combining viral biomarkers. J Infect Dis. 2013;208(4):584-93.
- 10. Tseng TC, Liu CJ, Yang HC, et al. Serum hepatitis B surface antigen levels help predict disease progression in patients with low hepatitis B virus loads. Hepatology. 2013;57(2):441-50.
