Effect of dexpanthenol on patient comfort in treatment of traumatic corneal abrasions

Öz

Objective: The aim in this study was to investigate if the use of Dexpanthenol could play a role in the relief of pain in the treatment of corneal abrasions (CA). Methods: Patients presenting to the BLINDED with a diagnosis of CA were conducted in this retrospective, case-control study. A detailed ocular examination was done and pain severity was assessed using a visual analogue scale (VAS) score. In group 1, subjects were treated with only topical ofloxacin %0.3 while subjects in group 2 were treated with topical ofloxacin %0.3 and dexpanthenol. Foreign body sensation, photophobia, excessive lacrimation and VAS were documented at follow up examinations. Results: 70 patients were allocated into group 1 and 68 patients were allocated into group 2. At each visit, there were significant differences in VAS scores between the groups (p<0.005). VAS scores were lower in group-2. There were no statistically significant differences between two groups in terms of photophobia, foreign body sensation, excessive lacrimation (p>0.05). All patients were free of any complications. Conclusion: Although it was shown that adding topical dexpanthenol to the treatment regimen could permit faster pain relief in treating CAs, the prospective studies should be done. Key words: Traumatic corneal abrasion, Dexpanthenol, Visual analogue scale.

Anahtar Kelimeler

• Traumatic corneal abrasion
• Dexpanthenol
• Visual analogue scale

Travmatik korneal abrazyon hastalarında dekspantenol kullanımının hasta konforuna olan etkisi

Öz

Amaç: Bu çalışmada amaç, Dekspantenol kullanımının travmatik kornea abrazyonlarının (KA) tedavisinde ağrının giderilmesinde etkili olabileceğini araştırmaktır. Yöntemler: Bu retrospektif, vaka kontrol çalışması KA tanısı ile KARARTILDI başvuran hastalar seçilerek yapıldı. Ayrıntılı oküler muayene yapıldı ve ağrı şiddeti görsel analog skala (GAS) skoru ile değerlendirildi. 1.grup sadece topikal ofloksasin% 0.3 ile tedavi edilirken, grup 2'deki hastalar topikal ofloksasin% 0.3 ve dekspantenol ile tedavi edildi. Takip muayenelerinde yabancı cisim hissi, fotofobi, aşırı lakrimasyon ve GAS kaydedildi. Bulgular: 70 hasta ilk grupta yeralırken, ikinci grupta 68 hasta vardı. Tüm vizitlerde GAS anlamlı olarak düşük bulundu.(p <0.001). İki grup arasında fotofobi, yabancı cisim hissi, aşırı lakrimasyon açısından istatistiksel olarak anlamlı fark yoktu (p>0.05). Sonuç: KA tedavisinde Dekspantenol eklemek ağrının azaltılmasında rol oynadığı gösterilmiş olsa da, bulguların prospektif çalışmalarla desteklenmesi gerekmektedir. Anahtar kelimeler: Travmatik korneal abrazyon, Dekspantenol, görsel ağrı skalası

Anahtar Kelimeler

• Travmatik korneal abrazyon
• Dekspantenol
• görsel ağrı skalası

Kaynakça

1. 1. (1987) Traumatic corneal abrasion. Lancet (London, England) 2:1250
2. 2. Kaiser PK (1995) A comparison of pressure patching versus no patching for corneal abrasions due to trauma or foreign body removal. Corneal Abrasion Patching Study Group. Ophthalmology 102:1936–1942
3. 3. Kirkpatrick JN, Hoh HB, Cook SD (1993) No eye pad for corneal abrasion. Eye (Lond) 7 ( Pt 3):468–471. https://doi.org/10.1038/eye.1993.95
4. 4. Hart A, White S, Conboy P, Quinton D (1997) The management of corneal abrasions in accident and emergency. Injury 28:527–529
5. 5. Wakai A, Lawrenson JG, Lawrenson AL, et al (2017) Topical non-steroidal anti-inflammatory drugs for analgesia in traumatic corneal abrasions. Cochrane database Syst Rev 5:CD009781. https://doi.org/10.1002/14651858.CD009781.pub2
6. 6. Puls HA, Cabrera D, Murad MH, et al (2015) Safety and Effectiveness of Topical Anesthetics in Corneal Abrasions: Systematic Review and Meta-Analysis. J Emerg Med 49:816–824. https://doi.org/10.1016/j.jemermed.2015.02.051
7. 7. Rao GP, Scott JA, King A, et al (1994) No eye pad for corneal abrasion. Eye (Lond). 8 ( Pt 3):371–372
8. 8. Hamdi IM (2018) Effect of D-Panthenol on Corneal Epithelial Healing after Surface Laser Ablation. J Ophthalmol 2018:6537413. https://doi.org/10.1155/2018/6537413

9. 9. Hahne M, Reichl S (2010) [Simulation of corneal epithelial injuries by mechanical and corrosive damage : Influence of fetal bovine serum and dexpanthenol on epithelial regeneration in a cell culture model]. Ophthalmologe 107:529-532,534-536. https://doi.org/10.1007/s00347-009-2079-x
10. 10. Raczynska K, Iwaszkiewicz-Bilikiewicz B, Stozkowska W, Sadlak-Nowicka J (2003) [Clinical evaluation of provitamin B5 drops and gel for postoperative treatment of corneal and conjuctival injuries]. Klin Oczna 105:175–178
11. 11. Brzheskiy V V, Popov VY, Kalinina NM, Brzheskaya I V (2018) [Prevention and treatment of degenerative changes in ocular surface epithelium in patients with dry eye syndrome]. Vestn Oftalmol 134:126–134. https://doi.org/10.17116/oftalma2018134051126
12. 12. Abiko Y, Tomikawa M, Shimizu M (1969) Enzymatic conversion of pantothenylalcohol to pantothenic acid. J Vitaminol (Kyoto) 15:59–69
13. 13. Proksch E, Holleran WM, Menon GK, et al (1993) Barrier function regulates epidermal lipid and DNA synthesis. Br J Dermatol 128:473–482
14. 14. Lai TYY, Wong VWY, Leung GM (2003) Is ophthalmology evidence based? A clinical audit of the emergency unit of a regional eye hospital. Br J Ophthalmol 87:385–390
15. 15. Lin T, Gong L (2015) Sodium hyaluronate eye drops treatment for superficial corneal abrasion caused by mechanical damage: a randomized clinical trial in the People’s Republic of China. Drug Des Devel Ther 9:687–694. https://doi.org/10.2147/DDDT.S77270
16. 16. Thiel B, Sarau A, Ng D (2017) Efficacy of Topical Analgesics in Pain Control for Corneal Abrasions: A Systematic Review. Cureus 9:e1121. https://doi.org/10.7759/cureus.1121
17. 17. Boberg-Ans G, Nissen KR (1998) Comparison of Fucithalmic viscous eye drops and Chloramphenicol eye ointment as a single treatment in corneal abrasion. Acta Ophthalmol Scand 76:108–111
18. 18. De Kaspar HM, Chang RT, Shriver EM, et al (2004) Three-day application of topical ofloxacin reduces the contamination rate of microsurgical knives in cataract surgery: a prospective randomized study. Ophthalmology 111:1352–1355. https://doi.org/10.1016/j.ophtha.2003.10.032
19. 19. Ahmed F, House RJ, Feldman BH (2015) Corneal Abrasions and Corneal Foreign Bodies. Prim Care 42:363–375. https://doi.org/10.1016/j.pop.2015.05.004
20. 20. Hobden JA, O’Callaghan RJ, Insler MS, Hill JM (1993) Ciprofloxacin ointment versus ciprofloxacin drops for therapy of experimental Pseudomonas keratitis. Cornea 12:138–141
21. 21. Chojnacki M, Philbrick A, Wucher B, et al (2019) Development of a Broad-Spectrum Antimicrobial Combination for the Treatment of Staphylococcus aureus and Pseudomonas aeruginosa Corneal Infections. Antimicrob Agents Chemother 63:. https://doi.org/10.1128/AAC.01929-18
22. 22. Eke T, Morrison DA, Austin DJ (1999) Recurrent symptoms following traumatic corneal abrasion: prevalence, severity, and the effect of a simple regimen of prophylaxis. Eye (Lond) 13 ( Pt 3a:345–347. https://doi.org/10.1038/eye.1999.87
23. 23. Le Sage N, Verreault R, Rochette L (2001) Efficacy of eye patching for traumatic corneal abrasions: a controlled clinical trial. Ann Emerg Med 38:129–134. https://doi.org/10.1067/mem.2001.115443
24. 24. Michael JG, Hug D, Dowd MD (2002) Management of corneal abrasion in children: a randomized clinical trial. Ann Emerg Med 40:67–72
25. 25. Patterson J, Fetzer D, Krall J, et al (1996) Eye patch treatment for the pain of corneal abrasion. South Med J 89:227–229
26. 26. Heller GZ, Manuguerra M, Chow R (2016) How to analyze the Visual Analogue Scale: Myths, truths and clinical relevance. Scand J pain 13:67–75. https://doi.org/10.1016/j.sjpain.2016.06.012
27. 27. Klimek L, Bergmann K-C, Biedermann T, et al (2017) Visual analogue scales (VAS): Measuring instruments for the documentation of symptoms and therapy monitoring in cases of allergic rhinitis in everyday health care: Position Paper of the German Society of Allergology (AeDA) and the German Society of Aller. Allergo J Int 26:16–24. https://doi.org/10.1007/s40629-016-0006-7
28. 28. Menghini M, Knecht PB, Kaufmann C, et al (2013) Treatment of traumatic corneal abrasions: a three-arm, prospective, randomized study. Ophthalmic Res 50:13–18. https://doi.org/10.1159/000347125
29. 29. Goyal R, Shankar J, Fone DL, Hughes DS (2001) Randomised controlled trial of ketorolac in the management of korneal abrasions. Acta Ophthalmol Scand 79:177–179. https://doi.org/10.1034/j.1600-0420.2001.079002177.x