Yıl 2020, Cilt 13 , Sayı 2, Sayfalar 415 - 423 2020-05-14

Akromegali hastalarında benign ve malign tümör sıklığı
Malign and benign tumor frequency in patients with acromegaly

Nusret YILMAZ [1] , Gökhan TAZEGÜL [2] , Ramazan SARI [3] , Hasan Ali ALTUNBAŞ [4] , Mustafa Kemal BALCI [5]


Amaç: Bu çalışmada tek bir merkezde izlenen akromegali hastalarındaki benign ve malign tümör sıklığının belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Toplam 92 akromegali hastasının kayıtları retrospektif olarak incelendi. Hastaların temel klinik karakteristikleri ile hastalarda mevcut olan benign ve malign tümörlerin özellikleri ve sıklıkları değerlendirildi. Bulgular: Hastaların medyan yaşları 51 (26-83) yıl , 52’si (%56,5) kadın ve 40’ı (%43,5) erkek idi. Hastaların %4,3’ünde (n=4) malignite mevcuttu. Saptanan malignitelerin tümü tiroid papiller karsinomu idi. Hastaların %76,1’inde en az bir benign tümör vardı. Tiroid ultrasonografisi (USG) yapılan hastaların (n=74) %76’sında (n=57) tiroid nodülü, kolonoskopi yapılan hastaların (n=70) %21,4’ünde (n=15) kolon polipi, abdominal USG yapılan hastaların (n=72) %5,5’inde (n=4) safra kesesi polipi, meme görüntülemesi yapılan kadınların (n=52) %11,5’inde (n=6) benign meme lezyonu mevcuttu. Sonuç: Sonuç olarak akromegali hastalarında artmış tiroid nodülü ve tiroid kanseri riski mevcuttur. Bu nedenle akromegali hastaları tiroid nodülü yönünden aktif olarak izlenmeli, USG’de şüpheli bulgular saptanması durumunda ince iğne aspirasyon biyopsisi ile değerlendirilmelidir.
Purpose: The aim of this study was to determine the prevalence of benign and malignant tumors in acromegaly patients in a single center. Materials and Methods: Records of 92 patients with acromegaly were retrospectively reviewed. Main clinical characteristics of the patients and characteristics and frequency of benign and malignant tumors were evaluated. Results: Median age of patients was 51 (26-83) years, 52 (56.5%) were female and 40 (43.5%) were male. 4.3% (n=4) of the patients had a malignancy. All malignancies were thyroid papillary carcinoma. 76.1% of the patients had at least one benign tumor. Of patients underwent specific imaging modalities, thyroid nodules was present in 76% (n=57) of patients who underwent thyroid ultrasography (n=74), colon polyps was present in 21.4% (n=15) of patients who underwent colonoscopy (n=70), gallbladder polyps were present in 5.5% (n = 4) of patients who underwent abdominal ultrasonography (n=72) and benign breast lesions were found in 11.5% (n=6) of women who underwent breast imaging (n=52). Conclusion: There is an increased risk of thyroid nodules and thyroid cancer in patients with acromegaly. Therefore, acromegaly patients should be actively monitored for thyroid nodules, and if suspicious findings are detected on ultrasonography, they should be evaluated further.
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Birincil Dil tr
Konular Endokrinoloji ve Metabolizma
Yayımlanma Tarihi Mayıs 2020
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0002-7494-1562
Yazar: Nusret YILMAZ (Sorumlu Yazar)
Kurum: Akdeniz Üniversitesi Tıp Fakültesi Endokrinoloji ve Metabolizma Hastalıkları Bilim Dalı
Ülke: Turkey


Orcid: 0000-0002-0737-9450
Yazar: Gökhan TAZEGÜL
Kurum: Akdeniz Üniversitesi Tıp Fakültesi İç Hastalıkları Ana Bilim Dalı
Ülke: Turkey


Orcid: 0000-0002-6989-1492
Yazar: Ramazan SARI
Kurum: Akdeniz Üniversitesi Tıp Fakültesi Endokrinoloji ve Metabolizma Hastalıkları Bilim Dalı
Ülke: Turkey


Orcid: 0000-0002-9468-6888
Yazar: Hasan Ali ALTUNBAŞ
Kurum: Akdeniz Üniversitesi Tıp Fakültesi Endokrinoloji ve Metabolizma Hastalıkları Bilim Dalı
Ülke: Turkey


Orcid: 0000-0002-6494-3249
Yazar: Mustafa Kemal BALCI
Kurum: Akdeniz Üniversitesi Tıp Fakültesi Endokrinoloji ve Metabolizma Hastalıkları Bilim Dalı
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 14 Mayıs 2020

Bibtex @araştırma makalesi { patd656681, journal = {Pamukkale Tıp Dergisi}, issn = {}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2020}, volume = {13}, pages = {415 - 423}, doi = {10.31362/patd.656681}, title = {Akromegali hastalarında benign ve malign tümör sıklığı}, key = {cite}, author = {YILMAZ, Nusret and TAZEGÜL, Gökhan and SARI, Ramazan and ALTUNBAŞ, Hasan and BALCI, Mustafa} }
APA YILMAZ, N , TAZEGÜL, G , SARI, R , ALTUNBAŞ, H , BALCI, M . (2020). Akromegali hastalarında benign ve malign tümör sıklığı. Pamukkale Tıp Dergisi , 13 (2) , 415-423 . DOI: 10.31362/patd.656681
MLA YILMAZ, N , TAZEGÜL, G , SARI, R , ALTUNBAŞ, H , BALCI, M . "Akromegali hastalarında benign ve malign tümör sıklığı". Pamukkale Tıp Dergisi 13 (2020 ): 415-423 <https://dergipark.org.tr/tr/pub/patd/issue/54327/656681>
Chicago YILMAZ, N , TAZEGÜL, G , SARI, R , ALTUNBAŞ, H , BALCI, M . "Akromegali hastalarında benign ve malign tümör sıklığı". Pamukkale Tıp Dergisi 13 (2020 ): 415-423
RIS TY - JOUR T1 - Akromegali hastalarında benign ve malign tümör sıklığı AU - Nusret YILMAZ , Gökhan TAZEGÜL , Ramazan SARI , Hasan Ali ALTUNBAŞ , Mustafa Kemal BALCI Y1 - 2020 PY - 2020 N1 - doi: 10.31362/patd.656681 DO - 10.31362/patd.656681 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 415 EP - 423 VL - 13 IS - 2 SN - -1308-0865 M3 - doi: 10.31362/patd.656681 UR - https://doi.org/10.31362/patd.656681 Y2 - 2020 ER -
EndNote %0 Pamukkale Tıp Dergisi Akromegali hastalarında benign ve malign tümör sıklığı %A Nusret YILMAZ , Gökhan TAZEGÜL , Ramazan SARI , Hasan Ali ALTUNBAŞ , Mustafa Kemal BALCI %T Akromegali hastalarında benign ve malign tümör sıklığı %D 2020 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 13 %N 2 %R doi: 10.31362/patd.656681 %U 10.31362/patd.656681
ISNAD YILMAZ, Nusret , TAZEGÜL, Gökhan , SARI, Ramazan , ALTUNBAŞ, Hasan , BALCI, Mustafa . "Akromegali hastalarında benign ve malign tümör sıklığı". Pamukkale Tıp Dergisi 13 / 2 (Mayıs 2020): 415-423 . https://doi.org/10.31362/patd.656681
AMA YILMAZ N , TAZEGÜL G , SARI R , ALTUNBAŞ H , BALCI M . Akromegali hastalarında benign ve malign tümör sıklığı. Pamukkale Tıp Dergisi. 2020; 13(2): 415-423.
Vancouver YILMAZ N , TAZEGÜL G , SARI R , ALTUNBAŞ H , BALCI M . Akromegali hastalarında benign ve malign tümör sıklığı. Pamukkale Tıp Dergisi. 2020; 13(2): 423-415.