Yıl 2020, Cilt 13 , Sayı 3, Sayfalar 569 - 578 2020-09-18

Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment
Tedavi alan kronik hepatit B hastalarında serum kantitatif HBsAg düzeyi ile viral yük arasındaki ilişkinin araştırılması

Meryem DEMİRELLİ [1] , Necla TÜLEK [2] , Fatih TEMOÇİN [3] , Doğan YÜCEL [4] , Şebnem ERDİNÇ [5] , Gunay ERTEM [6]


Study Aims: The Hepatitis B surface antigen (HBsAg) test was only used for diagnosis of hepatitis B infection, whereas now there is growing evidence favoring utilization of serum HBsAg quantitation (qHBsAg) for monitoring of infection with hepatitis B virus (HBV). In our study, we examined the courses of qHBsAg and HBV-DNA levels throughout the treatment course of patients receiving treatment for chronic hepatitis B infection and evaluated their correlation with each other. Material and Methods: The study was performed Ankara Training and Research Hospital. A total of 71 patients receiving treatment for the diagnosis of chronic hepatitis B (CHB) infection were included in the study. Serum qHBsAg levels of these patients were analyzed with an Elecsys HBsAg II assay. Results: When we evaluated the correlation of serum qHBsAg levels with the HBV-DNA levels among patients treated with nucleotide analogues, there was a positive correlation. The decline in both parameters at sixth and 12 month follow-up was found to be statistically significant (qHBsAg decline at 6th month: p = 0.03; qHBsAg decline at 12th month: p = 0.001; HBV-DNA decline at 6th month: p = 0.001; HBV-DNA decline at12th month: p = 0.001). In the group of patients receiving PEG-IFN treatment, there was positive correlation between the two at the end of the treatment (p = 0.01). Conclusion: Our findings suggest that qHBsAg may be used for both the treatment decision and monitoring of treatment.
ÖZET Amaç: Yakın geçmişe kadar HBsAg sadece hepatit B enfeksiyonun tanısında kullanılırken, günümüzde serum HBsAg kantitasyonu (qHBsAg)’nun, hepatit B virüsü (HBV) enfeksiyonunun viral monitörizasyonunda kullanılabileceğine dair veriler artmaya başlamıştır. Bu çalışmada inaktif hepatit B taşıyıcıları ile kronik aktif hepatit B hastaları arasındaki qHBsAg ile HBV DNA düzeyleri karşılaştırılmış ve tedavi başlanmış hastalarda tedavi süresince qHBsAg ile HBVDNA seyri izlenerek aralarındaki ilişki değerlendirilmiştir. Materyal ve Metod: Çalışma Ankara Eğitim ve Araştırma Hastanesi Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji kliniği’nde yapılmıştır. Kronik hepatit B (KHB) tanısıyla tedavi alan 71 hasta ve inaktif HBsAg taşıyıcısı 74 hasta çalışmaya dahil edildi. Bu hastalarda serum qHBsAg düzeyleri Elecsys HBsAg II cihazı ile çalışıldı. Bulgular: Nükleoz(t)id analoğu ile tedavi edilen hastalarda 6. ve 12. aydaki serum qHBsAg düzeyi ile HBV-DNA arasında pozitif yönde bir korelasyon görüldü ve her iki parametrenin altı ay ve bir yıllık izlemindeki düşüş istatiksel olarak anlamlı bulundu (qHBsAg 6ay p=0,03, qHBsAg 12 ay p=0,001, HBV DNA 6 ay p=0,001, HBV DNA 12 ay p=0,001). Peg-IFN tedavisi alan kronik hepatit B hastalarında ise serum qHBsAg düzeyi ile HBV-DNA arasında tedavi başlangıcı ve 6. ayında anlamlı bir ilişki olmayıp tedavi sonunda pozitif yönde korelasyon görüldü. PEG-IFN tedavisi alan hasta grubunda ise qHBsAg seviyeleri ile HBV DNA arasındaki korelasyon tedavi sonunda anlamlı (p=0,01) olarak saptandı. Sonuç: Bizim bulgularımız qHBsAg’nin, inaktif HBsAg taşıyıcıları ve KHB hastalarını ayırmada HBV-DNA düzeyleri birlikte kullanıldığında oldukça faydalı bir test olabileceği ve tedavi kararında ve takibinde qHBSAg seviyelerinin kullanılabileceğini düşündürmektedir.
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Birincil Dil en
Konular Enfeksiyon Hastalıkları
Yayınlanma Tarihi Eylül 2020
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0003-2973-7965
Yazar: Meryem DEMİRELLİ
Kurum: Bafra State Hospital
Ülke: Turkey


Orcid: 0000-0002-3952-4982
Yazar: Necla TÜLEK
Kurum: ATILIM UNIVERSITY
Ülke: Turkey


Orcid: 0000-0002-4819-8242
Yazar: Fatih TEMOÇİN (Sorumlu Yazar)
Kurum: ONDOKUZ MAYIS UNIVERSITY
Ülke: Turkey


Orcid: 0000-0001-5487-2857
Yazar: Doğan YÜCEL
Kurum: Ankara Training and Research Hospital, Infectious
Ülke: Turkey


Orcid: 0000-0003-3918-564X
Yazar: Şebnem ERDİNÇ
Kurum: Ankara Training and Research Hospital
Ülke: Turkey


Orcid: 0000-0001-8760-0030
Yazar: Gunay ERTEM
Kurum: Ankara Training and Research Hospital
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 18 Eylül 2020

Bibtex @araştırma makalesi { patd691645, journal = {Pamukkale Tıp Dergisi}, issn = {}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2020}, volume = {13}, pages = {569 - 578}, doi = {10.31362/patd.691645}, title = {Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment}, key = {cite}, author = {Demi̇relli̇, Meryem and Tülek, Necla and Temoçi̇n, Fatih and Yücel, Doğan and Erdi̇nç, Şebnem and Ertem, Gunay} }
APA Demi̇relli̇, M , Tülek, N , Temoçi̇n, F , Yücel, D , Erdi̇nç, Ş , Ertem, G . (2020). Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment . Pamukkale Tıp Dergisi , 13 (3) , 569-578 . DOI: 10.31362/patd.691645
MLA Demi̇relli̇, M , Tülek, N , Temoçi̇n, F , Yücel, D , Erdi̇nç, Ş , Ertem, G . "Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment" . Pamukkale Tıp Dergisi 13 (2020 ): 569-578 <https://dergipark.org.tr/tr/pub/patd/issue/55097/691645>
Chicago Demi̇relli̇, M , Tülek, N , Temoçi̇n, F , Yücel, D , Erdi̇nç, Ş , Ertem, G . "Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment". Pamukkale Tıp Dergisi 13 (2020 ): 569-578
RIS TY - JOUR T1 - Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment AU - Meryem Demi̇relli̇ , Necla Tülek , Fatih Temoçi̇n , Doğan Yücel , Şebnem Erdi̇nç , Gunay Ertem Y1 - 2020 PY - 2020 N1 - doi: 10.31362/patd.691645 DO - 10.31362/patd.691645 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 569 EP - 578 VL - 13 IS - 3 SN - -1308-0865 M3 - doi: 10.31362/patd.691645 UR - https://doi.org/10.31362/patd.691645 Y2 - 2020 ER -
EndNote %0 Pamukkale Tıp Dergisi Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment %A Meryem Demi̇relli̇ , Necla Tülek , Fatih Temoçi̇n , Doğan Yücel , Şebnem Erdi̇nç , Gunay Ertem %T Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment %D 2020 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 13 %N 3 %R doi: 10.31362/patd.691645 %U 10.31362/patd.691645
ISNAD Demi̇relli̇, Meryem , Tülek, Necla , Temoçi̇n, Fatih , Yücel, Doğan , Erdi̇nç, Şebnem , Ertem, Gunay . "Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment". Pamukkale Tıp Dergisi 13 / 3 (Eylül 2020): 569-578 . https://doi.org/10.31362/patd.691645
AMA Demi̇relli̇ M , Tülek N , Temoçi̇n F , Yücel D , Erdi̇nç Ş , Ertem G . Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment. Pamukkale Tıp Dergisi. 2020; 13(3): 569-578.
Vancouver Demi̇relli̇ M , Tülek N , Temoçi̇n F , Yücel D , Erdi̇nç Ş , Ertem G . Investigation of the association of serum quantitative HBsAg levels with viral load in chronic hepatitis B Patients receiving treatment. Pamukkale Tıp Dergisi. 2020; 13(3): 569-578.