Yıl 2020, Cilt 13 , Sayı 3, Sayfalar 715 - 721 2020-09-18

Polikistik over sendrom'lu hastalarda Pancreatic derived factor ve Malondialdehit düzeylerinin incelenmesi
The evaluation of serum Pancreatic-derived factor and Malondialdehyde levels in patients with polycystic ovary syndrome

Ümit ÇABUŞ [1] , Babür KALELİ [2] , İ.veysel FENKCİ [3] , İlknur KALELİ [4] , Süleyman DEMİR [5]


Amaç: β hücrelerinin fonksiyonlarındaki değişiklikler polikistik over sendromunun (PCOS) patogenezinde önemli roller oynayabilir. Pankreatic Derived Factor (PANDER), patolojik koşullar altında pankreatik β hücre apoptozunu indükleyen sitokin benzeri bir proteindir. Bu araştırma, serum PANDER düzeylerini belirlemek ve serum PANDER düzeylerinin oksidatif stres ve PCOS'taki insülin direnci ile ilişkili olup olmadığını belirlemek için planlanmıştır. Gereç ve Yöntem: Bu kontrollü klinik çalışmada PKOS tanısı almış 27 hasta ve 24 sağlıklı kadın control grubu olarak değerlendirildi. Serum lipit alt fraksiyonları, açlık glikozu, insülin, gonadotropinler ve androjenler, malondialdehit (MDA) ve PANDER düzeyleri ölçüldü. İnsülin direncini tahmin etmek için homeostaz model değerlendirmesi (HOMA-IR) kullanıldı. Bulgular: Çalışma ve kontrol grubundaki denekler bel ölçümleri, gonadotropinler, lipit alt fraksiyonları, MDA ve PANDER düzeyleri açısından benzerdi, PKOS'lu kadınlar sağlıklı kadınlardan önemli ölçüde daha yüksek FAI ve HOMA-IR'ye sahipti. Serum PANDER düzeyleri çalışılan parametrelerle ilişkili değildi. Sonuç: Bu sonuçlar PANDER seviyesinin PCOS'ta insülin direnci, over kaynaklı hiperandrojenizm ve oksidatif stres ile ilişkili olmadığını göstermiştir.
Purpose: Alterations in β-cell function may play crucial roles in the pathogenesis of polycystic ovary syndrome (PCOS). Pancreatic-derived factor (PANDER) is a cytokine-like protein, inducing of pancreatic β-cell apoptosis under pathological conditions. This investigation was planned to determine serum PANDER levels and establish whether serum PANDER levels are related with oxidative stress, and insulin resistance in PCOS. Materials and Methods: Twenty-seven patients with PCOS and 24 healthy control women were evaluated in this controlled clinical study. Serum lipid sub-fractions, fasting glucose, insulin, gonadotropins, androgens, malondialdehyde (MDA) and PANDER levels were measured. Homeostasis model assessment (HOMA-IR) were used to estimate insulin resistance. Results: Subjects in study and control groups were similar with respect to waist measurements, gonadotropins, lipid sub-fractions, MDA and PANDER levels, the women with PCOS had considerably higher FAI and HOMA-IR than healthy women. Serum PANDER levels were not correlated with any studied parameters. Conclusion: These outcomes showed that PANDER level is not related with insulin resistance, ovarian hyperandrogenism and oxidative stress in PCOS.
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Birincil Dil en
Konular Kadın Hastalıkları ve Doğum
Yayınlanma Tarihi Eylül 2020
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0001-5478-5673
Yazar: Ümit ÇABUŞ (Sorumlu Yazar)
Kurum: Pamukkale Üniversitesi Tıp Fakültesi, Kadın Hastalıkları Doğum AD
Ülke: Turkey


Orcid: 0000-0002-5122-9329
Yazar: Babür KALELİ
Kurum: Pamukkale Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum AD
Ülke: Turkey


Orcid: 0000-0003-4929-5252
Yazar: İ.veysel FENKCİ
Kurum: Pamukkale Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum AD
Ülke: Turkey


Orcid: 0000-0001-9689-8297
Yazar: İlknur KALELİ
Kurum: Pamukkale Üniversitesi Tıp Fakültesi Tıbbi Mikrobiyoloji AD
Ülke: Turkey


Orcid: 0000-0003-4156-4040
Yazar: Süleyman DEMİR
Kurum: Pamukkale Üniversitesi Tıp Fakültesi Tıbbi Biyokimya AD
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 18 Eylül 2020

Bibtex @araştırma makalesi { patd699953, journal = {Pamukkale Tıp Dergisi}, issn = {}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2020}, volume = {13}, pages = {715 - 721}, doi = {10.31362/patd.699953}, title = {The evaluation of serum Pancreatic-derived factor and Malondialdehyde levels in patients with polycystic ovary syndrome}, key = {cite}, author = {Çabuş, Ümit and Kaleli̇, Babür and Fenkci̇, İ.veysel and Kaleli̇, İlknur and Demi̇r, Süleyman} }
APA Çabuş, Ü , Kaleli̇, B , Fenkci̇, İ , Kaleli̇, İ , Demi̇r, S . (2020). The evaluation of serum Pancreatic-derived factor and Malondialdehyde levels in patients with polycystic ovary syndrome . Pamukkale Tıp Dergisi , 13 (3) , 715-721 . DOI: 10.31362/patd.699953
MLA Çabuş, Ü , Kaleli̇, B , Fenkci̇, İ , Kaleli̇, İ , Demi̇r, S . "The evaluation of serum Pancreatic-derived factor and Malondialdehyde levels in patients with polycystic ovary syndrome" . Pamukkale Tıp Dergisi 13 (2020 ): 715-721 <https://dergipark.org.tr/tr/pub/patd/issue/55097/699953>
Chicago Çabuş, Ü , Kaleli̇, B , Fenkci̇, İ , Kaleli̇, İ , Demi̇r, S . "The evaluation of serum Pancreatic-derived factor and Malondialdehyde levels in patients with polycystic ovary syndrome". Pamukkale Tıp Dergisi 13 (2020 ): 715-721
RIS TY - JOUR T1 - The evaluation of serum Pancreatic-derived factor and Malondialdehyde levels in patients with polycystic ovary syndrome AU - Ümit Çabuş , Babür Kaleli̇ , İ.veysel Fenkci̇ , İlknur Kaleli̇ , Süleyman Demi̇r Y1 - 2020 PY - 2020 N1 - doi: 10.31362/patd.699953 DO - 10.31362/patd.699953 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 715 EP - 721 VL - 13 IS - 3 SN - -1308-0865 M3 - doi: 10.31362/patd.699953 UR - https://doi.org/10.31362/patd.699953 Y2 - 2020 ER -
EndNote %0 Pamukkale Tıp Dergisi The evaluation of serum Pancreatic-derived factor and Malondialdehyde levels in patients with polycystic ovary syndrome %A Ümit Çabuş , Babür Kaleli̇ , İ.veysel Fenkci̇ , İlknur Kaleli̇ , Süleyman Demi̇r %T The evaluation of serum Pancreatic-derived factor and Malondialdehyde levels in patients with polycystic ovary syndrome %D 2020 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 13 %N 3 %R doi: 10.31362/patd.699953 %U 10.31362/patd.699953
ISNAD Çabuş, Ümit , Kaleli̇, Babür , Fenkci̇, İ.veysel , Kaleli̇, İlknur , Demi̇r, Süleyman . "The evaluation of serum Pancreatic-derived factor and Malondialdehyde levels in patients with polycystic ovary syndrome". Pamukkale Tıp Dergisi 13 / 3 (Eylül 2020): 715-721 . https://doi.org/10.31362/patd.699953
AMA Çabuş Ü , Kaleli̇ B , Fenkci̇ İ , Kaleli̇ İ , Demi̇r S . The evaluation of serum Pancreatic-derived factor and Malondialdehyde levels in patients with polycystic ovary syndrome. Pamukkale Tıp Dergisi. 2020; 13(3): 715-721.
Vancouver Çabuş Ü , Kaleli̇ B , Fenkci̇ İ , Kaleli̇ İ , Demi̇r S . The evaluation of serum Pancreatic-derived factor and Malondialdehyde levels in patients with polycystic ovary syndrome. Pamukkale Tıp Dergisi. 2020; 13(3): 715-721.