Yıl 2020, Cilt 13 , Sayı 3, Sayfalar 593 - 604 2020-09-18

Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi
Evaluation of osteoporosis and the risk of secondary fractures in postmenopausal 55- 60 years old patients with type-2 diabetes mellitus

Oğuzhan AKSU [1] , Digdem AYDIN YILMAZ [2]


Tip 2 DM hastalarda KMD değerlerinden bağımsız olarak kırık riskinde artış olduğunu gösteren meta analizler mevcuttur. Diyabette kemik frajilitesindeki artış pentosidin ile ilişkilendirilmiştir. Çalışmamızda postmenopozal Tip 2 DM hastalarda kontrol grubuna göre diyabete bağlı olarak artmış kırık riskini ortaya koymak için WHO FRAX ölçeğini kullanarak hesapladığımız kırık riski yüzdesi ile kemik turnover belirteçleri, sclerostin ve pentosidin düzeylerinin ilişkisini göstermeyi planladık. Çalışmaya 55-65 yaş arası 80 postmenopozal kadın alındı. 50 kişi Tip 2 DM grubuna ve 30 kişi (DM olmayan) kontrol grubuna alındı. Çalışmaya sekonder osteoporoz nedenlerine sahip hastalar alınmadı. Diyabetik ve kontrol grubu arasında kırık riski yüzdeleri ve kemik turnover belirteçleri, pentosidin, sclerostin düzeyleri arasında anlamlı fark saptanmadı. Ayrıca kırık riski yüzdesi, KMD değerleri ile serumda bakılan belirteçler arasında korelasyon saptanmadı. Diyabetik hastalarda osteoporoza bağlı kırık riskini değerlendirmede KMD yetersiz olup, kandaki belirteçlerden faydalanılması ve FRAX a entegre edilebilmesi için yeni çalışmalara ihtiyaç vardır. There are some meta analysis about high fracture risk in type 2 DM group, independent of high BMD values. Fracture risk in DM; related with Pentosidine. In this study we aimed to determine whether there is a relation between bone turnover markers, pentosidin, sclerostin and increased fracture risk, calculated with WHO FRAX algoritm. In totaly, 80 postmenupausal women between ages 55-65 were included to this study. 50 patients with type 2 DM for DM group and 30 patients choosed for control group. Patients who have seconder osteoporosis were excluded. As a result of study there was no significant difference between with diabetics and control group as following parameters: Bone turnover markers, pentosidin and sclerostin levels and fracture risk percentages. Morover, among the markers assesed by fracture risk persentages no significant correlation determined.
Osteoporoz, Tip 2 DM de fraktür riski, pentosidin, sclerostin
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Birincil Dil tr
Konular Endokrinoloji ve Metabolizma
Yayınlanma Tarihi Eylül 2020
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0003-4666-7129
Yazar: Oğuzhan AKSU (Sorumlu Yazar)
Kurum: Aydın Devlet Hastanesi Endokrinoloji ve Metabolizma Hastalıkları
Ülke: Turkey


Orcid: 0000-0002-7981-8045
Yazar: Digdem AYDIN YILMAZ
Kurum: Şehit Prof. Dr. İlhan Varank Sancaktepe Eğitim Araştırma Hastanesi
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 18 Eylül 2020

Bibtex @araştırma makalesi { patd709909, journal = {Pamukkale Tıp Dergisi}, issn = {}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2020}, volume = {13}, pages = {593 - 604}, doi = {10.31362/patd.709909}, title = {Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi}, key = {cite}, author = {Aksu, Oğuzhan and Aydın, Digdem} }
APA Aksu, O , Aydın, D . (2020). Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi . Pamukkale Tıp Dergisi , 13 (3) , 593-604 . DOI: 10.31362/patd.709909
MLA Aksu, O , Aydın, D . "Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi" . Pamukkale Tıp Dergisi 13 (2020 ): 593-604 <https://dergipark.org.tr/tr/pub/patd/issue/55097/709909>
Chicago Aksu, O , Aydın, D . "Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi". Pamukkale Tıp Dergisi 13 (2020 ): 593-604
RIS TY - JOUR T1 - Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi AU - Oğuzhan Aksu , Digdem Aydın Y1 - 2020 PY - 2020 N1 - doi: 10.31362/patd.709909 DO - 10.31362/patd.709909 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 593 EP - 604 VL - 13 IS - 3 SN - -1308-0865 M3 - doi: 10.31362/patd.709909 UR - https://doi.org/10.31362/patd.709909 Y2 - 2020 ER -
EndNote %0 Pamukkale Tıp Dergisi Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi %A Oğuzhan Aksu , Digdem Aydın %T Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi %D 2020 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 13 %N 3 %R doi: 10.31362/patd.709909 %U 10.31362/patd.709909
ISNAD Aksu, Oğuzhan , Aydın, Digdem . "Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi". Pamukkale Tıp Dergisi 13 / 3 (Eylül 2020): 593-604 . https://doi.org/10.31362/patd.709909
AMA Aksu O , Aydın D . Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi. Pamukkale Tıp Dergisi. 2020; 13(3): 593-604.
Vancouver Aksu O , Aydın D . Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi. Pamukkale Tıp Dergisi. 2020; 13(3): 593-604.