Yıl 2020, Cilt 13 , Sayı 3, Sayfalar 759 - 766 2020-09-18

Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential biomarkers of acute exacerbation in children with non-cystic fibrosis bronchiectasis
Nötrofil- lenfosit oranı ve trombosit- lenfosit oranlarının çocuklardaki kistik fibroz dışı bronşektazinin akut alevlenmesinde potansiyel biyolojik gösterge olarak değerlendirmesi

Ayse Ayzıt KILINÇ [1] , Gulizar ALİSHBAYLİ [2] , Nursena KOLOGLU [3] , Haluk ÇOKUĞRAŞ [4]


Purpose: Non- cyctic fibrosis bronchiectasis (non-CFBE) is a chronic inflammatory lung disease which causes significant morbidity in children. Exacerbations in non-CFBE are associated with worsening lung function. Several laboratory parameters such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) have been suggested to be as an indicator in various chronic inflammatory diseases. We aimed to asses the value of the NLR, PLR and MPV as markers of acute exacerbation in pediatric patients with non-CFBE. Methods: The NLR, PLR, and MPV values of 55 non-CFBE patients (during exacerbation and stable state periods) and 79 healthy control subjects were analyzed. Results: The mean ages for the patient and control group were 13.62±3.5 and 12.72±2.68 years, respectively. 64% of patients and 54% of control subjects were male. The white blood cell count, absolute neutrophil count, and NLR values were significantly higher in the exacerbation group than in the healthy control group (p<0.05). MPV and PLR values were not significantly different between the two groups. Only forced expiratory volume in one second (FEV1) and C-reactive protein level were significantly different (p<0.001) between the acute exacerbation and stable state periods in the Purpose: Non- cyctic fibrosis bronchiectasis (non-CFBE) is a chronic inflammatory lung disease which causes significant morbidity in children. Exacerbations in non-CFBE are associated with worsening lung function. Several laboratory parameters such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) have been suggested to be as an indicator in various chronic inflammatory diseases. We aimed to asses the value of the NLR, PLR and MPV as markers of acute exacerbation in pediatric patients with non-CFBE.

Methods: The NLR, PLR, and MPV values of 55 non-CFBE patients (during exacerbation and stable state periods) and 79 healthy control subjects were analyzed.

Results: The mean ages for the patient and control group were 13.62±3.5 and 12.72±2.68 years, respectively. 64% of patients and 54% of control subjects were male. The white blood cell count, absolute neutrophil count, and NLR values were significantly higher in the exacerbation group than in the healthy control group (p<0.05). MPV and PLR values were not significantly different between the two groups. Only forced expiratory volume in one second (FEV1) and C-reactive protein level were significantly different (p<0.001) between the acute exacerbation and stable state periods in the patient group. Conclusion: Despite the NLR value being significantly higher in children with non-CFBE than in healthy control subjects, it did not differentiate between the steady-state and acute exacerbations periods of the disease. PLR and MPV values also cannot be used as markers of acute exacerbation in children with non-CFBE.

Özet

Amaç: Kistik fibroz dışı bronsektazi (KFDBE) çocuklarda önemli morbiditeye yol açan kronik inflamatuar akciğer hastalığıdır. KFDBE'de alevlenme akciğer fonksiyonlarının kötüye gitmesi ile ilişkilidir. Nötrofil- lenfosit oranı (NLO), trombosit- lenfosit oranı (TLO) ve ortalama trombosit hacmi (OTH) gibi bazı laboratuar parametrelerinin çesitli kronik inflamatuar hastalıkları için bir gösterge olduğu öne sürülmüştür. Çalışmamızda, KFDBE’li çocuklardaki akut alevlenmede NLO, TLO ve OTH ölçümlerinin bir gösterge olarak değerlendirilmesini amaçladık.

Gereç ve yöntem: Çalışmada, akut alevlenme ve stabil dönemdeki 55 KFDBE' li hastanın ve 79 sağlıklı kontrol grubunun NLO, TLO ve OTH değerleri analiz edildi.

Bulgular: Çalışma ve kontrol grubundaki hastaların ortalama yaşları sırasıyla 13,62±3,5 ve 12,72±2,68 yıldı. Çalışma grubunun %64'ü ve kontrol grubunun %54'ü erkekti. Alevlenme dönemindeki grupta beyaz küre sayısı, nötrofil oranı ve NLO değerleri sağlıklı kontrol grubundan anlamlı olarak yüksekti (p<0,05). İki gruptaki TLO ve OTH değerleri arasında anlamli fark yoktu. Çalışma grubunun akut alevlenme ve stabil dönemleri arasında, sadece ilk bir saniyede zorlu ekspiryum hacmi (FEV1) ve c-reaktif protein (CRP) seviyeleri arasında anlamlı fark vardı (p<0,001).

Sonuç: Her ne kadar KFDBE' li çocuklardaki NLO değeri sağlıklı kontrol grubundaki çocuklara göre anlamlı ölçüde yüksek olsa da hastalığın stabil durum ve akut alevlenme periyodu arasında NLO değeri farklılık göstermedi. TLO ve OTH değerleri, KFDBE'li çocuklardaki akut alevlenmelerde bir gösterge olarak kullanılamaz.

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Birincil Dil en
Konular Pediatri
Yayınlanma Tarihi Eylül 2020
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0002-2879-8910
Yazar: Ayse Ayzıt KILINÇ (Sorumlu Yazar)
Kurum: ISTANBUL UNIVERSITY, CERRAHPAŞA FACULTY OF MEDICINE, CERRAHPAŞA MEDICINE PR.
Ülke: Turkey


Orcid: 0000-0003-4460-7309
Yazar: Gulizar ALİSHBAYLİ
Kurum: ISTANBUL UNIVERSITY, CERRAHPAŞA FACULTY OF MEDICINE, CERRAHPAŞA MEDICINE PR.
Ülke: Turkey


Orcid: 0000-0003-2227-5200
Yazar: Nursena KOLOGLU
Kurum: ISTANBUL UNIVERSITY, CERRAHPAŞA FACULTY OF MEDICINE, CERRAHPAŞA MEDICINE PR.
Ülke: Turkey


Orcid: 0000-0002-0086-3936
Yazar: Haluk ÇOKUĞRAŞ
Kurum: ISTANBUL UNIVERSITY, CERRAHPAŞA FACULTY OF MEDICINE, CERRAHPAŞA MEDICINE PR. (ENGLISH)
Ülke: Turkey


Destekleyen Kurum yok
Proje Numarası yok
Teşekkür yok
Tarihler

Yayımlanma Tarihi : 18 Eylül 2020

Bibtex @araştırma makalesi { patd752594, journal = {Pamukkale Tıp Dergisi}, issn = {}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2020}, volume = {13}, pages = {759 - 766}, doi = {10.31362/patd.752594}, title = {Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential biomarkers of acute exacerbation in children with non-cystic fibrosis bronchiectasis}, key = {cite}, author = {Kılınç, Ayse Ayzıt and Ali̇shbayli̇, Gulizar and Kologlu, Nursena and Çokuğraş, Haluk} }
APA Kılınç, A , Ali̇shbayli̇, G , Kologlu, N , Çokuğraş, H . (2020). Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential biomarkers of acute exacerbation in children with non-cystic fibrosis bronchiectasis . Pamukkale Tıp Dergisi , 13 (3) , 759-766 . DOI: 10.31362/patd.752594
MLA Kılınç, A , Ali̇shbayli̇, G , Kologlu, N , Çokuğraş, H . "Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential biomarkers of acute exacerbation in children with non-cystic fibrosis bronchiectasis" . Pamukkale Tıp Dergisi 13 (2020 ): 759-766 <https://dergipark.org.tr/tr/pub/patd/issue/55097/752594>
Chicago Kılınç, A , Ali̇shbayli̇, G , Kologlu, N , Çokuğraş, H . "Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential biomarkers of acute exacerbation in children with non-cystic fibrosis bronchiectasis". Pamukkale Tıp Dergisi 13 (2020 ): 759-766
RIS TY - JOUR T1 - Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential biomarkers of acute exacerbation in children with non-cystic fibrosis bronchiectasis AU - Ayse Ayzıt Kılınç , Gulizar Ali̇shbayli̇ , Nursena Kologlu , Haluk Çokuğraş Y1 - 2020 PY - 2020 N1 - doi: 10.31362/patd.752594 DO - 10.31362/patd.752594 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 759 EP - 766 VL - 13 IS - 3 SN - -1308-0865 M3 - doi: 10.31362/patd.752594 UR - https://doi.org/10.31362/patd.752594 Y2 - 2020 ER -
EndNote %0 Pamukkale Tıp Dergisi Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential biomarkers of acute exacerbation in children with non-cystic fibrosis bronchiectasis %A Ayse Ayzıt Kılınç , Gulizar Ali̇shbayli̇ , Nursena Kologlu , Haluk Çokuğraş %T Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential biomarkers of acute exacerbation in children with non-cystic fibrosis bronchiectasis %D 2020 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 13 %N 3 %R doi: 10.31362/patd.752594 %U 10.31362/patd.752594
ISNAD Kılınç, Ayse Ayzıt , Ali̇shbayli̇, Gulizar , Kologlu, Nursena , Çokuğraş, Haluk . "Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential biomarkers of acute exacerbation in children with non-cystic fibrosis bronchiectasis". Pamukkale Tıp Dergisi 13 / 3 (Eylül 2020): 759-766 . https://doi.org/10.31362/patd.752594
AMA Kılınç A , Ali̇shbayli̇ G , Kologlu N , Çokuğraş H . Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential biomarkers of acute exacerbation in children with non-cystic fibrosis bronchiectasis. Pamukkale Tıp Dergisi. 2020; 13(3): 759-766.
Vancouver Kılınç A , Ali̇shbayli̇ G , Kologlu N , Çokuğraş H . Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential biomarkers of acute exacerbation in children with non-cystic fibrosis bronchiectasis. Pamukkale Tıp Dergisi. 2020; 13(3): 759-766.