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COVID-19 hastalığı böbrek taşı olan hastaları nasıl etkiledi?

Yıl 2022, Cilt 15, Sayı 3, 611 - 618, 01.07.2022
https://doi.org/10.31362/patd.1117026

Öz

Amaç: Böbrek taşı varlığı ile COVID-19 hastalığı arasındaki ilişkinin değerlendirilmesi
Gereç ve yöntem: COVID-19 tanısı ile 15 Kasım-31 Aralık 2020 tarihleri arasında 2. ve 3. basamak 2 farklı merkezde ayaktan, servis ve/veya yoğun bakımda tedavi uygulanan hastalar retrospektif olarak tarandı. Öncelikle hastalar böbrek taşı varlığına göre alt gruplara ayrıldı ve daha sonra böbrek taşı olan olgular, ayaktan tedavi gören hastalar Grup 1, serviste yatarak tedavi gören hastalar Grup 2 ve yoğun bakımda tedavi ihtiyacı doğan olgular ise Grup 3 olarak kategorize edildi.
Bulgular: Çalışmaya toplam 1335 COVID-19 hastası dahil edildi. Ayaktan tedavi edilen 450 hastanın 31'inde (%6,9), serviste yatan 460 hastanın 41'inde (%8,9) ve yoğun bakımda yatan 425 hastanın 60'ında (%14,1) böbrek taşı mevcuttu. Grup 1'de, böbrek taşı olan hastalarda COVID-19 tedavi süresi böbrek taşı olmayan hastalara göre anlamlı olarak daha uzundu (8,1±1,7 ve 6,8±2,2 gün, p=0,01). Grup 2 ve Grup 3'te ortalama hastanede kalış süresi böbrek taşı olan hastalarda böbrek taşı olmayanlara göre anlamlı olarak daha uzundu (sırasıyla 9,1±3,7 ve 6,2±2,1 gün, p=0,007; 19,1±8,1 ve 11,3±6,2 gün, p=0,001).
Sonuç: Böbrek taşı olanlarda COVID-19 tedavi süresinin daha fazla ve COVID-19 enfeksiyonunun daha şiddetli olduğu saptandı.

Kaynakça

  • 1. Erensoy, S., SARS-CoV-2 and Microbiological Diagnostic Dynamics in COVID-19 Pandemic. Mikrobiyoloji bulteni, 2020. 54(3): p. 497-509.
  • 2. Krishnan, A., et al., A narrative review of coronavirus disease 2019 (COVID-19): clinical, epidemiological characteristics, and systemic manifestations. Intern Emerg Med, 2021: p. 1-16.
  • 3. Mehta, P., et al., COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet, 2020. 395(10229): p. 1033-1034.
  • 4. Yoshikawa, T., et al., Severe acute respiratory syndrome (SARS) coronavirus-induced lung epithelial cytokines exacerbate SARS pathogenesis by modulating intrinsic functions of monocyte-derived macrophages and dendritic cells. J Virol, 2009. 83(7): p. 3039-48.
  • 5. Yuki, K., M. Fujiogi, and S. Koutsogiannaki, COVID-19 pathophysiology: A review. Clin Immunol, 2020. 215: p. 108427.
  • 6. Pirola, C.J. and S. Sookoian, Age but not sex may explain the negative effect of arterial hypertension and diabetes on COVID-19 prognosis. J Infect, 2020. 81(4): p. 647-679.
  • 7. Ragab, D., et al., The COVID-19 Cytokine Storm; What We Know So Far. Front Immunol, 2020. 11: p. 1446.
  • 8. López-Lluch, G., et al., Mitochondrial responsibility in ageing process: innocent, suspect or guilty. Biogerontology, 2015. 16(5): p. 599-620.
  • 9. Moreno Fernández-Ayala, D.J., P. Navas, and G. López-Lluch, Age-related mitochondrial dysfunction as a key factor in COVID-19 disease. Exp Gerontol, 2020. 142: p. 111147.
  • 10. Sorokin, I., et al., Epidemiology of stone disease across the world. World Journal of Urology, 2017. 35(9): p. 1301-1320.
  • 11. Scales, C.D., Jr., et al., Prevalence of kidney stones in the United States. Eur Urol, 2012. 62(1): p. 160-5.
  • 12. Patel, M., et al., Oxalate induces mitochondrial dysfunction and disrupts redox homeostasis in a human monocyte derived cell line. Redox Biol, 2018. 15: p. 207-215.
  • 13. de Lucena, T.M.C., et al., Mechanism of inflammatory response in associated comorbidities in COVID-19. Diabetes Metab Syndr, 2020. 14(4): p. 597-600.
  • 14. Zhu, N., et al., A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med, 2020. 382(8): p. 727-733.
  • 15. Darisipudi, M.N. and F. Knauf, An update on the role of the inflammasomes in the pathogenesis of kidney diseases. Pediatr Nephrol, 2016. 31(4): p. 535-44.
  • 16. Joosten, L.A.B., et al., Asymptomatic hyperuricaemia: a silent activator of the innate immune system. Nat Rev Rheumatol, 2020. 16(2): p. 75-86.
  • 17. Mulay, S.R., A. Evan, and H.J. Anders, Molecular mechanisms of crystal-related kidney inflammation and injury. Implications for cholesterol embolism, crystalline nephropathies and kidney stone disease. Nephrol Dial Transplant, 2014. 29(3): p. 507-14.
  • 18. Zeng, G., et al., Prevalence of kidney stones in China: an ultrasonography based cross-sectional study. BJU Int, 2017. 120(1): p. 109-116.
  • 19. Fu, Y., Y. Cheng, and Y. Wu, Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools. Virol Sin, 2020. 35(3): p. 266-271.
  • 20. Favalli, E.G., et al., COVID-19 infection and rheumatoid arthritis: Faraway, so close! Autoimmun Rev, 2020. 19(5): p. 102523.
  • 21. Ferri, C., et al., COVID-19 and rheumatic autoimmune systemic diseases: report of a large Italian patients series. Clin Rheumatol, 2020. 39(11): p. 3195-3204.
  • 22. Popa, I.V., et al., COVID-19 and Inflammatory Bowel Diseases: Risk Assessment, Shared Molecular Pathways, and Therapeutic Challenges. Gastroenterol Res Pract, 2020. 2020: p. 1918035.
  • 23. Doran, M.F., et al., Frequency of infection in patients with rheumatoid arthritis compared with controls: a population-based study. Arthritis Rheum, 2002. 46(9): p. 2287-93.
  • 24. Franklin, J., et al., Risk and predictors of infection leading to hospitalisation in a large primary-care-derived cohort of patients with inflammatory polyarthritis. Ann Rheum Dis, 2007. 66(3): p. 308-12.
  • 25. Fink, H.A., et al., Medical management to prevent recurrent nephrolithiasis in adults: a systematic review for an American College of Physicians Clinical Guideline. Ann Intern Med, 2013. 158(7): p. 535-43.
  • 26. Holmes, R.P. and D.G. Assimos, The impact of dietary oxalate on kidney stone formation. Urol Res, 2004. 32(5): p. 311-6.
  • 27. Nunnari, J. and A. Suomalainen, Mitochondria: in sickness and in health. Cell, 2012. 148(6): p. 1145-59.
  • 28. Khan, S.R., Reactive oxygen species, inflammation and calcium oxalate nephrolithiasis. Transl Androl Urol, 2014. 3(3): p. 256-276.
  • 29. Williams, J., et al., Monocyte Mitochondrial Function in Calcium Oxalate Stone Formers. Urology, 2016. 93: p. 224.e1-6.
  • 30. Meftahi, G.H., et al., The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of "inflame-aging". Inflamm Res, 2020. 69(9): p. 825-839.

How has the COVID-19 disease affected patients with kidney stones?

Yıl 2022, Cilt 15, Sayı 3, 611 - 618, 01.07.2022
https://doi.org/10.31362/patd.1117026

Öz

Purpose: To evaluate the relationship between the presence of kidney stones and COVID-19.
Materials and methods: Patients, who were treated for COVID-19 as outpatients as well as inpatients in the ward and/or ICU of two different secondary and tertiary care centers between July 15, 2020, and December 31, 2020, and aged ≥18 years were retrospectively evaluated. The patients were divided into two subgroups based on the presence of kidney stones, and then the patients with kidney stone were categorized into three groups: those who were treated in an outpatient setting (Group 1), those who were treated in the ward (Group 2), and those who were treated in the intensive care unit (Group 3).
Results: The total of 1,335 COVID-19 patients included in the study. Kidney stone was present in 31 (6.9%) of 450 outpatients, 41 (8.9%) of 460 inpatients treated in the ward, and 60 (14.1%) of 425 inpatients treated in the intensive care unit. In Group 1, the duration of COVID-19 treatment was significantly longer in patients with kidney stone than patients without kidney stone (8.1±1.7 vs. 6.8±2.2 days, p=0.01). In Group 2 and in Group 3, the mean hospitalization duration was significantly longer in patients with kidney stone than in those without kidney stone (9.1±3.7 vs. 6.2±2.1 days, p=0.007; 19.1±8.1 vs. 11.3±6.2 days, p=0.001, respectively).
Conclusion: The duration of COVID-19 treatment was longer and the COVID-19 infection was more severe in those with kidney stones.

Kaynakça

  • 1. Erensoy, S., SARS-CoV-2 and Microbiological Diagnostic Dynamics in COVID-19 Pandemic. Mikrobiyoloji bulteni, 2020. 54(3): p. 497-509.
  • 2. Krishnan, A., et al., A narrative review of coronavirus disease 2019 (COVID-19): clinical, epidemiological characteristics, and systemic manifestations. Intern Emerg Med, 2021: p. 1-16.
  • 3. Mehta, P., et al., COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet, 2020. 395(10229): p. 1033-1034.
  • 4. Yoshikawa, T., et al., Severe acute respiratory syndrome (SARS) coronavirus-induced lung epithelial cytokines exacerbate SARS pathogenesis by modulating intrinsic functions of monocyte-derived macrophages and dendritic cells. J Virol, 2009. 83(7): p. 3039-48.
  • 5. Yuki, K., M. Fujiogi, and S. Koutsogiannaki, COVID-19 pathophysiology: A review. Clin Immunol, 2020. 215: p. 108427.
  • 6. Pirola, C.J. and S. Sookoian, Age but not sex may explain the negative effect of arterial hypertension and diabetes on COVID-19 prognosis. J Infect, 2020. 81(4): p. 647-679.
  • 7. Ragab, D., et al., The COVID-19 Cytokine Storm; What We Know So Far. Front Immunol, 2020. 11: p. 1446.
  • 8. López-Lluch, G., et al., Mitochondrial responsibility in ageing process: innocent, suspect or guilty. Biogerontology, 2015. 16(5): p. 599-620.
  • 9. Moreno Fernández-Ayala, D.J., P. Navas, and G. López-Lluch, Age-related mitochondrial dysfunction as a key factor in COVID-19 disease. Exp Gerontol, 2020. 142: p. 111147.
  • 10. Sorokin, I., et al., Epidemiology of stone disease across the world. World Journal of Urology, 2017. 35(9): p. 1301-1320.
  • 11. Scales, C.D., Jr., et al., Prevalence of kidney stones in the United States. Eur Urol, 2012. 62(1): p. 160-5.
  • 12. Patel, M., et al., Oxalate induces mitochondrial dysfunction and disrupts redox homeostasis in a human monocyte derived cell line. Redox Biol, 2018. 15: p. 207-215.
  • 13. de Lucena, T.M.C., et al., Mechanism of inflammatory response in associated comorbidities in COVID-19. Diabetes Metab Syndr, 2020. 14(4): p. 597-600.
  • 14. Zhu, N., et al., A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med, 2020. 382(8): p. 727-733.
  • 15. Darisipudi, M.N. and F. Knauf, An update on the role of the inflammasomes in the pathogenesis of kidney diseases. Pediatr Nephrol, 2016. 31(4): p. 535-44.
  • 16. Joosten, L.A.B., et al., Asymptomatic hyperuricaemia: a silent activator of the innate immune system. Nat Rev Rheumatol, 2020. 16(2): p. 75-86.
  • 17. Mulay, S.R., A. Evan, and H.J. Anders, Molecular mechanisms of crystal-related kidney inflammation and injury. Implications for cholesterol embolism, crystalline nephropathies and kidney stone disease. Nephrol Dial Transplant, 2014. 29(3): p. 507-14.
  • 18. Zeng, G., et al., Prevalence of kidney stones in China: an ultrasonography based cross-sectional study. BJU Int, 2017. 120(1): p. 109-116.
  • 19. Fu, Y., Y. Cheng, and Y. Wu, Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools. Virol Sin, 2020. 35(3): p. 266-271.
  • 20. Favalli, E.G., et al., COVID-19 infection and rheumatoid arthritis: Faraway, so close! Autoimmun Rev, 2020. 19(5): p. 102523.
  • 21. Ferri, C., et al., COVID-19 and rheumatic autoimmune systemic diseases: report of a large Italian patients series. Clin Rheumatol, 2020. 39(11): p. 3195-3204.
  • 22. Popa, I.V., et al., COVID-19 and Inflammatory Bowel Diseases: Risk Assessment, Shared Molecular Pathways, and Therapeutic Challenges. Gastroenterol Res Pract, 2020. 2020: p. 1918035.
  • 23. Doran, M.F., et al., Frequency of infection in patients with rheumatoid arthritis compared with controls: a population-based study. Arthritis Rheum, 2002. 46(9): p. 2287-93.
  • 24. Franklin, J., et al., Risk and predictors of infection leading to hospitalisation in a large primary-care-derived cohort of patients with inflammatory polyarthritis. Ann Rheum Dis, 2007. 66(3): p. 308-12.
  • 25. Fink, H.A., et al., Medical management to prevent recurrent nephrolithiasis in adults: a systematic review for an American College of Physicians Clinical Guideline. Ann Intern Med, 2013. 158(7): p. 535-43.
  • 26. Holmes, R.P. and D.G. Assimos, The impact of dietary oxalate on kidney stone formation. Urol Res, 2004. 32(5): p. 311-6.
  • 27. Nunnari, J. and A. Suomalainen, Mitochondria: in sickness and in health. Cell, 2012. 148(6): p. 1145-59.
  • 28. Khan, S.R., Reactive oxygen species, inflammation and calcium oxalate nephrolithiasis. Transl Androl Urol, 2014. 3(3): p. 256-276.
  • 29. Williams, J., et al., Monocyte Mitochondrial Function in Calcium Oxalate Stone Formers. Urology, 2016. 93: p. 224.e1-6.
  • 30. Meftahi, G.H., et al., The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of "inflame-aging". Inflamm Res, 2020. 69(9): p. 825-839.

Ayrıntılar

Birincil Dil İngilizce
Konular Üroloji ve Nefroloji
Yayınlanma Tarihi Temmuz 2022
Bölüm Araştırma Makalesi
Yazarlar

Mesut Berkan DURAN> (Sorumlu Yazar)
PAMUKKALE UNIVERSITY, SCHOOL OF MEDICINE
0000-0002-8597-2081
Türkiye


Samet ŞENEL>
Ankara City Hospital
0000-0003-1909-170X
Türkiye


Tuğba İZCİ DURAN>
ONDOKUZ MAYIS UNIVERSITY, SCHOOL OF MEDICINE
0000-0003-4428-9873
Türkiye


Taha Numan YIKILMAZ>
Denizli Private Egekent Hospital
0000-0001-8410-2474
Türkiye


Serdar TOKSÖZ>
Hatay State Hospital
0000-0002-2649-1157
Türkiye

Yayımlanma Tarihi 1 Temmuz 2022
Kabul Tarihi 16 Haziran 2022
Yayınlandığı Sayı Yıl 2022, Cilt 15, Sayı 3

Kaynak Göster

Bibtex @araştırma makalesi { patd1117026, journal = {Pamukkale Tıp Dergisi}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2022}, volume = {15}, number = {3}, pages = {611 - 618}, doi = {10.31362/patd.1117026}, title = {How has the COVID-19 disease affected patients with kidney stones?}, key = {cite}, author = {Duran, Mesut Berkan and Şenel, Samet and İzci Duran, Tuğba and Yıkılmaz, Taha Numan and Toksöz, Serdar} }
APA Duran, M. B. , Şenel, S. , İzci Duran, T. , Yıkılmaz, T. N. & Toksöz, S. (2022). How has the COVID-19 disease affected patients with kidney stones? . Pamukkale Tıp Dergisi , 15 (3) , 611-618 . DOI: 10.31362/patd.1117026
MLA Duran, M. B. , Şenel, S. , İzci Duran, T. , Yıkılmaz, T. N. , Toksöz, S. "How has the COVID-19 disease affected patients with kidney stones?" . Pamukkale Tıp Dergisi 15 (2022 ): 611-618 <https://dergipark.org.tr/tr/pub/patd/issue/68347/1117026>
Chicago Duran, M. B. , Şenel, S. , İzci Duran, T. , Yıkılmaz, T. N. , Toksöz, S. "How has the COVID-19 disease affected patients with kidney stones?". Pamukkale Tıp Dergisi 15 (2022 ): 611-618
RIS TY - JOUR T1 - How has the COVID-19 disease affected patients with kidney stones? AU - Mesut Berkan Duran , Samet Şenel , Tuğba İzci Duran , Taha Numan Yıkılmaz , Serdar Toksöz Y1 - 2022 PY - 2022 N1 - doi: 10.31362/patd.1117026 DO - 10.31362/patd.1117026 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 611 EP - 618 VL - 15 IS - 3 SN - -1308-0865 M3 - doi: 10.31362/patd.1117026 UR - https://doi.org/10.31362/patd.1117026 Y2 - 2022 ER -
EndNote %0 Pamukkale Tıp Dergisi How has the COVID-19 disease affected patients with kidney stones? %A Mesut Berkan Duran , Samet Şenel , Tuğba İzci Duran , Taha Numan Yıkılmaz , Serdar Toksöz %T How has the COVID-19 disease affected patients with kidney stones? %D 2022 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 15 %N 3 %R doi: 10.31362/patd.1117026 %U 10.31362/patd.1117026
ISNAD Duran, Mesut Berkan , Şenel, Samet , İzci Duran, Tuğba , Yıkılmaz, Taha Numan , Toksöz, Serdar . "How has the COVID-19 disease affected patients with kidney stones?". Pamukkale Tıp Dergisi 15 / 3 (Temmuz 2022): 611-618 . https://doi.org/10.31362/patd.1117026
AMA Duran M. B. , Şenel S. , İzci Duran T. , Yıkılmaz T. N. , Toksöz S. How has the COVID-19 disease affected patients with kidney stones?. Pam Tıp Derg. 2022; 15(3): 611-618.
Vancouver Duran M. B. , Şenel S. , İzci Duran T. , Yıkılmaz T. N. , Toksöz S. How has the COVID-19 disease affected patients with kidney stones?. Pamukkale Tıp Dergisi. 2022; 15(3): 611-618.
IEEE M. B. Duran , S. Şenel , T. İzci Duran , T. N. Yıkılmaz ve S. Toksöz , "How has the COVID-19 disease affected patients with kidney stones?", Pamukkale Tıp Dergisi, c. 15, sayı. 3, ss. 611-618, Tem. 2022, doi:10.31362/patd.1117026
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