Relationship between cerebrovascular diseases and human leukocyte antigen subgroups

Yıl 2023, Cilt: 16 Sayı: 2, 318 - 324, 05.04.2023

Ufuk ÇINKIR Eylem TEKE Ergun METE

https://doi.org/10.31362/patd.1263788

Öz

Abstract
Purpose: Ischemic stroke is classified as large artery atherosclerosis, small vessel occlusion (lacunar infarcts),
ischemic stroke due to other identified causes, and cryptogenic. The human leukocyte antigen (HLA) complex
is a group of genes on chromosome six in humans responsible for encoding cell-surface proteins that regulate
the immune system. In this study, HLA’s roles in the pathophysiology of ischemic stroke, especially the lacunar
subgroup, are investigated, and their potential mechanisms are presented.
Materials and methods: This study consisted of 49 patients with ischemic stroke and 50 healthy participants.
HLA-A, HLA-B, HLA-C, HLA-DQB, and HLA-DRB subgroup genomes were assessed.
Results: A statistically significant difference in the presence of HLA-A, HLA-B, HLA-C, HLA-DQB, and HLADRB
subgroups was found between the control and patient groups. The presence of HLA-A*02, HLA-A*30,
HLA-B*08, HLA-B*15, and HLA-DQB*06 genomes was higher in the patient group than in the control group
(p≤0.05). Nevertheless, HLA-DQB*03 and HLA-DRB*11 genomes were found more in the control group than
the patient group (p≤0.05)
Conclusion: The results of this study pioneered in scrutinizing HLA alleles in small vascular disease (SVD).
HLA-A*01, HLA-A*30, HLA-B*08, HLA-B*15, HLA-DQB*06, HLA-DQB*03 and HLA-DRB*11 are associated with
HLA alleles of stroke patients with small vessel occlusion. We attempted to provide objective evidence for
whether HLA genomes could act as a discriminative factor between SVD patients and control groups, which
might hold considerable promise for future therapies.

Anahtar Kelimeler

Stroke, major histocompatibility complex, genome, small vessel disease, ischemia

Serebrovasküler hastalıklar ile insan lökosit antijen alt grupları arasındaki ilişki

Öz

Amaç: İskemik inme, büyük arter aterosklerozu, küçük damar tıkanıklığı (laküner enfarktlar), diğer tanımlanmış
nedenlere bağlı iskemik inme ve kriptojenik olarak sınıflandırılır. İnsan lökosit antijeni (HLA) kompleksi insanlarda
bağışıklık sistemini düzenleyen hücre yüzeyi proteinlerini kodlamaktan sorumlu, altıncı kromozom üzerinde yer
alan bir grup gendir. Bu araştırmada, HLA'nın iskemik inme patofizyolojisindeki özellikle laküner alt gruptaki
rollerinin araştırılması ve olası mekanizmaların aydınlatması amaçlanmıştır.
Gereç ve yöntem: Bu çalışma iskemik inmeli 49 hasta ve 50 sağlıklı katılımcıdan oluşmaktadır. HLA-A, HLA-B,
HLA-C, HLA-DQB ve HLA-DRB alt grup genomları değerlendirilmiştir.
Bulgular: Kontrol ve hasta gruplarında HLA-A, HLA-B, HLA-C, HLA-DQB ve HLA-DRB alt gruplarının varlığı
arasında istatistiksel olarak anlamlı fark bulunmuştur. HLA-A*02, HLA-A*30, HLA-B*08, HLA-B*15 ve HLADQB*
06 genomları hasta grubunda daha fazla bulunmuştur ve istatistiksel olarak anlamlı fark vardır (p≤0.05).
Bununla birlikte HLA-DQB*03 ve HLA-DRB*11 genomları kontrol grubunda daha fazla bulunmuştur (p≤0.05).
Sonuç: Bu araştırma, küçük damar hastalığında (KDH) HLA alellerini incelemede öncüdür. HLA-A*01,
HLA-A*30, HLA-B*08, HLA-B*15, HLA-DQB*06, HLA-DQB*03, HLA-DRB*11, inme hastalarının HLA alelleri
ile ilişkilidir. Küçük damar tıkanıklığı HLA genomlarının, KDH hastaları ve kontrol grupları arasında, gelecekteki
tedaviler için umut vaat edebilecek, ayırt edici bir faktör olarak hareket edip edemeyeceğine dair nesnel kanıtlar
sağlamaya çalıştık.

Anahtar Kelimeler

Strok, major doku uygunluk kompleksi, genom, küçük damar hastalığı, iskemi

Kaynakça

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