Araştırma Makalesi
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Son dönem böbrek yetmezlikli hastalarda vasküler kalsifikasyon, ateroskleroz ve inflamatuar belirteçler arasındaki ilişki ve vasküler kalsifikasyonun saptanmasında basit bir yöntem (direkt radyografi)

Yıl 2023, Cilt: 16 Sayı: 4, 558 - 569, 01.10.2023
https://doi.org/10.31362/patd.1274511

Öz

Amaç: Çalışmamızda diyaliz hastalarında malnütrisyonun; inflamasyon, ateroskleroz ve kalsifikasyonla olan ilişkisini araştırmayı planladık.
Gereç ve yöntem: Çalışmaya 140 kronik böbrek yetmezlikli (KBH) hasta ve 44 sağlıklı kontrol dahil edildi. Karotis intima-media kalınlığı (KİMK) doppler ultrasonografi ile ölçüldü. Kapak kalsifikasyonu ekokardiyografi ile değerlendirildi ve direkt grafi ile vasküler kalsifikasyon skorları (VKS) hesaplandı. Biyokimyasal parametreler rutin laboratuvar yöntemleri kullanılarak değerlendirildi. Malnütrisyonun değerlendirilmesinde subjektif global değerlendirme skorlaması (SGA) kullanıldı.
Bulgular: Çalışmada hemodiyaliz (HD) ve periton diyalizi (PD) hastaları arasında VKS açısından fark bulunmadı (HD için 1,84±2,35, PD için 1,77±1,64; p=0,83). KİMK, Osteopontin (OPN), interlökin-6 (IL-6) ve homosistein her iki diyaliz grubunda sağlıklı kontrollerle karşılaştırıldığında anlamlı olarak farklıydı. Ortalama karotis intima media kalınlığı (m-KİMK) HD hastalarında PD grubuna göre daha yüksekti. KİMK, vasküler kalsifikasyon ve SGA skorları yaş, diyaliz süresi ve kapak kalsifikasyon dereceleri ile pozitif, albümin seviyesi ile negatif korelasyon göstermekteydi. SGA skorları ile yüksek duyarlı C-reaktif protein (hs-CRP) seviyeleri arasında da pozitif yönde korelasyon kaydedildi. Çoklu regresyon analizinde m-KİMK bağımsız olarak yaş, VCS ve albümin seviyesi ile ilişkili bulunurken; VCS'nun bağımsız olarak sadece albümin seviyesi ile ilişkili olduğu bulundu.
Sonuç: Çalışmamızda diyaliz hastalarında kardiyovasküler mortalite ve morbiditenin önemli bir göstergesi olan vasküler-valvüler kalsifikasyonla malnütrisyonun önemli ilişkisinin olduğunu gördük. Vasküler kalsifikasyonu olan hastalarda valvüler kalsifikasyon belirgindi. Bu grup hastada malnütrisyon da belirgindi.

Destekleyen Kurum

Gazi Üniversitesi Bilimsel araştırma projeleri birimi

Kaynakça

  • 1. London GM, Guerin AP, Marchais SJ, Metivier F, Pannier B, Adda H. Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrol Dial Transplant 2003;18:1731-1740. https://doi.org/10.1093/ndt/gfg414
  • 2. Jono S, Shioi A, Ikari Y, Nishizawa Y. Vascular calcification in chronic kidney disease. J Bone Miner Metab 2006;24:176-181. https://doi.org/10.1007/s00774-005-0668-6
  • 3. Mehrotra R. Emerging role for fetuin-A as contributor to morbidity and mortality in chronic kidney disease. Kidney Int 2007;72:137-140. https://doi.org/10.1038/sj.ki.5002355
  • 4. Fabris F, Zanocchi M, Bo M, et al. Carotid plaque, aging, and risk factors. A study of 457 subjects. Stroke 1994;25:1133-1140. https://doi.org/10.1161/01.STR.25.6.1133
  • 5. Zoungas S, Ristevski S, Lightfoot P, et al. Carotid artery intima-medial thickness is increased in chronic renal failure. Clin Exp Pharmacol Physiol 2000;27:639-641. https://doi.org/10.1046/j.1440-1681.2000.03301
  • 6. Nishizawa Y, Shoji T, Maekawa K, et al. Intima-media thickness of carotid artery predicts cardiovascular mortality in hemodialysis patients. Am J Kidney Dis 2003;41:76-79 https://doi.org/10.1053/ajkd.2003.50090
  • 7. Stenvinkel P, Heimbürger O, Lindholm B, Kaysen GA, Bergström J. Are there two types of malnutrition in chronic renal failure? Evidence for relationships between malnutrition, inflammation and atherosclerosis (MIA syndrome). Nephrol Dial Transplant 2000;15:953-960. https://doi.org/10.1093/ndt/15.7.953
  • 8. Kalantar Zadeh K, Stenvinkel P, Pillon L, Kopple JD. Inflammation and nutrition in renal insufficiency. Adv Ren Replace Ther 2003;10:155-169. https://doi.org/10.1053/j.arrt.2003.08.008
  • 9. Kalantar Zadeh K. Recent advances in understanding the malnutrition-inflammation-cachexia syndrome in chronic kidney disease patients: What is next? Semin Dial 2005;18:365-369. https://doi.org/10.1111/j.1525-139x.2005.00074.x
  • 10. Pecoits Filho R, Lindholm B, Stenvinkel P. The malnutrition, inflammation, and atherosclerosis (MIA) syndrome- the heart of the matter. Nephrol Dial Transplant 2002;17:28-31 https://doi.org/10.1093/ndt/17.suppl_11.28
  • 11. Himmelfarb J, Stenvinkel P, Ikizler TA, Hakim RM. The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia. Kıdney Int 2002;62:1524-1538. https://doi.org/10.1046/j.1523-1755.2002.00600.x
  • 12. Stenvinkel P. The role of inflammation in the anaemia of end-stage renal disease. Nephrology Dial Transplant 2001;16:36-40. https://doi.org/10.1093/ndt/16.suppl_7.36
  • 13. Nomura S, Wills AJ, Edwards DR, Heath JK, Hogan BL. Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization. J Cell Biol 1988;106:441-450. https://doi.org/10.1083/jcb.106.2.441
  • 14. Steitz SA, Speer MY, McKee MD, et al. Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification. Am J Pathol 2002;161:2035-2046. https://doi.org/10.1016/S0002-9440(10)64482-3
  • 15. Ahmed S, O’Neill KD, Hood AF, Evan AP, Moe SM. Calciphylaxis is associated with hyperphosphatemia and increased osteopontin expression by vascular smooth muscle cells. Am J Kidney Dis 2001;37:1267-1276. https://doi.org/10.1053/ajkd.2001.24533
  • 16. Yeun JY, Levine RA, Mantadilok V, Kaysen GA. C-reactive protein predicts all-cause and cardiovascular mortality in hemodialysis patients. Am J Kidney Dis 2000;35:469-476. https://doi.org/10.1016/S0272-6386(00)70200-9
  • 17. Scatena M, Liaw L, Giacchelli CM. Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease. Arterioscler Thromb Vasc Biol 2007;27:2302-2309. https://doi.org/10.1161/ATVBAHA.107.144824
  • 18. Zimmermann J, Herrlinger S, Pruy A, Metzger T, Wanner C. Inflammation enhances cardiovascular risk and mortality in hemodialysis patients. Kıdney Int 1999;55:648-658. https://doi.org/10.1046/j.1523-1755.1999.00273.x
  • 19. Pecoits Filho R, Barany P, Lindholm B, Heimbürger O, Stenvinkel P. Interleukin-6 is an independent predictor of mortality in patients starting dialysis treatment. Nephrol Dial Transplant 2002;17:1684-1688. https://doi.org/10.1093/ndt/17.9.1684
  • 20. Rao M, Guo D, Perianayagam MC, et al. Plasma interleukin-6 predicts cardiovascular mortality in hemodialysis patients. Am J Kidney Dis 2005;45:324-333. https://doi.org/10.1053/j.ajkd.2004.09.018
  • 21. Cohen BD, Patel H, Kornhauser RS. Alternate reasons for atherogenesis in uremia. Proc Clin Dial Transplant Forum 1977;7:178-180.
  • 22. Adragao T, Pires A, Lucas C, et al. A simple vascular calcification score predicts cardiovascular risk in haemodialysis patients. Nephrol Dial Transplant 2004;19:1480-1488. https://doi.org/10.1093/ndt/gfh217
  • 23. Mallamaci F, Zoccali C, Tripepi G, et al. Hyperhomocystenemia predicts cardiovascular outcomes in hemodiaysis patients. Kidney Int 2002;61:609-614. https://doi.org/10.1046/j.1523-1755.2002.00144.x
  • 24. Moustapha A, Naso A, Nahlawi M, et al. Prospective study of hyperhomocysteinemia as an adverse cardiovascular risk factor in end-stage renal disease. Circulation 1998;97:138-141. https://doi.org/10.1161/01.CIR.97.2.138
  • 25. Nair AP, Nemirovsky D, Kim M, et al. Elevated homocysteine levels in patients with end-stage renal disease. Mt Sinai J Med 2005;72:365-373.
  • 26. Sahn DJ, De Maria A, Kisslo J, Weyman A. Recommendations regarding quantification in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation 1978;58:1072-1083. https://doi.org/10.1161/01.cir.58.6.1072
  • 27. Schiller NB, Shah PM, Crawford M, et al. Recommendations for quantification of the left ventricle by two-dimensional echocardiography: American Society of Echocardiographic Committee on Standards, Subcommittee on Quantification of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr 1989;2:358-367. https://doi.org/10.1016/s0894-7317(89)80014-8
  • 28. Pomerance A. Pathogenesis of aortic stenosis and its relation to age. Br Heart J 1972;34:569-574. https://doi.org/10.1136/hrt.34.6.569
  • 29. Kalantar Zadeh K, Kleiner M, Dunne E, Lee GH, Luft FC. A modified quantitative subjective global assessment of nutrition for dialysis patients. Nephrol Dial Transplant 1999;14:1732-1738. https://doi.org/10.1093/ndt/14.7.1732
  • 30. Kato A, Takita T, Maruyama Y, Kumagai H, Hishida A. Impact of carotid atherosclerosis on long-term mortality in chronic haemodialysis patients. Kidney Int 2003;64:1472-1479. https://doi.org/10.1046/j.1523-1755.2003.00205.x
  • 31. Hojs R. Carotid intima-media thickness and plaques in haemodialysis patients. Artif Organs 2000;24:691-695. https://doi.org/10.1046/j.1525-1594.2000.06466.x
  • 32. Rroji M, Spahia N, Seferi S, Barbullushi M, Spasovski G. Influence of residual renal function in carotid modeling as a marker of early atherosclerosis in dialysis patients. Ther Apher Dial 2017;21:451-458. https://doi.org/10.1111/1744-9987.12548
  • 33. Shoji T, Nishizawa Y. Chronic kidney disease as a metabolic syndrome with malnutrition-need for strict control of risk factors. Int Med 2005;44:179-187. https://doi.org/10.2169/internalmedicine.44.179
  • 34. Furuki K, Adachi H, Enomoto M, et al. Plasma level of asymmetric dimethylargine (ADMA) as a predictor of carotid intima-media thickness progression: six-year prospective study using carotid ultrasonography. Hypertens Res 2008;31:1185-1189. https://doi.org/10.1291/hypres.31.1185
  • 35. Preston E, Ellis MR, Kulinskaya E, Davies AH, Brown EA. Association between carotid artery intima-media thickness and cardiovascular risk factors in CKD. Am J Kidney Dis 2005;46:856-862. https://doi.org/10.1053/j.ajkd.2005.07.048
  • 36. Akdag I, Yilmaz Y, Kahvecioglu S, et al. Clinical value of the malnutrition-inflammation-atherosclerosis syndrome for long-term prediction of cardiovascular mortality in patients with end-stage renal disease: a 5-year prospective study. Nephron Clin Pract 2008;108:99-105. https://doi.org/10.1159/000113526
  • 37. Ishimura E, Okuno S, Taniwaki H, et al. Different risk factors for vascular calcification in end-stage renal disease between diabetics and nondiabetics: the respective importance of glycemic and phosphate control. Kidney Blood Press Res 2008;31:10-15. https://doi.org/10.1159/000112542
  • 38. Ix JH, Chertow GM, Shlipak MG, Brandenburg VM, Ketteler M, Whooley MA. Fetuin-A and kidney function in persons with coronary artery disease--data from the heart and soul study. Nephrol Dial Transplant 2006;21:2144-2151. https://doi.org/10.1093/ndt/gfl204
  • 39. Zoccali C, Mallamaci F, Tripepi G. Inflammatory proteins as predictors of cardiovascular disease in patients with end-stage renal disease. Nephrol Dial Transplant 2004;19:67-72. https://doi.org/10.1093/ndt/gfh1059
  • 40. Honda H, Qureshi AR, Heimburger O, et al. Serum albumin, C-reactive protein, interleukin 6, and fetuin a as predictors of manutrition, cardiovascular disease, and mortality in patients with ESRD. Am J Kidney Dis 2006;47:139-148. https://doi.org/10.1053/j.ajkd.2005.09.014
  • 41. Stenvinkel P, Heimburger O, Paultre P, et al. Strong association between malnutrition, inflammation and atherosclerosis in chronic renal failure. Kidney Int 1999;55:1899-1911. https://doi.org/10.1046/j.1523-1755.1999.00422.x
  • 42. Stenvinkel P, Alvestrand A. Inflammation in end-stage renal disease: sources, consequences, and therapy. Semin Dial 2002;15:329-337. https://doi.org/10.1046/j.1525-139x.2002.00083.x
  • 43. Ahmed S, O’Neill KD, Hood AF, Evan AP, Moe SM. Calciphylaxis is associated with hyperphosphatemia and increased osteopontin expression by vascular smooth muscle cells. Am J Kidney Dis 2001;37:1267-1276. https://doi.org/10.1053/ajkd.2001.24533
  • 44. Kurata M, Okura T, Watanabe S, Fukuoka T, Higaki J. Osteopontin and carotid atherosclerosis in patients with essential hypertension. Clin Sci (Lond) 2006;111:319-324. https://doi.org/10.1042/CS20060074
  • 45. Nitta K, Ishizuka T, Horita S, et al. Soluble osteopontin and vascular calcification in hemodialysis patients. Nephron 2001;89:455-458. https://doi.org/10.1159/000046119
  • 46. Mallat SG, Aoun M. Hyperhomocysteinemia and its role in chronic renal failure. Saudi J Kidney Dis Transpl 2002;13:336-343.
  • 47. Babaei M, Dashti N, Lamei N, et al. Evaluation of plasma concentrations of homocysteine, IL-6, TNF-alpha, hs-CRP, and total antioxidant capacity in End-stage renal failure. Acta Med Iran 2014;52:893-898. 48. Brattström L, Wilcken DE. Homocysteine and cardiovascular disease: cause or effect? Am J Clin Nutr 2000;72:315-323. https://doi.org/10.1093/ajcn/72.2.315
  • 49. Krasniak A, Drozdz M, Pasowicz M, et al. Factors involved in vascular calcification and atherosclerosis in maintenance haemodialysis patients. Nephrol Dial Transplant 2007;22:515-521. https://doi.org/10.1093/ndt/gfl564

Association between vascular calcification, atherosclerosis and inflammatory markers in end-stage renal disease patient and simple method for detecting vascular calcification (direct radiography)

Yıl 2023, Cilt: 16 Sayı: 4, 558 - 569, 01.10.2023
https://doi.org/10.31362/patd.1274511

Öz

Purpose: In our study, we planned to investigate the relationship of malnutrition with inflammation, atherosclerosis and calcification in dialysis patients.
Materials and methods: 140 Chronic kidney disease (CKD) patients and 44 healthy controls were included in the study. Carotid artery intima-media thickness (CIMT) was measured by doppler ultrasonography. Valvular calcification was assessed by echocardiography and vascular calcification scores (VCS) were done based on the radiograms. Biochemical parameters were assessed using routine laboratory methods. Subjective global assessment (SGA) was used to evaluate malnutrition.
Results: In the study, VCS showed no differences between hemodialysis (HD) and peritoneal dialysis (PD) patients (1.84±2.35 for HD, 1.77±1.64 for PD; p=0.83). CIMT, Osteopontin (OPN), interleukin-6 (IL-6) and homocysteine were significantly different in both dialysis groups compared to healthy controls. The Mean carotid intima-media thickness (m-CIMT) was higher in HD patients compared to PD group. CIMT, vascular calcification and SGA scores showed positive correlation with age, dialysis duration and valvular calcification grades, and negative correlation with albumin levels. A positive correlation between SGA scores and high-sensitive C-reactive protein (hs-CRP) levels was also noted. On multiple regression analysis, m-CIMT was independently associated with age, VCS and albumin levels. VCS was found to be independently associated with only albumin levels.
Conclusion: Vascular and valvular calcification, an indicator of cardiovascular mortality and morbidity in dialysis patients, was found to be significantly associated with malnutrition. We found higher rates of valvular calcification in patients with vascular calcification. Malnutrition was more prominent in these patients.

Kaynakça

  • 1. London GM, Guerin AP, Marchais SJ, Metivier F, Pannier B, Adda H. Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrol Dial Transplant 2003;18:1731-1740. https://doi.org/10.1093/ndt/gfg414
  • 2. Jono S, Shioi A, Ikari Y, Nishizawa Y. Vascular calcification in chronic kidney disease. J Bone Miner Metab 2006;24:176-181. https://doi.org/10.1007/s00774-005-0668-6
  • 3. Mehrotra R. Emerging role for fetuin-A as contributor to morbidity and mortality in chronic kidney disease. Kidney Int 2007;72:137-140. https://doi.org/10.1038/sj.ki.5002355
  • 4. Fabris F, Zanocchi M, Bo M, et al. Carotid plaque, aging, and risk factors. A study of 457 subjects. Stroke 1994;25:1133-1140. https://doi.org/10.1161/01.STR.25.6.1133
  • 5. Zoungas S, Ristevski S, Lightfoot P, et al. Carotid artery intima-medial thickness is increased in chronic renal failure. Clin Exp Pharmacol Physiol 2000;27:639-641. https://doi.org/10.1046/j.1440-1681.2000.03301
  • 6. Nishizawa Y, Shoji T, Maekawa K, et al. Intima-media thickness of carotid artery predicts cardiovascular mortality in hemodialysis patients. Am J Kidney Dis 2003;41:76-79 https://doi.org/10.1053/ajkd.2003.50090
  • 7. Stenvinkel P, Heimbürger O, Lindholm B, Kaysen GA, Bergström J. Are there two types of malnutrition in chronic renal failure? Evidence for relationships between malnutrition, inflammation and atherosclerosis (MIA syndrome). Nephrol Dial Transplant 2000;15:953-960. https://doi.org/10.1093/ndt/15.7.953
  • 8. Kalantar Zadeh K, Stenvinkel P, Pillon L, Kopple JD. Inflammation and nutrition in renal insufficiency. Adv Ren Replace Ther 2003;10:155-169. https://doi.org/10.1053/j.arrt.2003.08.008
  • 9. Kalantar Zadeh K. Recent advances in understanding the malnutrition-inflammation-cachexia syndrome in chronic kidney disease patients: What is next? Semin Dial 2005;18:365-369. https://doi.org/10.1111/j.1525-139x.2005.00074.x
  • 10. Pecoits Filho R, Lindholm B, Stenvinkel P. The malnutrition, inflammation, and atherosclerosis (MIA) syndrome- the heart of the matter. Nephrol Dial Transplant 2002;17:28-31 https://doi.org/10.1093/ndt/17.suppl_11.28
  • 11. Himmelfarb J, Stenvinkel P, Ikizler TA, Hakim RM. The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia. Kıdney Int 2002;62:1524-1538. https://doi.org/10.1046/j.1523-1755.2002.00600.x
  • 12. Stenvinkel P. The role of inflammation in the anaemia of end-stage renal disease. Nephrology Dial Transplant 2001;16:36-40. https://doi.org/10.1093/ndt/16.suppl_7.36
  • 13. Nomura S, Wills AJ, Edwards DR, Heath JK, Hogan BL. Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization. J Cell Biol 1988;106:441-450. https://doi.org/10.1083/jcb.106.2.441
  • 14. Steitz SA, Speer MY, McKee MD, et al. Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification. Am J Pathol 2002;161:2035-2046. https://doi.org/10.1016/S0002-9440(10)64482-3
  • 15. Ahmed S, O’Neill KD, Hood AF, Evan AP, Moe SM. Calciphylaxis is associated with hyperphosphatemia and increased osteopontin expression by vascular smooth muscle cells. Am J Kidney Dis 2001;37:1267-1276. https://doi.org/10.1053/ajkd.2001.24533
  • 16. Yeun JY, Levine RA, Mantadilok V, Kaysen GA. C-reactive protein predicts all-cause and cardiovascular mortality in hemodialysis patients. Am J Kidney Dis 2000;35:469-476. https://doi.org/10.1016/S0272-6386(00)70200-9
  • 17. Scatena M, Liaw L, Giacchelli CM. Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease. Arterioscler Thromb Vasc Biol 2007;27:2302-2309. https://doi.org/10.1161/ATVBAHA.107.144824
  • 18. Zimmermann J, Herrlinger S, Pruy A, Metzger T, Wanner C. Inflammation enhances cardiovascular risk and mortality in hemodialysis patients. Kıdney Int 1999;55:648-658. https://doi.org/10.1046/j.1523-1755.1999.00273.x
  • 19. Pecoits Filho R, Barany P, Lindholm B, Heimbürger O, Stenvinkel P. Interleukin-6 is an independent predictor of mortality in patients starting dialysis treatment. Nephrol Dial Transplant 2002;17:1684-1688. https://doi.org/10.1093/ndt/17.9.1684
  • 20. Rao M, Guo D, Perianayagam MC, et al. Plasma interleukin-6 predicts cardiovascular mortality in hemodialysis patients. Am J Kidney Dis 2005;45:324-333. https://doi.org/10.1053/j.ajkd.2004.09.018
  • 21. Cohen BD, Patel H, Kornhauser RS. Alternate reasons for atherogenesis in uremia. Proc Clin Dial Transplant Forum 1977;7:178-180.
  • 22. Adragao T, Pires A, Lucas C, et al. A simple vascular calcification score predicts cardiovascular risk in haemodialysis patients. Nephrol Dial Transplant 2004;19:1480-1488. https://doi.org/10.1093/ndt/gfh217
  • 23. Mallamaci F, Zoccali C, Tripepi G, et al. Hyperhomocystenemia predicts cardiovascular outcomes in hemodiaysis patients. Kidney Int 2002;61:609-614. https://doi.org/10.1046/j.1523-1755.2002.00144.x
  • 24. Moustapha A, Naso A, Nahlawi M, et al. Prospective study of hyperhomocysteinemia as an adverse cardiovascular risk factor in end-stage renal disease. Circulation 1998;97:138-141. https://doi.org/10.1161/01.CIR.97.2.138
  • 25. Nair AP, Nemirovsky D, Kim M, et al. Elevated homocysteine levels in patients with end-stage renal disease. Mt Sinai J Med 2005;72:365-373.
  • 26. Sahn DJ, De Maria A, Kisslo J, Weyman A. Recommendations regarding quantification in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation 1978;58:1072-1083. https://doi.org/10.1161/01.cir.58.6.1072
  • 27. Schiller NB, Shah PM, Crawford M, et al. Recommendations for quantification of the left ventricle by two-dimensional echocardiography: American Society of Echocardiographic Committee on Standards, Subcommittee on Quantification of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr 1989;2:358-367. https://doi.org/10.1016/s0894-7317(89)80014-8
  • 28. Pomerance A. Pathogenesis of aortic stenosis and its relation to age. Br Heart J 1972;34:569-574. https://doi.org/10.1136/hrt.34.6.569
  • 29. Kalantar Zadeh K, Kleiner M, Dunne E, Lee GH, Luft FC. A modified quantitative subjective global assessment of nutrition for dialysis patients. Nephrol Dial Transplant 1999;14:1732-1738. https://doi.org/10.1093/ndt/14.7.1732
  • 30. Kato A, Takita T, Maruyama Y, Kumagai H, Hishida A. Impact of carotid atherosclerosis on long-term mortality in chronic haemodialysis patients. Kidney Int 2003;64:1472-1479. https://doi.org/10.1046/j.1523-1755.2003.00205.x
  • 31. Hojs R. Carotid intima-media thickness and plaques in haemodialysis patients. Artif Organs 2000;24:691-695. https://doi.org/10.1046/j.1525-1594.2000.06466.x
  • 32. Rroji M, Spahia N, Seferi S, Barbullushi M, Spasovski G. Influence of residual renal function in carotid modeling as a marker of early atherosclerosis in dialysis patients. Ther Apher Dial 2017;21:451-458. https://doi.org/10.1111/1744-9987.12548
  • 33. Shoji T, Nishizawa Y. Chronic kidney disease as a metabolic syndrome with malnutrition-need for strict control of risk factors. Int Med 2005;44:179-187. https://doi.org/10.2169/internalmedicine.44.179
  • 34. Furuki K, Adachi H, Enomoto M, et al. Plasma level of asymmetric dimethylargine (ADMA) as a predictor of carotid intima-media thickness progression: six-year prospective study using carotid ultrasonography. Hypertens Res 2008;31:1185-1189. https://doi.org/10.1291/hypres.31.1185
  • 35. Preston E, Ellis MR, Kulinskaya E, Davies AH, Brown EA. Association between carotid artery intima-media thickness and cardiovascular risk factors in CKD. Am J Kidney Dis 2005;46:856-862. https://doi.org/10.1053/j.ajkd.2005.07.048
  • 36. Akdag I, Yilmaz Y, Kahvecioglu S, et al. Clinical value of the malnutrition-inflammation-atherosclerosis syndrome for long-term prediction of cardiovascular mortality in patients with end-stage renal disease: a 5-year prospective study. Nephron Clin Pract 2008;108:99-105. https://doi.org/10.1159/000113526
  • 37. Ishimura E, Okuno S, Taniwaki H, et al. Different risk factors for vascular calcification in end-stage renal disease between diabetics and nondiabetics: the respective importance of glycemic and phosphate control. Kidney Blood Press Res 2008;31:10-15. https://doi.org/10.1159/000112542
  • 38. Ix JH, Chertow GM, Shlipak MG, Brandenburg VM, Ketteler M, Whooley MA. Fetuin-A and kidney function in persons with coronary artery disease--data from the heart and soul study. Nephrol Dial Transplant 2006;21:2144-2151. https://doi.org/10.1093/ndt/gfl204
  • 39. Zoccali C, Mallamaci F, Tripepi G. Inflammatory proteins as predictors of cardiovascular disease in patients with end-stage renal disease. Nephrol Dial Transplant 2004;19:67-72. https://doi.org/10.1093/ndt/gfh1059
  • 40. Honda H, Qureshi AR, Heimburger O, et al. Serum albumin, C-reactive protein, interleukin 6, and fetuin a as predictors of manutrition, cardiovascular disease, and mortality in patients with ESRD. Am J Kidney Dis 2006;47:139-148. https://doi.org/10.1053/j.ajkd.2005.09.014
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Ayrıntılar

Birincil Dil İngilizce
Konular Üroloji
Bölüm Araştırma Makalesi
Yazarlar

Rüya MUTLUAY
Tıp fakültesi
0000-0002-7159-0082
Türkiye


Çiğdem MENGÜŞ
Department of Nephrology, Adıyaman Training and Research Hospital, Adıyaman
0000-0002-4355-9731
Türkiye


Neslihan TEZCAN
Department of Nephrology, Kutahya Evliya Celebi Training and Research Hospital, Kütahya
0000-0002-6525-6088
Türkiye


Emel ISIKTAS SAYILAR
Department of Nephrology, Etlik City Hospital, Ankara
0000-0002-8824-6560
Türkiye


Ulver DERICI
Department of Nephrology, Gazi University Faculty of Medicine, Ankara
0000-0002-9741-6779
Türkiye


Ceyla KONCA DEĞERTEKİN
Department of Endocrinology, Ufuk University Faculty of Medicine, Ankara
0000-0003-0299-6596
Türkiye


Serap GÜLTEKİN
Department of Radiology, Gazi University Faculty of Medicine, Ankara
0000-0001-6349-3998
Türkiye


Sevim GÖNEN
Department of Pediatrics, Gazi University Faculty of Medicine, Ankara
0000-0002-2059-6193
Türkiye


Gülten TAÇOY
Department of Cardiology, Gazi University Faculty of Medicine, Ankara
0000-0003-0898-3905
Türkiye

Proje Numarası This study was supported by Gazi University Scientific Research Projects Commission (SBE-01/2007-11)
Erken Görünüm Tarihi 25 Temmuz 2023
Yayımlanma Tarihi 1 Ekim 2023
Gönderilme Tarihi 31 Mart 2023
Kabul Tarihi 25 Temmuz 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 16 Sayı: 4

Kaynak Göster

APA
MUTLUAY, R., MENGÜŞ, Ç., TEZCAN, N., ISIKTAS SAYILAR, E., vd. (2023). Association between vascular calcification, atherosclerosis and inflammatory markers in end-stage renal disease patient and simple method for detecting vascular calcification (direct radiography). Pamukkale Medical Journal, 16(4), 558-569. https://doi.org/10.31362/patd.1274511
MLA
MUTLUAY, Rüya vd. “Association Between Vascular Calcification, Atherosclerosis and Inflammatory Markers in End-Stage Renal Disease Patient and Simple Method for Detecting Vascular Calcification (direct Radiography)”. Pamukkale Medical Journal, c. 16, sy. 4, 2023, ss. 558-69, doi:10.31362/patd.1274511.
Chicago
MUTLUAY, Rüya, Çiğdem MENGÜŞ, Neslihan TEZCAN, Emel ISIKTAS SAYILAR, Ulver DERICI, Ceyla KONCA DEĞERTEKİN, Serap GÜLTEKİN, Sevim GÖNEN, ve Gülten TAÇOY. “Association Between Vascular Calcification, Atherosclerosis and Inflammatory Markers in End-Stage Renal Disease Patient and Simple Method for Detecting Vascular Calcification (direct Radiography)”. Pamukkale Medical Journal 16, sy. 4 (Ekim 2023): 558-69. https://doi.org/10.31362/patd.1274511.
EndNote
MUTLUAY R, MENGÜŞ Ç, TEZCAN N, ISIKTAS SAYILAR E, DERICI U, KONCA DEĞERTEKİN C, GÜLTEKİN S, GÖNEN S, TAÇOY G (01 Ekim 2023) Association between vascular calcification, atherosclerosis and inflammatory markers in end-stage renal disease patient and simple method for detecting vascular calcification (direct radiography). Pamukkale Medical Journal 16 4 558–569.
ISNAD
MUTLUAY, Rüya vd. “Association Between Vascular Calcification, Atherosclerosis and Inflammatory Markers in End-Stage Renal Disease Patient and Simple Method for Detecting Vascular Calcification (direct Radiography)”. Pamukkale Medical Journal 16/4 (Ekim 2023), 558-569. https://doi.org/10.31362/patd.1274511.
AMA
MUTLUAY R, MENGÜŞ Ç, TEZCAN N, ISIKTAS SAYILAR E, DERICI U, KONCA DEĞERTEKİN C, GÜLTEKİN S, GÖNEN S, TAÇOY G. Association between vascular calcification, atherosclerosis and inflammatory markers in end-stage renal disease patient and simple method for detecting vascular calcification (direct radiography). Pam Tıp Derg. Ekim 2023;16(4):558-569. doi:10.31362/patd.1274511
Vancouver
MUTLUAY R, MENGÜŞ Ç, TEZCAN N, ISIKTAS SAYILAR E, DERICI U, KONCA DEĞERTEKİN C, GÜLTEKİN S, GÖNEN S, TAÇOY G. Association between vascular calcification, atherosclerosis and inflammatory markers in end-stage renal disease patient and simple method for detecting vascular calcification (direct radiography). Pam Tıp Derg. 2023;16(4):558-69.
IEEE
R. MUTLUAY, “Association between vascular calcification, atherosclerosis and inflammatory markers in end-stage renal disease patient and simple method for detecting vascular calcification (direct radiography)”, Pam Tıp Derg, c. 16, sy. 4, ss. 558–569, 2023, doi: 10.31362/patd.1274511.
JAMA
MUTLUAY R, MENGÜŞ Ç, TEZCAN N, ISIKTAS SAYILAR E, DERICI U, KONCA DEĞERTEKİN C, GÜLTEKİN S, GÖNEN S, TAÇOY G. Association between vascular calcification, atherosclerosis and inflammatory markers in end-stage renal disease patient and simple method for detecting vascular calcification (direct radiography). Pam Tıp Derg. 2023;16:558–569.
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