Oxidative stress markers in breast cancer

Yıl 2024, Cilt: 17 Sayı: 3, 402 - 411, 05.07.2024

Özge Fenercioğlu , Giray Bozkaya , Nuriye Uzuncan , Baha Zengel

https://doi.org/10.31362/patd.1388561

Öz

Purpose: The aim of this study was to compare serum Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Oxidative Stress Index (OSI) and Ischemia Modified Albumin (IMA) levels in breast cancer patients and healthy women and to determine whether there is a relationship between oxidative stress markers and breast cancer.
Materials and methods: Newly diagnosed 106 breast cancer patients at the Bozyaka Training and Research Hospital General Surgery Clinic and 30 healthy women were included in the study. Serum levels of IMA, TAS, TOS were analyzed by spectrophotometric methods.
Results: IMA, TOS and OSI values were found significantly higher in the breast cancer group. Although the TAS values in patients with breast cancer were lower than the control group, the difference was not statistically significant.
Conclusions: In our study, it was seen that oxidative stress levels increased in breast cancer patients due to decreased TAS, and significantly increased IMA, TOS and OSI results. There was no correlation of histopathologic findings with IMA, TOS and OSI levels in terms of tumor grade and size. Disturbed oxidative stress status and IMA may contribute to the pathogenesis of breast cancer and more comprehensive studies are needed for prognostic value.

Anahtar Kelimeler

Breast cancer, biomarkers, ischemia-modified albumin, oxidative stress

Meme kanserinde oksidatif stres belirteçleri

Öz

Amaç: Çalışmamızda oksidatif stres ile meme kanseri arasında ilişki olup olmadığını araştırmak için, meme kanseri hastalarında ve sağlıklı kadınlarda serumda Total Antioksidan Seviye (TAS), Total Oksidan Seviye (TOS), Oksidatif Stres İndeksi (OSİ) ve İskemi Modifiye Albumin (İMA) değerlerinin karşılaştırması amaçlandı.
Gereç ve yöntem: Bozyaka Eğitim ve Araştırma Hastanesi Genel Cerrahi Kliniği’nde yeni tanı almış ve henüz tedavi almamış 106 meme kanseri hastası ve sağlıklı 30 kadın çalışmaya alındı. Serum TAS, TOS ve İMA düzeyleri spektrofotometrik yöntemle analiz edildi.
Bulgular: Meme kanseri grubunda İMA, TOS ve OSİ düzeyleri, istatistiksel olarak anlamlı yüksek bulundu. TAS değerleri ise, meme kanserli hastalarda kontrol grubuna göre düşük olmasına rağmen, aradaki fark istatistiksel olarak anlamlı değildi.
Sonuç: Çalışmamızda meme kanseri hastalarında azalmış TAS, anlamlı derecede artmış İMA, TOS ve OSİ sonuçları sebebiyle oksidatif stres düzeylerinin arttığı anlaşılmaktadır. IMA, TOS ve OSI meme kanseri patofizyolojisinde önemli bir belirteç olup prognostik değer için daha kapsamlı çalışmalara ihtiyaç duyulmaktadır.

Anahtar Kelimeler

Meme kanseri, biyobelirteçler, iskemi modifiye albumin, oksidatif stres

Kaynakça

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