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Genel veya spinal anestezi ile yapılan total diz artroplastisinde peroperatif lokal traneksamik asit uygulamasının kanamaya etkisi

Yıl 2025, Cilt: 18 Sayı: 2, 256 - 269, 01.04.2025
https://doi.org/10.31362/patd.1500706

Öz

Amaç: Bu retrospektif çalışmada, genel veya spinal anestezi altında yapılan total diz artroplastisinde lokal traneksamik kullanımının postoperatif kanama üzerine etkisinin karşılaştırması amaçlandı.
Gereç ve yöntem: Bu çalışmada 2017-2023 tarihleri arasında total diz artroplastisi uygulanan primer osteoartritli 95 dizdeki postoperatif kanama miktarları analiz edildi. Genel veya spinal anestezi uygulanan hastalar perioperatif lokal traneksamik asit verilip verilmemesine göre dört gruba ayrıldı. Traneksamik asit uygulaması 1 gr olarak artroplastisi sonrası çevre yumuşak dokulara lokal olarak yapıldı. Çalışmada postoperatif hemogram değişiklikleri, dren miktarları ve transfüzyon ihtiyaçları değerlendirildi.
Bulgular: Grup 4'te, postoperatif ilk 24 saat içinde hemoglobin düzeylerinde anlamlı düzeyde bir düşüş görüldü (p1:0,001; p2:0,000; p3:0,001). Üçüncü gün hemoglobin değerlerinde Grup 1-4 arasında istatistiksel farklılık yoktu (p:0,117). Grup 3'te postoperatif hemoglobin değerleri diğer gruplara göre istatistiksel olarak yüksekti (p1:0,019; p2:0,003). Grup 4'te Grup 1-3'e göre anlamlı derecede yüksek dren hacimleri görüldü (p=0,000). Grup 1'deki drenden gelen miktar istatistiksel olarak anlamlı derecede düşüktü (p1:0,001; p2:0,032). 2 ünite (%6,1) replasman miktarı değerlendirildiğinde, Grup 3'te kan replasman oranları (%6.1) diğer gruplara göre düşüktü (p1:0,002; p2:0,000).
Sonuç: Çalışma, total diz artroplastisinde lokal olarak uygulanan traneksamik asidin postoperatif kanamayı azalttığını, hemoglobin seviyelerini koruduğunu ve drenaj hacimlerini ve transfüzyon gereksinimlerini azalttığını buldu. Potansiyel kanama ile ilişkili komplikasyonları ve maliyetleri azaltmaya katkıda bulunabilir.

Etik Beyan

Araştırma için Sağlık Bilimleri Üniversitesi Şişli Hamidiye Etfal Eğitim ve Araştırma Hastanesi SUAM Klinik Araştırmalar Etik Kurulu'ndan 13/06/2023 (İzin numarası 3971) izin alındı.

Kaynakça

  • 1. Hart A, Khalil JA, Carli A, Huk O, Zukor D, Antoniou J. Blood transfusion in primary total hip and knee arthroplasty. Incidence, risk factors, and thirty-day complication rates. J Bone Joint Surg Am 2014;96:1945-1951. https://doi.org/10.2106/JBJS.N.00077
  • 2. Kato H, Nakayama T, Uruma M, et al. A retrospective observational study to assess adverse transfusion reactions of patients with and without prior transfusion history. Vox Sang 2015;108:243-250. https://doi.org/10.1111/vox.12208
  • 3. Bernard AC, Davenport DL, Chang PK, Vaughan TB, Zwischenberger JB. Intraoperative transfusion of 1 U to 2 U packed red blood cells is associated with increased 30-day mortality, surgical-site infection, pneumonia, and sepsis in general surgery patients. J Am Coll Surg 2009;208:931-937. https://doi.org/10.1016/j.jamcollsurg.2008.11.019
  • 4. Browne JA, Adib F, Brown TE, Novicoff WM. Transfusion rates are increasing following total hip arthroplasty: risk factors and outcomes. J Arthroplasty 2013;28:34-37. https://doi.org/10.1016/j.arth.2013.03.035
  • 5. Banerjee S, Issa K, Kapadia BH, et al. Intraoperative nonpharmacotherapeutic blood management strategies in total knee arthroplasty. J Knee Surg 2013;26:387-393. https://doi.org/10.1055/s-0033-1353993
  • 6. Chareancholvanich K, Siriwattanasakul P, Narkbunnam R, Pornrattanamaneewong C. Temporary clamping of drain combined with tranexamic acid reduce blood loss after total knee arthroplasty: a prospective randomized controlled trial. BMC Musculoskelet Disord 2012;13:124. https://doi.org/10.1186/1471-2474-13-124
  • 7. Fillingham YA, Ramkumar DB, Jevsevar DS, et al. The efficacy of tranexamic acid in total knee arthroplasty: a network meta-analysis. J Arthroplasty 2018;33:3090-3098.e1. https://doi.org/10.1016/j.arth.2018.04.043
  • 8. Cam N, Balkanlı B, Altuntaş Y, Kanar M, Özdemir HM. The effect of local tranexamic acid administration on blood loss and transfusion in total knee arthroplasty: a retrospective study. Sisli Etfal Hastan tip Bul 2023;57:245-249. https://doi.org/10.14744/SEMB.2023.42800
  • 9. Heckmann ND, De A, Porter KR, Stambough JB. Spinal versus general anesthesia in total knee arthroplasty: are there differences in complication and readmission rates? J Arthroplasty 2023;38:673-679.e1. https://doi.org/10.1016/j.arth.2022.10.036
  • 10. Good L, Peterson E, Lisander B. Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement. Br J Anaesth 2003;90:596-599. https://doi.org/10.1093/bja/aeg111
  • 11. Felson DT, Naimark A, Anderson J, Kazis L, Castelli W, Meenan RF. The prevalence of knee osteoarthritis in the elderly. The framingham osteoarthritis study. Arthritis Rheum 1987;30:914-918. https://doi.org/10.1002/art.1780300811
  • 12. Driban JB, Bannuru RR, Eaton CB, et al. The incidence and characteristics of accelerated knee osteoarthritis among women: the Chingford cohort. BMC Musculoskelet Disord 2020;21:60. https://doi.org/10.1186/s12891-020-3073-3
  • 13. Hong JW, Noh JH, Kim DJ. The prevalence of and demographic factors associated with radiographic knee osteoarthritis in Korean adults aged ≥ 50 years: The 2010-2013 Korea National Health and Nutrition Examination Survey. PLoS One 2020;15:e0230613. https://doi.org/10.1371/journal.pone.0230613
  • 14. Pierson JL, Hannon TJ, Earles DR. A blood-conservation algorithm to reduce blood transfusions after total hip and knee arthroplasty. J Bone Joint Surg Am 2004;86:1512-1518. https://doi.org/10.2106/00004623-200407000-00022
  • 15. Kwon JB, Choi JH, Che SH, Choi WK. The natural course of hemoglobin levels after allogenic blood transfusion in total knee arthroplasty. Medicine (Baltimore) 2023;102:E33387. https://doi.org/10.1097/MD.0000000000033387
  • 16. Cho MR, Jun CM, Song SK, Choi WK. Natural course of hemoglobin level after total knee arthroplasty and the benefit of tranexamic acid injection in the joint. Medicine (Baltimore) 2021;100:e27097. https://doi.org/10.1097/MD.0000000000027097
  • 17. Hartmann B, Junger A, Klasen J, et al. The incidence and risk factors for hypotension after spinal anesthesia induction: an analysis with automated data collection. Anesth Analg 2002;94:1521-1529. https://doi.org/10.1097/00000539-200206000-00027
  • 18. Collins VJ (Vincent J. Principles of anesthesiology : general and regional anesthesia. Lea & Ferbiger, Philadelpia. Lea & Febiger; 1993:1445-1497, 1498-1512. Available from: https://search.worldcat.org/title/23355228. Accessed Mar 12, 2024
  • 19. Schatz C, Plötz W, Beckmann J, Bredow K, Leidl R, Buschner P. Associations of preoperative anemia and postoperative hemoglobin values with hospital costs in total knee arthroplasty (TKA). Arch Orthop Trauma Surg 2023;143:6741-6751. https://doi.org/10.1007/s00402-023-04929-4
  • 20. Zhang Y, Zhang JW, Wang BH. Efficacy of tranexamic acid plus drain-clamping to reduce blood loss in total knee arthroplasty: a meta-analysis. Medicine (Baltimore) [Internet]. 2017;96:73-63. https://doi.org/10.1097/MD.0000000000007363
  • 21. Bemelmans Y, Haaren E Van, Boonen B, Hendrickx R, Schotanus M. Low blood transfusion rate after implementation of tranexamic acid for fast- track hip- and knee arthroplasty. An observational study of 5205 patients. Acta Orthop Belg 2021;87:9-16.
  • 22. Franchini M, Mengoli C, Marietta M, et al. Safety of intravenous tranexamic acid in patients undergoing majororthopaedic surgery: a meta-analysis of randomised controlled trials. Blood Transfus 2018;16:36-43. https://doi.org/10.2450//2017.0219-17
  • 23. Poeran J, Rasul R, Suzuki S, et al. Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States: retrospective analysis of effectiveness and safety. BMJ 2014;349:g4829. https://doi.org/10.1136/bmj.g4829
  • 24. Rodgers A, Walker N, Schug S, et al. Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised trials. BMJ;321:1493-1497. https://doi.org/10.1136/bmj.321.7275.1493
  • 25. Yue C, Pei F, Yang P, Xie J, Kang P. Effect of topical tranexamic acid in reducing bleeding and transfusions in TKA. Orthopedics 2015;38:315-324. https://doi.org/10.3928/01477447-20150504-06
  • 26. Wei C, Muthiah A, Gu A, et al. Association of anesthesia type with postoperative outcome and complications in patients undergoing revision total knee arthroplasty. J Knee Surg 2022;35:345-354. https://doi.org/10.1055/s-0040-1713776
  • 27. Lee SY, Kim MK, Ahn EJ, Jung YH. Comparison of general and regional anesthesia on short-term complications in patients undergoing total knee arthroplasty: A retrospective study using national health insurance service-national sample cohort. Medicine (Baltimore) 2023;102:e33032. https://doi.org/10.1097/MD.0000000000033032

Effect of peroperative local tranexamic acid admistration on bleeding in total knee arthroplasty performed with general or spinal anesthesia

Yıl 2025, Cilt: 18 Sayı: 2, 256 - 269, 01.04.2025
https://doi.org/10.31362/patd.1500706

Öz

Purpose: This retrospective study aimed to compare the effects of local tranexamic use on postoperative bleeding in total knee arthroplasty performed under general or spinal anesthesia.
Materials and methods: This study analyzed the amount of postoperative bleeding in 95 primary osteoarthritis knees that underwent total knee arthroplasty between 2017 and 2023. Patients who underwent general or spinal anesthesia were divided into four groups according to whether or not local tranexamic acid was administered perioperatively. Tranexamic acid was administered locally to the surrounding soft tissues after arthroplasty as 1 g. Postoperative hemogram changes, drain amounts, and transfusion needs were evaluated in the study.
Results: In Group 4, a significant decrease in hemoglobin levels was observed within the first 24 hours postoperatively (p1:0.001; p2:0.000; p3:0.001). There was no statistically significant difference in hemoglobin values on the third day between Groups 1-4 (p:0.117). Postoperative hemoglobin values in Group 3 were statistically higher than the other groups (p1:0.019; p2:0.003). Significantly higher drain volumes were seen in Group 4 compared to Groups 1-3 (p=0.000). The amount coming from the drain in Group 1 was statistically significantly lower (p1:0.001; p2:0.032). When the replacement amount of 2 units (6.1%) was evaluated, blood replacement rates in Group 3 (6.1%) were lower than in the other groups (p1:0.002; p2:0.000).
Discussion: The study found that locally applied tranexamic acid in total knee arthroplasty reduced postoperative bleeding, maintained hemoglobin levels, and reduced drainage volumes and transfusion requirements. It may contribute to reducing potential bleeding-related complications and costs.

Etik Beyan

Permission was received for the study from the Health Sciences University Şişli Hamidiye Etfal Training and Research Hospital SUAM Clinical Research Ethics Committee (13/06/2023 (Permission number 3971).

Kaynakça

  • 1. Hart A, Khalil JA, Carli A, Huk O, Zukor D, Antoniou J. Blood transfusion in primary total hip and knee arthroplasty. Incidence, risk factors, and thirty-day complication rates. J Bone Joint Surg Am 2014;96:1945-1951. https://doi.org/10.2106/JBJS.N.00077
  • 2. Kato H, Nakayama T, Uruma M, et al. A retrospective observational study to assess adverse transfusion reactions of patients with and without prior transfusion history. Vox Sang 2015;108:243-250. https://doi.org/10.1111/vox.12208
  • 3. Bernard AC, Davenport DL, Chang PK, Vaughan TB, Zwischenberger JB. Intraoperative transfusion of 1 U to 2 U packed red blood cells is associated with increased 30-day mortality, surgical-site infection, pneumonia, and sepsis in general surgery patients. J Am Coll Surg 2009;208:931-937. https://doi.org/10.1016/j.jamcollsurg.2008.11.019
  • 4. Browne JA, Adib F, Brown TE, Novicoff WM. Transfusion rates are increasing following total hip arthroplasty: risk factors and outcomes. J Arthroplasty 2013;28:34-37. https://doi.org/10.1016/j.arth.2013.03.035
  • 5. Banerjee S, Issa K, Kapadia BH, et al. Intraoperative nonpharmacotherapeutic blood management strategies in total knee arthroplasty. J Knee Surg 2013;26:387-393. https://doi.org/10.1055/s-0033-1353993
  • 6. Chareancholvanich K, Siriwattanasakul P, Narkbunnam R, Pornrattanamaneewong C. Temporary clamping of drain combined with tranexamic acid reduce blood loss after total knee arthroplasty: a prospective randomized controlled trial. BMC Musculoskelet Disord 2012;13:124. https://doi.org/10.1186/1471-2474-13-124
  • 7. Fillingham YA, Ramkumar DB, Jevsevar DS, et al. The efficacy of tranexamic acid in total knee arthroplasty: a network meta-analysis. J Arthroplasty 2018;33:3090-3098.e1. https://doi.org/10.1016/j.arth.2018.04.043
  • 8. Cam N, Balkanlı B, Altuntaş Y, Kanar M, Özdemir HM. The effect of local tranexamic acid administration on blood loss and transfusion in total knee arthroplasty: a retrospective study. Sisli Etfal Hastan tip Bul 2023;57:245-249. https://doi.org/10.14744/SEMB.2023.42800
  • 9. Heckmann ND, De A, Porter KR, Stambough JB. Spinal versus general anesthesia in total knee arthroplasty: are there differences in complication and readmission rates? J Arthroplasty 2023;38:673-679.e1. https://doi.org/10.1016/j.arth.2022.10.036
  • 10. Good L, Peterson E, Lisander B. Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement. Br J Anaesth 2003;90:596-599. https://doi.org/10.1093/bja/aeg111
  • 11. Felson DT, Naimark A, Anderson J, Kazis L, Castelli W, Meenan RF. The prevalence of knee osteoarthritis in the elderly. The framingham osteoarthritis study. Arthritis Rheum 1987;30:914-918. https://doi.org/10.1002/art.1780300811
  • 12. Driban JB, Bannuru RR, Eaton CB, et al. The incidence and characteristics of accelerated knee osteoarthritis among women: the Chingford cohort. BMC Musculoskelet Disord 2020;21:60. https://doi.org/10.1186/s12891-020-3073-3
  • 13. Hong JW, Noh JH, Kim DJ. The prevalence of and demographic factors associated with radiographic knee osteoarthritis in Korean adults aged ≥ 50 years: The 2010-2013 Korea National Health and Nutrition Examination Survey. PLoS One 2020;15:e0230613. https://doi.org/10.1371/journal.pone.0230613
  • 14. Pierson JL, Hannon TJ, Earles DR. A blood-conservation algorithm to reduce blood transfusions after total hip and knee arthroplasty. J Bone Joint Surg Am 2004;86:1512-1518. https://doi.org/10.2106/00004623-200407000-00022
  • 15. Kwon JB, Choi JH, Che SH, Choi WK. The natural course of hemoglobin levels after allogenic blood transfusion in total knee arthroplasty. Medicine (Baltimore) 2023;102:E33387. https://doi.org/10.1097/MD.0000000000033387
  • 16. Cho MR, Jun CM, Song SK, Choi WK. Natural course of hemoglobin level after total knee arthroplasty and the benefit of tranexamic acid injection in the joint. Medicine (Baltimore) 2021;100:e27097. https://doi.org/10.1097/MD.0000000000027097
  • 17. Hartmann B, Junger A, Klasen J, et al. The incidence and risk factors for hypotension after spinal anesthesia induction: an analysis with automated data collection. Anesth Analg 2002;94:1521-1529. https://doi.org/10.1097/00000539-200206000-00027
  • 18. Collins VJ (Vincent J. Principles of anesthesiology : general and regional anesthesia. Lea & Ferbiger, Philadelpia. Lea & Febiger; 1993:1445-1497, 1498-1512. Available from: https://search.worldcat.org/title/23355228. Accessed Mar 12, 2024
  • 19. Schatz C, Plötz W, Beckmann J, Bredow K, Leidl R, Buschner P. Associations of preoperative anemia and postoperative hemoglobin values with hospital costs in total knee arthroplasty (TKA). Arch Orthop Trauma Surg 2023;143:6741-6751. https://doi.org/10.1007/s00402-023-04929-4
  • 20. Zhang Y, Zhang JW, Wang BH. Efficacy of tranexamic acid plus drain-clamping to reduce blood loss in total knee arthroplasty: a meta-analysis. Medicine (Baltimore) [Internet]. 2017;96:73-63. https://doi.org/10.1097/MD.0000000000007363
  • 21. Bemelmans Y, Haaren E Van, Boonen B, Hendrickx R, Schotanus M. Low blood transfusion rate after implementation of tranexamic acid for fast- track hip- and knee arthroplasty. An observational study of 5205 patients. Acta Orthop Belg 2021;87:9-16.
  • 22. Franchini M, Mengoli C, Marietta M, et al. Safety of intravenous tranexamic acid in patients undergoing majororthopaedic surgery: a meta-analysis of randomised controlled trials. Blood Transfus 2018;16:36-43. https://doi.org/10.2450//2017.0219-17
  • 23. Poeran J, Rasul R, Suzuki S, et al. Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States: retrospective analysis of effectiveness and safety. BMJ 2014;349:g4829. https://doi.org/10.1136/bmj.g4829
  • 24. Rodgers A, Walker N, Schug S, et al. Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised trials. BMJ;321:1493-1497. https://doi.org/10.1136/bmj.321.7275.1493
  • 25. Yue C, Pei F, Yang P, Xie J, Kang P. Effect of topical tranexamic acid in reducing bleeding and transfusions in TKA. Orthopedics 2015;38:315-324. https://doi.org/10.3928/01477447-20150504-06
  • 26. Wei C, Muthiah A, Gu A, et al. Association of anesthesia type with postoperative outcome and complications in patients undergoing revision total knee arthroplasty. J Knee Surg 2022;35:345-354. https://doi.org/10.1055/s-0040-1713776
  • 27. Lee SY, Kim MK, Ahn EJ, Jung YH. Comparison of general and regional anesthesia on short-term complications in patients undergoing total knee arthroplasty: A retrospective study using national health insurance service-national sample cohort. Medicine (Baltimore) 2023;102:e33032. https://doi.org/10.1097/MD.0000000000033032
Toplam 27 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Ortopedi
Bölüm Araştırma Makalesi
Yazarlar

Bahadır Balkanlı 0000-0003-4501-9090

İsmail Tüter 0000-0002-8766-981X

Enver İpek 0000-0001-6205-1207

Erken Görünüm Tarihi 23 Ekim 2024
Yayımlanma Tarihi 1 Nisan 2025
Gönderilme Tarihi 13 Haziran 2024
Kabul Tarihi 15 Ekim 2024
Yayımlandığı Sayı Yıl 2025 Cilt: 18 Sayı: 2

Kaynak Göster

AMA Balkanlı B, Tüter İ, İpek E. Effect of peroperative local tranexamic acid admistration on bleeding in total knee arthroplasty performed with general or spinal anesthesia. Pam Tıp Derg. Nisan 2025;18(2):256-269. doi:10.31362/patd.1500706
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