Endokrin Bozucular

Öz

Endokrin bozucular, endokrin sistem tarafından sentezlenen endojen kimyasalların aktivitelerini bir şekilde taklit ettikleri, blokladıkları ya da değiştirdikleri için özel ilgi konusudurlar. Diğer birçok organın yanında, özellikle üriner sistemi ve tiroid bezlerini etkilemektedirler. Endokrin bozucu kimyasallar östrojen ve androjen reseptörleri ile reaksiyona girip, endojen hormonların agonist ya da antagonistleri olarak etki gösterebilirler. Son on yılda reprodüktif organ anomalileri, testiküler kanser, erkek doğum oranlarında azalma ve semen kalitesinde düşme rapor eden birçok çalışma yayınlanmıştır. Bu derlemede, endokrin bozucuların reprodüktif sağlık üzerine olan etkileri yakın dö- neme ait literatür ışığında tartışılmıştır

Anahtar Kelimeler

• Endokrin bozucular,üreme sistemi,çocuk

Endocrine Disruptors

Abstract

Endocrine disruptors are of special interest because they mimic, block, or insome way alter the activity of endogenous chemicals that are synthesized bythe endocrine system. Besides many other organs, they especially affect theurinary system and the thyroid glands. Endocrine-disrupting chemicals aretypically identified as compounds that can interact with oestrogen or androgen receptors and thus act as agonists or antagonists of endogenoushormones. During the last decade, numerous studies have been published,reporting an increase in reproductive organ anomalies, as well as in testicular cancer, and a decline in the relative number of male births, and insemen quality. In this review, the effects of endocrine distruptors on the reproductive health are discussed in the light of the recent literature

Keywords

• Endocrine disruptors,reproductive system,child

Kaynakça

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