Serum Autologous Skin Test in Children with Chronic Urticaria: Is it Related to The Severity of The Disease?

Abstract

INTRODUCTION: We aimed to contribute to the limited number of studies that investigated the association between autologous serum test positivity and the severity of childhood chronic spontaneous urticaria. MATERIALS and METHODS: Eighty-seven pediatric patients who underwent autologous serum test for chronic spontaneous urticaria were retrospectively investigated. Urticaria severity was assessed according to urticaria activity score. RESULTS: In 19 of our patients (21.83%), the autologous serum test was positive. When clinical and laboratory parameters of patients with positive and negative autologous serum test are evaluated; age, sex, onset of symptoms, total IgE and eosinophil (%) were not statistically significant. Patients with positive autologous serum test had significantly higher urticaria activity scores (p 0.001). CONCLUSIONS: In our study, urticaria activity score was found higher in patients with autologous serum test positive. The choice of treatment for patients with a positive autologous serum test will ensure that symptoms and the quality of life of the patients will be improved faster if they are taken into consideration that the disease may be more severe.

Keywords

• children,autologous serum test

Kronik Ürtiker’li Çocuklarda Serum Otolog Deri Testi: Hastalığın Ağırlığı İle İlişkisi Var Mı?

Öz

GİRİŞ ve AMAÇ: Çalışmamızda Otolog serum testi pozitifliği ile çocukluk çağı kronik spontan ürtikerinin ağırlığı arasındaki ilişkiyi araştıran kısıtlı sayıda çalışmaya katkıda bulunmak amaçlanmıştır. YÖNTEM ve GEREÇLER: Kronik spontan ürtiker nedeniyle otolog serum testi yapılmış 87 çocuk hastanın verileri geriye dönük incelendi. Ürtiker ağırlığı ürtiker aktivite skoruna göre değerlendirildi. BULGULAR: Hastalarımızın 19’ında (%21.83) otolog serum testi pozitif olarak tespit edildi. Otolog serum testi pozitif ve negatif olan hastaların klinik ve laboratuvar parametreleri değerlendirildiğinde; yaş, cins, semptomların başlama yaşı, total IgE ve eozinofil (%) açısından istatistiksel anlamlılık saptanmadı. Otolog serum testi pozitif olan hastaların ürtiker aktivite skorları anlamlı olarak daha yüksek saptandı (p 0,001). TARTIŞMA ve SONUÇ: Çalışmamızda otolog serum testipozitif hastalarda ürtiker aktivite skoru daha yüksek bulunmuştur. Pozitif otolog serum testine sahip hastaların tedavi seçimi hastalığın daha şiddetli olabileceği ihtimalini dikkate alarak yapıldığında daha çabuksemptom kontrolünü ve hastaların yaşam kalitesinin düzelmesini sağlayacaktır.

Anahtar Kelimeler

• çocuk,otolog serum testi,kronik spontan ürtiker,ürtiker aktivite skoru

Kaynakça

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