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Geç tanı alan konjenital hipotiroidli bir çocukta L-tiroksin tedavisi sonrası saç dökülmesi Hair loss after treatment with L-thyroxine in a child with a delayed diagnosis of congenital hypothyroidism

Yıl 2017, Cilt: 15 Sayı: 2, 79 - 83, 01.08.2017

Ayşegül Yalçınkaya İyidal Fatma Arzu Kılıç

Öz

Giriş:

Biz burada L-tiroksin tedavisi başlandıktan sonra saç dökülmesi şikayeti olan
bu olguyla L-tiroksin tedavisinin nadir görülen yan etkisini sunmayı amaçladık

Olgu:

Polikliniğimize 3 yıl önce konjenital hipotiroidizm tanısı alan 13 yaşında bir
kız hasta L-tiroksin tedavisi başlandıktan sonra difüz saç kaybı şikayeti
nedeni ile başvurdu

Tartışma:

Biz bu olgu yoluyla konjenital hipotiroidi nedeni ile L-tiroksin replasman
tedavisine başlandıktan sonra saç dökülmesinin izlenmesini belki de kıl
siklusunda yer alan hormon ve büyüme faktörlerinin arasındaki dengenin
bozulması sonucu oluşan bir yan etki olduğunu düşünmekteyiz.


ABSTRACT



Introduction: In this case report, we
aimed to emphasize the rare side effect of L-thyroxine by describing the case
who had suffered hair loss after being treated with L-thyroxine.

Case report: A 13-year old girl was admitted to our clinic with diffuse hair
loss which was stated to start after treatment with L-thyroxine. She was
diagnosed with congenital hypothyroidism at 10 years of age.

Discussion: We suggest that hair loss following L-thyroxine replacement therapy
for congenital hypothyroidism in this case was due to the side-effect of
therapy, which probably caused 
impairment in the balance between the effects of the hormones and growth
factors in hair cycle.

Anahtar Kelimeler

Konjenital hipotiroidi L-tiroksin saç dökülmesi Congenital hypothyroidism L-thyroxine hair loss

Kaynakça

  • 1-Paus R, Olsen Elise A, Messenger Andrew G. Hair Growth Disorders. In Wolff K, Goldsmıth L, Katz S (eds): Fitzpatrick's Dermatology in General Medicine 7th, Edition; United States of America: McGrawHill 2008; 753-77.
  • 2-Al-Refu K. Hair loss in children: Common and uncommon causes; clinical and epidemiological study in jordan. Int J Trichology. 2013;5(4):185-9.
  • 3-Büyükgebiz A. Newborn screening for congenital hypothyroidism. J Clin Res Pediatr Endocrinol. 2013;5 Suppl 1:8-12. doi: 10.4274/jcrpe.845. Epub 2012 Nov 15.
  • 4-Abduljabbar MA, Afifi AM. Congenital hypothyroidism. J Pediatr Endocrinol Metab. 2012;25(1-2):13-29.
  • 5-Jackson AJ, Price VH. How to diagnose hair loss. Dermatol Clin. 2013 Jan;31(1):21-8.
  • 6-Paus R, Peker S, Sundberg JP. Biology of Hair and Nails. In: Bolognia J, Jorizzo J, Rapini R (eds): Dermatology 2nd Edition, Edition; Spain: Mosby-Elsevier 2008; 965-8.
  • 7- van Beek N, Bodó E, Kromminga A, Gáspár E, Meyer K, Zmijewski MA ve ark. Thyroid hormones directly alter human hair follicle functions: anagen prolongation and stimulation of both hair matrix keratinocyte proliferation and hair pigmentation. J Clin Endocrinol Metab. 2008 Nov; 93: 4381-8.
  • 8- Bodó E, Kromminga A, Bíró T, Borbíró I, Gáspár E, Zmijewski MA ve ark. Human female hair follicles are a direct, nonclassical target for thyroid-stimulating hormone. J Invest Dermatol. 2009 May;129:1126-39.
  • 9- Hatipoglu N, Kurtoglu S, Keskin M, Kendirci M.. An occasional side effect in the treatment of congenital hypothyroidism: hair loss. Eur J Pediatr. 2006 Jul; 165: 500-1.

Yıl 2017, Cilt: 15 Sayı: 2, 79 - 83, 01.08.2017

Ayşegül Yalçınkaya İyidal Fatma Arzu Kılıç

Öz

Kaynakça

  • 1-Paus R, Olsen Elise A, Messenger Andrew G. Hair Growth Disorders. In Wolff K, Goldsmıth L, Katz S (eds): Fitzpatrick's Dermatology in General Medicine 7th, Edition; United States of America: McGrawHill 2008; 753-77.
  • 2-Al-Refu K. Hair loss in children: Common and uncommon causes; clinical and epidemiological study in jordan. Int J Trichology. 2013;5(4):185-9.
  • 3-Büyükgebiz A. Newborn screening for congenital hypothyroidism. J Clin Res Pediatr Endocrinol. 2013;5 Suppl 1:8-12. doi: 10.4274/jcrpe.845. Epub 2012 Nov 15.
  • 4-Abduljabbar MA, Afifi AM. Congenital hypothyroidism. J Pediatr Endocrinol Metab. 2012;25(1-2):13-29.
  • 5-Jackson AJ, Price VH. How to diagnose hair loss. Dermatol Clin. 2013 Jan;31(1):21-8.
  • 6-Paus R, Peker S, Sundberg JP. Biology of Hair and Nails. In: Bolognia J, Jorizzo J, Rapini R (eds): Dermatology 2nd Edition, Edition; Spain: Mosby-Elsevier 2008; 965-8.
  • 7- van Beek N, Bodó E, Kromminga A, Gáspár E, Meyer K, Zmijewski MA ve ark. Thyroid hormones directly alter human hair follicle functions: anagen prolongation and stimulation of both hair matrix keratinocyte proliferation and hair pigmentation. J Clin Endocrinol Metab. 2008 Nov; 93: 4381-8.
  • 8- Bodó E, Kromminga A, Bíró T, Borbíró I, Gáspár E, Zmijewski MA ve ark. Human female hair follicles are a direct, nonclassical target for thyroid-stimulating hormone. J Invest Dermatol. 2009 May;129:1126-39.
  • 9- Hatipoglu N, Kurtoglu S, Keskin M, Kendirci M.. An occasional side effect in the treatment of congenital hypothyroidism: hair loss. Eur J Pediatr. 2006 Jul; 165: 500-1.
Toplam 9 adet kaynakça vardır.

Ayrıntılar

Bölüm Olgu
Yazarlar

Ayşegül Yalçınkaya İyidal

Fatma Arzu Kılıç Bu kişi benim

Yayımlanma Tarihi 1 Ağustos 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 15 Sayı: 2

Kaynak Göster

APA Yalçınkaya İyidal, A., & Kılıç, F. A. (2017). Geç tanı alan konjenital hipotiroidli bir çocukta L-tiroksin tedavisi sonrası saç dökülmesi Hair loss after treatment with L-thyroxine in a child with a delayed diagnosis of congenital hypothyroidism. Güncel Pediatri, 15(2), 79-83.
AMA Yalçınkaya İyidal A, Kılıç FA. Geç tanı alan konjenital hipotiroidli bir çocukta L-tiroksin tedavisi sonrası saç dökülmesi Hair loss after treatment with L-thyroxine in a child with a delayed diagnosis of congenital hypothyroidism. Güncel Pediatri. Ağustos 2017;15(2):79-83.
Chicago Yalçınkaya İyidal, Ayşegül, ve Fatma Arzu Kılıç. “Geç Tanı Alan Konjenital Hipotiroidli Bir çocukta L-Tiroksin Tedavisi Sonrası Saç dökülmesi Hair Loss After Treatment With L-Thyroxine in a Child With a Delayed Diagnosis of Congenital Hypothyroidism”. Güncel Pediatri 15, sy. 2 (Ağustos 2017): 79-83.
EndNote Yalçınkaya İyidal A, Kılıç FA (01 Ağustos 2017) Geç tanı alan konjenital hipotiroidli bir çocukta L-tiroksin tedavisi sonrası saç dökülmesi Hair loss after treatment with L-thyroxine in a child with a delayed diagnosis of congenital hypothyroidism. Güncel Pediatri 15 2 79–83.
IEEE A. Yalçınkaya İyidal ve F. A. Kılıç, “Geç tanı alan konjenital hipotiroidli bir çocukta L-tiroksin tedavisi sonrası saç dökülmesi Hair loss after treatment with L-thyroxine in a child with a delayed diagnosis of congenital hypothyroidism”, Güncel Pediatri, c. 15, sy. 2, ss. 79–83, 2017.
ISNAD Yalçınkaya İyidal, Ayşegül - Kılıç, Fatma Arzu. “Geç Tanı Alan Konjenital Hipotiroidli Bir çocukta L-Tiroksin Tedavisi Sonrası Saç dökülmesi Hair Loss After Treatment With L-Thyroxine in a Child With a Delayed Diagnosis of Congenital Hypothyroidism”. Güncel Pediatri 15/2 (Ağustos 2017), 79-83.
JAMA Yalçınkaya İyidal A, Kılıç FA. Geç tanı alan konjenital hipotiroidli bir çocukta L-tiroksin tedavisi sonrası saç dökülmesi Hair loss after treatment with L-thyroxine in a child with a delayed diagnosis of congenital hypothyroidism. Güncel Pediatri. 2017;15:79–83.
MLA Yalçınkaya İyidal, Ayşegül ve Fatma Arzu Kılıç. “Geç Tanı Alan Konjenital Hipotiroidli Bir çocukta L-Tiroksin Tedavisi Sonrası Saç dökülmesi Hair Loss After Treatment With L-Thyroxine in a Child With a Delayed Diagnosis of Congenital Hypothyroidism”. Güncel Pediatri, c. 15, sy. 2, 2017, ss. 79-83.
Vancouver Yalçınkaya İyidal A, Kılıç FA. Geç tanı alan konjenital hipotiroidli bir çocukta L-tiroksin tedavisi sonrası saç dökülmesi Hair loss after treatment with L-thyroxine in a child with a delayed diagnosis of congenital hypothyroidism. Güncel Pediatri. 2017;15(2):79-83.