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Kanser Tedavisi Alan Çocuklarda Bulantı-Kusmaya Yönelik Semptom Yönetimi: Kanıt Temelli Uygulamalar

Yıl 2019, Cilt: 17 Sayı: 1, 170 - 182, 01.04.2019

Öz

Kemoterapiye bağlı oluşan
bulantı-kusma kanser tedavisi alan çocuklarda en yaygın görülen ve
multidisipliner yaklaşım gerektiren semptomlar arasındadır. Son yıllarda
antiemetik tedavi protokolleriyle ilgili gelişmelere rağmen, bulantı-kusmayla
baş etme güçlükleri günümüzde hala devam etmektedir. Kontrol altına alınamayan
bulantı-kusma deneyimleyen çocuklar, tedavi sürecinde uzama, yaşam kalitesinde
azalma, sıvı-elektrolit dengesizliği, yetersiz beslenme ve tedaviye uyumda
azalma gibi birçok sorun yaşamaktadır. Bu derlemede, çocuklarda bulantı-kusmaya
yönelik kanıta dayalı, güncel ve güvenilir bilgilerin hemşireler için rehber
niteliği taşıması amaçlanmıştır. Bulantı-kusmayı azaltmak için farmakolojik
yöntemlerin yanında integratif sağlık yaklaşımları da tercih edilmektedir.
Hemşireler bulantı-kusmanın optimal düzeyde yönetilmesini sağlamak için yeterli
bilgiye ve donanıma sahip olmalıdır. Bu doğrultuda, kanıta dayalı tedavileri
uygulama ve integratif yöntemlerle ilgili rehberlik/danışmanlık yapmalı ve
eğitim vermelidir. Bunun yanında, uygulama rehberlerini takip ederek, değişen
bilgiler doğrultusunda klinik uygulamalarını güncelleştirmelidir. Kemoterapi
protokollerine uygun standart, güncel antiemetik tedavilerin uygulanması
çocukların yaşadığı bulantı-kusma semptomunun önlenmesini/azaltılmasını
sağlayarak çocuk ve ebeveynlerin yaşam kalitesini arttıracaktır. Bu derlemede,
bulantı-kusma yönetiminde uygulanan değerlendirme araçları ve standart tedavi
yöntemlerinin yetersiz olduğu belirlenmiştir. Bu nedenle, bulantı-kusmanın
etkin yönetilmesi için hem farmakolojik hem integratif yöntemlerle ilgili daha
fazla deneysel ve kanıta dayalı çalışmaların yapılması önerilmektedir.

Kaynakça

  • 1. Rodgers C, Kollar D, Taylor O, et al. Nausea and vomiting perspectives among children receiving moderate to highly emetogenic chemotherapy treatment. Cancer nursing 2012;35:203-10.
  • 2. Turan SA, Esenay FI, Güven M. Symptoms in Children After Chemotherapy. Guencel Pediatri 2016;14.
  • 3. Felix‐Ukwu F, Reichert K, Bernhardt MB, Schafer ES, Berger A. Evaluation of aprepitant for acute chemotherapy‐induced nausea and vomiting in children and adolescents with acute lymphoblastic leukemia receiving high‐dose methotrexate. Pediatric blood & cancer 2018;65:e26857.
  • 4. Ruggiero A, Rizzo D, Catalano M, Coccia P, Triarico S, Attiná G. Acute chemotherapy-induced nausea and vomiting in children with cancer: Still waiting for a common consensus on treatment. Journal of International Medical Research 2018:0300060518765324.
  • 5. Velez-Florez G, Velez-Florez MC, Mantilla-Rivas JO, Patarroyo-Rodríguez L, Borrero-León R, Rodríguez-León S. Mind-Body Therapies in Childhood Cancer. Current psychiatry reports 2018;20:58.
  • 6. Yeh C-H, Chiang Y-C, Chien L-C, Lin L, Yang C-P, Chuang H-L. Symptom clustering in older Taiwanese children with cancer. Oncology nursing forum. Vol 352008.
  • 7. Çolaklar H. Evidence-Based Information Services: An Example of a Literature Review. Journal of Balkan Libraries Union 2017;5:11-20.
  • 8. Warr D. Chemotherapy-and cancer-related nausea and vomiting. Current oncology 2008;15:S4.
  • 9. Hockenberry MJ, Rodgers CC. Nausea, Vomiting, Anorexia, and Fatigue. Pediatric Psycho-Oncology: A Quick Reference on the Psychosocial Dimensions of Cancer Symptom Management 2015:79.
  • 10. Dupuis LL, Sung L, Molassiotis A, Orsey AD, Tissing W, van de Wetering M. 2016 updated MASCC/ESMO consensus recommendations: Prevention of acute chemotherapy-induced nausea and vomiting in children. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2017;25:323-31.
  • 11. Roila F, Warr D, Aapro M, et al. Delayed emesis: moderately emetogenic chemotherapy (single-day chemotherapy regimens only). Supportive Care in Cancer 2011;19:57-62.
  • 12. Herrstedt J. Antiemetics: an update and the MASCC guidelines applied in clinical practice. Nature Reviews Clinical Oncology 2008;5:32.
  • 13. Dupuis LL, Robinson PD, Boodhan S, et al. Guideline for the prevention and treatment of anticipatory nausea and vomiting due to chemotherapy in pediatric cancer patients. Pediatric blood & cancer 2014;61:1506-12.
  • 14. Flank J, Robinson PD, Holdsworth M, et al. Guideline for the Treatment of Breakthrough and the Prevention of Refractory Chemotherapy‐Induced Nausea and Vomiting in Children With Cancer. Pediatric blood & cancer 2016;63:1144-51.
  • 15. Şişman H. BARF Bulantı Ölçeği’ nin Geçerlilik ve Güvenirlik Çalışması İstanbul: T.C. Acıbadem Üniversitesi Sağlık Bilimleri Enstitüsü; 2015.
  • 16. Conk Z, Başbakkal Z, Yılmaz HB, Bolışık B. Pediatri hemşireliği. Akademisyen Tıp Kitabevi; 2013.
  • 17. Okumura LM, Rodrigues DA, Ferreira MAP, Moreira LB. Aprepitant in pediatric patients using moderate and highly emetogenic protocols: a systematic review and meta‐analyses of randomized controlled trials. British journal of clinical pharmacology 2017;83:1108-17.
  • 18. Aapro M, Gralla RJ, Herrstedt J, Molassiotis A, Roila F. MASCC/ESMO antiemetic guideline 2016. Dostęp: http://www mascc org/assets/Guidelines-Tools/mascc_antiemetic_guidelines_ english _2016_v 2016;1.
  • 19. Navari RM. 5-HT3 receptors as important mediators of nausea and vomiting due to chemotherapy. Biochimica et Biophysica Acta (BBA)-Biomembranes 2015;1848:2738-46.
  • 20. Tricco AC, Blondal E, Veroniki AA, et al. Comparative safety and effectiveness of serotonin receptor antagonists in patients undergoing chemotherapy: a systematic review and network meta-analysis. BMC medicine 2016;14:216.
  • 21. Jain S, Kapoor G, Koneru S, Vishwakarma G. A randomized, open-label non-inferiority study to compare palonosetron and ondansetron for prevention of acute chemotherapy-induced vomiting in children with cancer receiving moderate or high emetogenic chemotherapy. Supportive Care in Cancer 2018:1-7.
  • 22. Chow R, Warr DG, Navari RM, et al. Should palonosetron be a preferred 5-HT 3 receptor antagonist for chemotherapy-induced nausea and vomiting? An updated systematic review and meta-analysis. Supportive Care in Cancer 2018:1-31.
  • 23. Dupuis LL, Boodhan S, Holdsworth M, et al. Guideline for the prevention of acute nausea and vomiting due to antineoplastic medication in pediatric cancer patients. Pediatric blood & cancer 2013;60:1073-82.
  • 24. Jordan K, Roila F, Molassiotis A, Maranzano E, Clark-Snow RA, Feyer P. Antiemetics in children receiving chemotherapy. MASCC/ESMO guideline update 2009. Supportive Care in Cancer 2011;19:37-42.
  • 25. Kang HJ, Loftus S, DiCristina C, Green S, Pong A, Zwaan CM. Aprepitant for the prevention of chemotherapy‐induced nausea and vomiting in paediatric subjects: An analysis by age group. Pediatric blood & cancer 2018:e27273.
  • 26. Bakhshi S, Batra A, Biswas B, Dhawan D, Paul R, Sreenivas V. Aprepitant as an add-on therapy in children receiving highly emetogenic chemotherapy: a randomized, double-blind, placebo-controlled trial. Supportive Care in Cancer 2015;23:3229-37.
  • 27. Yuan D-M, Li Q, Zhang Q, et al. Efficacy and safety of neurokinin-1 receptor antagonists for prevention of chemotherapy-induced nausea and vomiting: systematic review and meta-analysis of randomized controlled trials. Asian Pac J Cancer Prev 2016;17:1661-75.
  • 28. Ruggiero A, Arena R, Battista A, Rizzo D, Attinà G, Riccardi R. Azole interactions with multidrug therapy in pediatric oncology. European journal of clinical pharmacology 2013;69:1-10.
  • 29. Ruggiero A, Cefalo MG, Coccia P, Mastrangelo S, Maurizi P, Riccardi R. The role of diet on the clinical pharmacology of oral antineoplastic agents. European journal of clinical pharmacology 2012;68:115-22.
  • 30. Lin MLM, Robinson PD, Flank J, Sung L, Dupuis LL. The safety of prochlorperazine in children: a systematic review and meta-analysis. Drug safety 2016;39:509-16.
  • 31. Dupuis LL, Roscoe JA, Olver I, Aapro M, Molassiotis A. 2016 updated MASCC/ESMO consensus recommendations: Anticipatory nausea and vomiting in children and adults receiving chemotherapy. Supportive care in cancer 2017;25:317-21.
  • 32. Rock EM, Sticht MA, Limebeer CL, Parker LA. Cannabinoid regulation of acute and anticipatory nausea. Cannabis and cannabinoid research 2016;1:113-21.
  • 33. Wong SS, Wilens TE. Medical cannabinoids in children and adolescents: a systematic review. Pediatrics 2017;140:e20171818.
  • 34. Uzun S, Kozumplik O, Jakovljević M, Sedić B. Side effects of treatment with benzodiazepines. Psychiatria Danubina 2010;22:90-3.
  • 35. Kreitzer MJ, Koithan M. Integrative nursing. Vol 11. Oxford University Press; 2014.
  • 36. Navari RM. Management of Chemotherapy-Induced Nausea and Vomiting in Pediatric Patients. Paediatric drugs 2017;19:213-22.
  • 37. Jacobs SS. Integrative Therapy Use for Management of Side Effects and Toxicities Experienced by Pediatric Oncology Patients. Children 2014;1:424-40.
  • 38. Momani TeG, Berry DL. Integrative therapeutic approaches for the management and control of nausea in children undergoing cancer treatment: a systematic review of literature. Journal of Pediatric Oncology Nursing 2017;34:173-84.
  • 39. McKeon C, Smith CA, Hardy J, Chang E. Acupuncture and acupressure for chemotherapy-induced nausea and vomiting: a systematic review. Australian Journal of Acupuncture and Chinese Medicine 2013;8:2.
  • 40. Jones E, Isom S, Kemper KJ, McLean TW. Acupressure for chemotherapy-associated nausea and vomiting in children. Journal of the Society for Integrative Oncology 2008;6:141-5.
  • 41. Ndao DH, Ladas EJ, Cheng B, et al. Inhalation aromatherapy in children and adolescents undergoing stem cell infusion: results of a placebo‐controlled double‐blind trial. Psycho‐Oncology 2012;21:247-54.
  • 42. Evans A, Malvar J, Garretson C, Pedroja Kolovos E, Baron Nelson M. The Use of Aromatherapy to Reduce Chemotherapy-Induced Nausea in Children With Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of Pediatric Oncology Nursing 2018:1043454218782133.
  • 43. Mazlum S, Chaharsoughi NT, Banihashem A, Vashani HB. The effect of massage therapy on chemotherapy-induced nausea and vomiting in pediatric cancer. Iranian journal of nursing and midwifery research 2013;18:280.
  • 44. Miladinia M, Baraz S, Mousavi Nouri E, Gholamzadeh Baeis M. Effects of slow-stroke back massage on chemotherapy-induced nausea and vomiting in the pediatrics with acute leukemia: a challenge of controlling symptoms. International Journal of Pediatrics 2015;3:1145-52.
  • 45. Zorba P, Ozdemir L. The preliminary effects of massage and inhalation aromatherapy on chemotherapy-induced acute nausea and vomiting: a quasi-randomized controlled pilot trial. Cancer nursing 2018;41:359-66.
  • 46. Richardson J, Smith J, McCall G, Richardson A, Pilkington K, Kirsch I. Hypnosis for nausea and vomiting in cancer chemotherapy: a systematic review of the research evidence. European Journal of Cancer Care 2007;16:402-12.
  • 47. Zeltzer LK, Dolgin MJ, LeBaron S, LeBaron C. A randomized, controlled study of behavioral intervention for chemotherapy distress in children with cancer. Pediatrics 1991;88:34-42.
  • 48. Sadat Hoseini A. Effect of music therapy on chemotherapy nausea and vomiting in children with malignancy. Journal of hayat 2009;15:5-14.
  • 49. Sickel K, Barrett M, Siegenthaler A. The Effect of Complementary Therapies on the Treatment of Chemotherapeutic Induced Nausea and Vomiting: A Systematic Review. 2018.
  • 50. https://www.sign.ac.uk/sign-132-long-term-follow-up-of-survivors-of-childhood cancer.html

Symptom Management for Nausea-Vomiting in Children Receiving Cancer Treatment: Evidence-Based Practices

Yıl 2019, Cilt: 17 Sayı: 1, 170 - 182, 01.04.2019

Öz

Chemotherapy-induced nausea and
vomiting which require multidisciplinary approaches are among the most common
symptoms in children receiving cancer treatment. Despite advances in antiemetic
protocols, difficulties in coping with nausea and vomiting are still ongoing in
recent years. Children experiencing uncontrolled nausea and vomiting have many
problems such as prolongation of treatment, the decrease in quality of life,
fluid-electrolyte imbalance, insufficient nutrition and reduction of adaptation
to treatment. In the present review, it is aimed to provide current
evidence-based information as a guide for nurses. In addition to
pharmacological methods, integrative health approaches are preferred to reduce
nausea and vomiting. Nurses should have sufficient knowledge and skills to
ensure optimal management of nausea and vomiting. In this respect, it is
suggested that nurses should provide guidance/counseling and training on the
application of evidence-based therapies and integrative methods. Nurses who
work in the pediatric oncology/hematology units should follow the guidelines
and transfer this current evidence-based information to their practice. The
standardized and current antiemetic treatments based on chemotherapy protocols
will improve the quality of life of children and parents by preventing/reducing
the nausea-vomiting symptom experienced by children. In this review, it was
determined that the assessment tools and standard treatment methods used in the
management of nausea and vomiting were insufficient. Therefore, more experimental
and evidence-based studies on both pharmacological and integrative methods are
recommended for effective management of nausea and vomiting.

Kaynakça

  • 1. Rodgers C, Kollar D, Taylor O, et al. Nausea and vomiting perspectives among children receiving moderate to highly emetogenic chemotherapy treatment. Cancer nursing 2012;35:203-10.
  • 2. Turan SA, Esenay FI, Güven M. Symptoms in Children After Chemotherapy. Guencel Pediatri 2016;14.
  • 3. Felix‐Ukwu F, Reichert K, Bernhardt MB, Schafer ES, Berger A. Evaluation of aprepitant for acute chemotherapy‐induced nausea and vomiting in children and adolescents with acute lymphoblastic leukemia receiving high‐dose methotrexate. Pediatric blood & cancer 2018;65:e26857.
  • 4. Ruggiero A, Rizzo D, Catalano M, Coccia P, Triarico S, Attiná G. Acute chemotherapy-induced nausea and vomiting in children with cancer: Still waiting for a common consensus on treatment. Journal of International Medical Research 2018:0300060518765324.
  • 5. Velez-Florez G, Velez-Florez MC, Mantilla-Rivas JO, Patarroyo-Rodríguez L, Borrero-León R, Rodríguez-León S. Mind-Body Therapies in Childhood Cancer. Current psychiatry reports 2018;20:58.
  • 6. Yeh C-H, Chiang Y-C, Chien L-C, Lin L, Yang C-P, Chuang H-L. Symptom clustering in older Taiwanese children with cancer. Oncology nursing forum. Vol 352008.
  • 7. Çolaklar H. Evidence-Based Information Services: An Example of a Literature Review. Journal of Balkan Libraries Union 2017;5:11-20.
  • 8. Warr D. Chemotherapy-and cancer-related nausea and vomiting. Current oncology 2008;15:S4.
  • 9. Hockenberry MJ, Rodgers CC. Nausea, Vomiting, Anorexia, and Fatigue. Pediatric Psycho-Oncology: A Quick Reference on the Psychosocial Dimensions of Cancer Symptom Management 2015:79.
  • 10. Dupuis LL, Sung L, Molassiotis A, Orsey AD, Tissing W, van de Wetering M. 2016 updated MASCC/ESMO consensus recommendations: Prevention of acute chemotherapy-induced nausea and vomiting in children. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2017;25:323-31.
  • 11. Roila F, Warr D, Aapro M, et al. Delayed emesis: moderately emetogenic chemotherapy (single-day chemotherapy regimens only). Supportive Care in Cancer 2011;19:57-62.
  • 12. Herrstedt J. Antiemetics: an update and the MASCC guidelines applied in clinical practice. Nature Reviews Clinical Oncology 2008;5:32.
  • 13. Dupuis LL, Robinson PD, Boodhan S, et al. Guideline for the prevention and treatment of anticipatory nausea and vomiting due to chemotherapy in pediatric cancer patients. Pediatric blood & cancer 2014;61:1506-12.
  • 14. Flank J, Robinson PD, Holdsworth M, et al. Guideline for the Treatment of Breakthrough and the Prevention of Refractory Chemotherapy‐Induced Nausea and Vomiting in Children With Cancer. Pediatric blood & cancer 2016;63:1144-51.
  • 15. Şişman H. BARF Bulantı Ölçeği’ nin Geçerlilik ve Güvenirlik Çalışması İstanbul: T.C. Acıbadem Üniversitesi Sağlık Bilimleri Enstitüsü; 2015.
  • 16. Conk Z, Başbakkal Z, Yılmaz HB, Bolışık B. Pediatri hemşireliği. Akademisyen Tıp Kitabevi; 2013.
  • 17. Okumura LM, Rodrigues DA, Ferreira MAP, Moreira LB. Aprepitant in pediatric patients using moderate and highly emetogenic protocols: a systematic review and meta‐analyses of randomized controlled trials. British journal of clinical pharmacology 2017;83:1108-17.
  • 18. Aapro M, Gralla RJ, Herrstedt J, Molassiotis A, Roila F. MASCC/ESMO antiemetic guideline 2016. Dostęp: http://www mascc org/assets/Guidelines-Tools/mascc_antiemetic_guidelines_ english _2016_v 2016;1.
  • 19. Navari RM. 5-HT3 receptors as important mediators of nausea and vomiting due to chemotherapy. Biochimica et Biophysica Acta (BBA)-Biomembranes 2015;1848:2738-46.
  • 20. Tricco AC, Blondal E, Veroniki AA, et al. Comparative safety and effectiveness of serotonin receptor antagonists in patients undergoing chemotherapy: a systematic review and network meta-analysis. BMC medicine 2016;14:216.
  • 21. Jain S, Kapoor G, Koneru S, Vishwakarma G. A randomized, open-label non-inferiority study to compare palonosetron and ondansetron for prevention of acute chemotherapy-induced vomiting in children with cancer receiving moderate or high emetogenic chemotherapy. Supportive Care in Cancer 2018:1-7.
  • 22. Chow R, Warr DG, Navari RM, et al. Should palonosetron be a preferred 5-HT 3 receptor antagonist for chemotherapy-induced nausea and vomiting? An updated systematic review and meta-analysis. Supportive Care in Cancer 2018:1-31.
  • 23. Dupuis LL, Boodhan S, Holdsworth M, et al. Guideline for the prevention of acute nausea and vomiting due to antineoplastic medication in pediatric cancer patients. Pediatric blood & cancer 2013;60:1073-82.
  • 24. Jordan K, Roila F, Molassiotis A, Maranzano E, Clark-Snow RA, Feyer P. Antiemetics in children receiving chemotherapy. MASCC/ESMO guideline update 2009. Supportive Care in Cancer 2011;19:37-42.
  • 25. Kang HJ, Loftus S, DiCristina C, Green S, Pong A, Zwaan CM. Aprepitant for the prevention of chemotherapy‐induced nausea and vomiting in paediatric subjects: An analysis by age group. Pediatric blood & cancer 2018:e27273.
  • 26. Bakhshi S, Batra A, Biswas B, Dhawan D, Paul R, Sreenivas V. Aprepitant as an add-on therapy in children receiving highly emetogenic chemotherapy: a randomized, double-blind, placebo-controlled trial. Supportive Care in Cancer 2015;23:3229-37.
  • 27. Yuan D-M, Li Q, Zhang Q, et al. Efficacy and safety of neurokinin-1 receptor antagonists for prevention of chemotherapy-induced nausea and vomiting: systematic review and meta-analysis of randomized controlled trials. Asian Pac J Cancer Prev 2016;17:1661-75.
  • 28. Ruggiero A, Arena R, Battista A, Rizzo D, Attinà G, Riccardi R. Azole interactions with multidrug therapy in pediatric oncology. European journal of clinical pharmacology 2013;69:1-10.
  • 29. Ruggiero A, Cefalo MG, Coccia P, Mastrangelo S, Maurizi P, Riccardi R. The role of diet on the clinical pharmacology of oral antineoplastic agents. European journal of clinical pharmacology 2012;68:115-22.
  • 30. Lin MLM, Robinson PD, Flank J, Sung L, Dupuis LL. The safety of prochlorperazine in children: a systematic review and meta-analysis. Drug safety 2016;39:509-16.
  • 31. Dupuis LL, Roscoe JA, Olver I, Aapro M, Molassiotis A. 2016 updated MASCC/ESMO consensus recommendations: Anticipatory nausea and vomiting in children and adults receiving chemotherapy. Supportive care in cancer 2017;25:317-21.
  • 32. Rock EM, Sticht MA, Limebeer CL, Parker LA. Cannabinoid regulation of acute and anticipatory nausea. Cannabis and cannabinoid research 2016;1:113-21.
  • 33. Wong SS, Wilens TE. Medical cannabinoids in children and adolescents: a systematic review. Pediatrics 2017;140:e20171818.
  • 34. Uzun S, Kozumplik O, Jakovljević M, Sedić B. Side effects of treatment with benzodiazepines. Psychiatria Danubina 2010;22:90-3.
  • 35. Kreitzer MJ, Koithan M. Integrative nursing. Vol 11. Oxford University Press; 2014.
  • 36. Navari RM. Management of Chemotherapy-Induced Nausea and Vomiting in Pediatric Patients. Paediatric drugs 2017;19:213-22.
  • 37. Jacobs SS. Integrative Therapy Use for Management of Side Effects and Toxicities Experienced by Pediatric Oncology Patients. Children 2014;1:424-40.
  • 38. Momani TeG, Berry DL. Integrative therapeutic approaches for the management and control of nausea in children undergoing cancer treatment: a systematic review of literature. Journal of Pediatric Oncology Nursing 2017;34:173-84.
  • 39. McKeon C, Smith CA, Hardy J, Chang E. Acupuncture and acupressure for chemotherapy-induced nausea and vomiting: a systematic review. Australian Journal of Acupuncture and Chinese Medicine 2013;8:2.
  • 40. Jones E, Isom S, Kemper KJ, McLean TW. Acupressure for chemotherapy-associated nausea and vomiting in children. Journal of the Society for Integrative Oncology 2008;6:141-5.
  • 41. Ndao DH, Ladas EJ, Cheng B, et al. Inhalation aromatherapy in children and adolescents undergoing stem cell infusion: results of a placebo‐controlled double‐blind trial. Psycho‐Oncology 2012;21:247-54.
  • 42. Evans A, Malvar J, Garretson C, Pedroja Kolovos E, Baron Nelson M. The Use of Aromatherapy to Reduce Chemotherapy-Induced Nausea in Children With Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of Pediatric Oncology Nursing 2018:1043454218782133.
  • 43. Mazlum S, Chaharsoughi NT, Banihashem A, Vashani HB. The effect of massage therapy on chemotherapy-induced nausea and vomiting in pediatric cancer. Iranian journal of nursing and midwifery research 2013;18:280.
  • 44. Miladinia M, Baraz S, Mousavi Nouri E, Gholamzadeh Baeis M. Effects of slow-stroke back massage on chemotherapy-induced nausea and vomiting in the pediatrics with acute leukemia: a challenge of controlling symptoms. International Journal of Pediatrics 2015;3:1145-52.
  • 45. Zorba P, Ozdemir L. The preliminary effects of massage and inhalation aromatherapy on chemotherapy-induced acute nausea and vomiting: a quasi-randomized controlled pilot trial. Cancer nursing 2018;41:359-66.
  • 46. Richardson J, Smith J, McCall G, Richardson A, Pilkington K, Kirsch I. Hypnosis for nausea and vomiting in cancer chemotherapy: a systematic review of the research evidence. European Journal of Cancer Care 2007;16:402-12.
  • 47. Zeltzer LK, Dolgin MJ, LeBaron S, LeBaron C. A randomized, controlled study of behavioral intervention for chemotherapy distress in children with cancer. Pediatrics 1991;88:34-42.
  • 48. Sadat Hoseini A. Effect of music therapy on chemotherapy nausea and vomiting in children with malignancy. Journal of hayat 2009;15:5-14.
  • 49. Sickel K, Barrett M, Siegenthaler A. The Effect of Complementary Therapies on the Treatment of Chemotherapeutic Induced Nausea and Vomiting: A Systematic Review. 2018.
  • 50. https://www.sign.ac.uk/sign-132-long-term-follow-up-of-survivors-of-childhood cancer.html
Toplam 50 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Derleme
Yazarlar

Meltem Gürcan Bu kişi benim

Sevcan Atay Turan Bu kişi benim

Yayımlanma Tarihi 1 Nisan 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 17 Sayı: 1

Kaynak Göster

APA Gürcan, M., & Atay Turan, S. (2019). Kanser Tedavisi Alan Çocuklarda Bulantı-Kusmaya Yönelik Semptom Yönetimi: Kanıt Temelli Uygulamalar. Güncel Pediatri, 17(1), 170-182. https://doi.org/10.32941/pediatri.544507
AMA Gürcan M, Atay Turan S. Kanser Tedavisi Alan Çocuklarda Bulantı-Kusmaya Yönelik Semptom Yönetimi: Kanıt Temelli Uygulamalar. Güncel Pediatri. Nisan 2019;17(1):170-182. doi:10.32941/pediatri.544507
Chicago Gürcan, Meltem, ve Sevcan Atay Turan. “Kanser Tedavisi Alan Çocuklarda Bulantı-Kusmaya Yönelik Semptom Yönetimi: Kanıt Temelli Uygulamalar”. Güncel Pediatri 17, sy. 1 (Nisan 2019): 170-82. https://doi.org/10.32941/pediatri.544507.
EndNote Gürcan M, Atay Turan S (01 Nisan 2019) Kanser Tedavisi Alan Çocuklarda Bulantı-Kusmaya Yönelik Semptom Yönetimi: Kanıt Temelli Uygulamalar. Güncel Pediatri 17 1 170–182.
IEEE M. Gürcan ve S. Atay Turan, “Kanser Tedavisi Alan Çocuklarda Bulantı-Kusmaya Yönelik Semptom Yönetimi: Kanıt Temelli Uygulamalar”, Güncel Pediatri, c. 17, sy. 1, ss. 170–182, 2019, doi: 10.32941/pediatri.544507.
ISNAD Gürcan, Meltem - Atay Turan, Sevcan. “Kanser Tedavisi Alan Çocuklarda Bulantı-Kusmaya Yönelik Semptom Yönetimi: Kanıt Temelli Uygulamalar”. Güncel Pediatri 17/1 (Nisan 2019), 170-182. https://doi.org/10.32941/pediatri.544507.
JAMA Gürcan M, Atay Turan S. Kanser Tedavisi Alan Çocuklarda Bulantı-Kusmaya Yönelik Semptom Yönetimi: Kanıt Temelli Uygulamalar. Güncel Pediatri. 2019;17:170–182.
MLA Gürcan, Meltem ve Sevcan Atay Turan. “Kanser Tedavisi Alan Çocuklarda Bulantı-Kusmaya Yönelik Semptom Yönetimi: Kanıt Temelli Uygulamalar”. Güncel Pediatri, c. 17, sy. 1, 2019, ss. 170-82, doi:10.32941/pediatri.544507.
Vancouver Gürcan M, Atay Turan S. Kanser Tedavisi Alan Çocuklarda Bulantı-Kusmaya Yönelik Semptom Yönetimi: Kanıt Temelli Uygulamalar. Güncel Pediatri. 2019;17(1):170-82.