Çocukluk Çağında Hiperkalseminin Nadir Bir Nedeni Paratiroid Adenomu: Bir Olgu Sunumu ve Literatürün Gözden Geçirilmesi

Yıl 2014, Cilt: 12 Sayı: 2, 107 - 111, 01.09.2014

Ahmet Anık Gönül Çatlı Pınar Edem Özlem Bağ Ayhan Abacı Ece Böber

https://doi.org/10.4274/jcp.30602

Öz

Primer hiperparatiroidi çocuklarda çok nadir olarak görülen ve genellikle erişkin dönemde tanı konan bir hastalıktır. Paratiroid bezlerin bir veya daha fazlasında parathormon sentezinde artış sonucu ortaya çıkar. Çocuklarda görülme sıklığı 2-5/100,000 iken erişkinde bu oran 1/1000’dir. Tanı anında primer hiperparatiroidili çocukların %73-94’ünde hiperkalsemi ile ilgili semptomlar gözlenmektedir. Çocukluk çağında gerek semptomların özgül olmaması, gerekse de hastalığın erken dönemlerinde hiperkalseminin epizodik olması bu hastalarda nefrokalsinozis, nefrolitiyazis, akut pankreatit ve kemik tutulumu gibi hedef organ hasarının daha sık gözlenmesine neden olmaktadır. Tüm bu nedenlerden ötürü hastalığın erken tanınması ve etkin olarak tedavi edilmesi hedef organ hasarının engellenmesi açısından oldukça önemlidir. Bu olgu sunumunda hiperkalsemi ile ilişkili semtomları olmayan, rastlantısal olarak serum kalsiyum ve parathormon düzeyi yüksek saptanan ve hedef organ hasarı gelişmemiş paratiroid adenomlu 11 yaşında bir erkek olgu -nadir görülmesi nedeni ile- literatür bilgisi eşliğinde sunulmuştur

Anahtar Kelimeler

Hiperkalsemi, hiperparatiroidi, paratiroid adenomu

A Rare Cause of Hypercalcemia in Childhood; Parathyroid Adenoma: Case Report and Review of the Literature

Öz

Hyperparathyroidism is very rare in children incidence of 2-5 in 100 000 and occurs predominantly in adults incidence of 1 in 1000 . It is caused by increased synthesis of parathormone PTH by one or more pathologically effected parathyroid glands. HPT symptoms are usually non-specific and hypercalcemia may only be episodic in early period and these characteristics are the causes of late recognition and diagnosis of pediatric HPT which can culminate with endorgan damage. At the time of the diagnose 73-94% of PHPT cases in young patients are recognised as a symptomatic, and end-organ involvement, such as nephrocalcinosis, nephrolithiasis, acute pancreatitis, or bone involvement is not rare which is highly related to the prognosis. Therefore, early recognition and evaluation of symptoms would give a chance to prevent negative outcomes. In this case report we describe an incidentally diagnosed parathyroid adenoma in 11 year old asymptomatic male patient with no end-organ involvement

Anahtar Kelimeler

Hypercalcemia, hyperparathyroidism, parathyroid adenoma

Kaynakça

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