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Akut Generalize Ekzantematöz Püstülozis

Yıl 2013, Cilt: 11 Sayı: 2, 77 - 80, 01.09.2013
https://doi.org/10.4274/Jcp.11.77486

Öz

Akut generalize ekzantematöz püstülozis AGEP , klinik olarak ani başlayan, ateşle birlikte tüm vücutta yaygın püstüler döküntü ile seyreden nadir bir dermatozdur. Vakaların %90’nında ilaç kullanım öyküsü mevcut olmakla birlikte etyopatogenezde nadiren viral ve bakteriyel enfeksiyonlar ile civaya karşı aşırı duyarlılık reaksiyonları da suçlanmaktadır. Klinik olarak eritemli zemin üzerinde, foliküler yerleşimli olmayan, çok sayıda steril püstülle karekterizedir. Hastalığın spesifik bir tedavisi yoktur, altta yatan nedenin ortadan kaldırılması ile spontan iyileşme gözlenir. Bu makalede AGEP’in etiyolojik, klinik ve histopatolojik özellikleri gözden geçirilmiştir

Kaynakça

  • 1. Beylot C, Bioulac P, Doutre MS. Acute generalized exanthematic pustuloses (four cases). Ann Dermatol Venereol 1980;107:37- 48.
  • 2. Chaabane A, Aouam K, Gassab L, Njim L, Boughattas NA. Acute generalized exanthematous pustulosis (AGEP) induced by cefotaxime. Fundam Clin Pharmacol 2010;24:429-32.
  • 3. Freedberg IM, Eisen AZ, Wolff K, et al. Fitzpatrick’s Dermatology in General Medicine 6th ed. New York: McGraw-Hill 2003:625-7.
  • 4. Roujeau JC, Bioulac-Sage P, Bourseau C, Guillaume JC, Bernard P, Lok C, et al. Acute generalized exanthematous pustulosis. Arch Dermatol 1991;127:1333-8.
  • 5. Belhadjali H, Mandhouj S, Moussa A, Njim L, Amri M, Zakhama A, et al. Mercury-induced acute generalized exanthematous pustulosis misdiagnosed as a drugrelated case. Contact Dermatitis 2008;59:52-4.
  • 6. Trevisi P, Patrizi A, Neri I, Farina P. Toxic pustuloderma associated with azithromycin. Clin Exp Dermatol 1994;19:280-81.
  • 7. Davidovici BB, Naveh HP, Cagnano E, Halevy S; RegiSCAR Study Group. Acute generalized exanthematous pustulosis (AGEP) following intake of furosemide. Harefuah 2006;145:477-9.
  • 8. Feio AB, Apetato M, Costa MM, Sá J, Alcantâra J. Acute generalized exanthematous pustulosis due to Coxsackie B4 virus. Acta Med Port 1997;10:487-91.
  • 9. Manzano S, Guggisberg D, Hammann C, Laubscher B. Acute generalized exanthematous pustulosis: first case associated with a Chlamydia pneumoniae infection. Arch Pediatr 2006; 13:1230.
  • 10. Klein N, Hartmann M, Helmbold P, Enk A. Acute generalized exanthematous pustulosis associated with recurrent urinary tract infections. Hautarzt 2009;60:226.
  • 11. Momin SB, Del Rosso JQ, Michaels B, Mobini N. Acute generalized exanthematous pustulosis: an enigmatic drug￾induced reaction. Cutis 2009;83:291.
  • 12. Samel AD, Dellavalle RP, Mockenhaupt M, et al. Drug eruptions. www.uptodate.com. Accessed 02.01.2013.
  • 13. Wolkenstein P, Chosidow O, Fléchet ML, Robbiola O, Paul M, Dumé L, et al. Patch testing in severe cutaneous adverse drug reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis. Contact Dermatitis 1996;35:234-6.
  • 14. Halevy S, Kardaun SH, Davidovici B, Wechsler J; EuroSCAR and RegiSCAR study group. EuroSCAR and RegiSCAR study group. The spectrum of histopathological features in acute generalized exanthematous püstülosis a study of 102 cases. Br J Dermatol 2010;163:1245-52.
  • 15. Kardaun SH, Kuiper H, Fidler V, Jonkman MF. The histopathological spectrum of acute generalized exanthematous pustulosis (AGEP) and its differentiation from generalized pustular psoriasis. J Cutan Pathol 2010;37:1220-9.
  • 16. Vicente-Calleja JM, Aguirre A, Landa N, Crespo V, González￾Pérez R, Díaz-Pérez JL. Acute generalized exanthematous pustulosis due to diltiazem: confirmation by patch testing. Br. J. Dermatol 1997;137:837-9.
  • 17. Watsky K.L. Acute generalized exanthematous pustulosis induced by metronidazole: the role of patch testing. Arch. Dermatol 1999;135:93-4.
  • 18. Beylot C, Doutre MS, Beylot-Barry M. Acute generalized exanthematous pustulosis. Semin. Cutan. Med. Surg 1996;15:244-9.
  • 19. Sidoroff A, Halevy S, Bavinck JN, Vaillant L, Roujeau JC. Acute generalized exanthematous pustulosis (AGEP)- a clinical reaction pattern. J Cutan Pathol 2001;28:113-9.
  • 20. Sidoroff A, Dunant A, Viboud C, Halevy S, Bavinck JN, Naldi L, et al. Risk factors for acute generalized exanthematous pustulosis (AGEP) results of a multinational case-control study (EuroSCAR). Br J Dermatol 2007;157:989-96.
  • 21. Ozmen S, Misirlioglu ED, Gurkan A, Arda N, Bostanci I. Is acute generalized exanthematous pustulosis an uncommon condition in childhood? Allergy 2010;65:1490-2.
  • 22. Poliak N, Elias M, Cianferoni A, Treat J. Acute generalized exanthematous pustulosis: the first pediatric case caused by a contrast agent. Ann Allergy Asthma Immunol 2010;105:242-3.
  • 23. Belda Junior W, Ferolla AC. Acute generalized exanthematous pustulosis (AGEP). Case report. Rev Inst Med Trop Sao Paulo 2005;47:171-76.
  • 24. Kaya A, Yıldız S, Balkan II, Eyvazov H, Bavunoglu I, Mert A. Acute generalized exanthematous pustulosis after ceftriaxone use resembling sepsis. J Infect Chemother 2012;18:112-4.
  • 25. Cohen AD, Cagnano E, Halevy S. Acute generalized exanthematous pustulosis mimicking toxic epidermal necrolysis. Int J Dermatol 2001;40:458-61.
  • 26. Fernando SL. Acute generalised exanthematous pustulosis. Australasian Journal of Dermatology 2012;53:87-92.

Acute Generalized Exanthematous Pustulosis

Yıl 2013, Cilt: 11 Sayı: 2, 77 - 80, 01.09.2013
https://doi.org/10.4274/Jcp.11.77486

Öz

Acute generalized exanthematous pustulosis AGEP is a rare cutaneous rash characterized by the abrupt onset of a widespread generalized pustular rash often accompanied by fever. In the etiopathogenesis, there is a history of drug use in 90% of the cases, and occasionally hypersensitivity reactions to mercury or viral and bacterial infections are accused. Nonfollicular eruptions on a erythematous surface spreading on a large scale are clinical features. There is no specific treatment when underlying cause cured spontaneous healing occures. AGEP’s etiology clinical and histopathologic characteristics are reviewed here

Kaynakça

  • 1. Beylot C, Bioulac P, Doutre MS. Acute generalized exanthematic pustuloses (four cases). Ann Dermatol Venereol 1980;107:37- 48.
  • 2. Chaabane A, Aouam K, Gassab L, Njim L, Boughattas NA. Acute generalized exanthematous pustulosis (AGEP) induced by cefotaxime. Fundam Clin Pharmacol 2010;24:429-32.
  • 3. Freedberg IM, Eisen AZ, Wolff K, et al. Fitzpatrick’s Dermatology in General Medicine 6th ed. New York: McGraw-Hill 2003:625-7.
  • 4. Roujeau JC, Bioulac-Sage P, Bourseau C, Guillaume JC, Bernard P, Lok C, et al. Acute generalized exanthematous pustulosis. Arch Dermatol 1991;127:1333-8.
  • 5. Belhadjali H, Mandhouj S, Moussa A, Njim L, Amri M, Zakhama A, et al. Mercury-induced acute generalized exanthematous pustulosis misdiagnosed as a drugrelated case. Contact Dermatitis 2008;59:52-4.
  • 6. Trevisi P, Patrizi A, Neri I, Farina P. Toxic pustuloderma associated with azithromycin. Clin Exp Dermatol 1994;19:280-81.
  • 7. Davidovici BB, Naveh HP, Cagnano E, Halevy S; RegiSCAR Study Group. Acute generalized exanthematous pustulosis (AGEP) following intake of furosemide. Harefuah 2006;145:477-9.
  • 8. Feio AB, Apetato M, Costa MM, Sá J, Alcantâra J. Acute generalized exanthematous pustulosis due to Coxsackie B4 virus. Acta Med Port 1997;10:487-91.
  • 9. Manzano S, Guggisberg D, Hammann C, Laubscher B. Acute generalized exanthematous pustulosis: first case associated with a Chlamydia pneumoniae infection. Arch Pediatr 2006; 13:1230.
  • 10. Klein N, Hartmann M, Helmbold P, Enk A. Acute generalized exanthematous pustulosis associated with recurrent urinary tract infections. Hautarzt 2009;60:226.
  • 11. Momin SB, Del Rosso JQ, Michaels B, Mobini N. Acute generalized exanthematous pustulosis: an enigmatic drug￾induced reaction. Cutis 2009;83:291.
  • 12. Samel AD, Dellavalle RP, Mockenhaupt M, et al. Drug eruptions. www.uptodate.com. Accessed 02.01.2013.
  • 13. Wolkenstein P, Chosidow O, Fléchet ML, Robbiola O, Paul M, Dumé L, et al. Patch testing in severe cutaneous adverse drug reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis. Contact Dermatitis 1996;35:234-6.
  • 14. Halevy S, Kardaun SH, Davidovici B, Wechsler J; EuroSCAR and RegiSCAR study group. EuroSCAR and RegiSCAR study group. The spectrum of histopathological features in acute generalized exanthematous püstülosis a study of 102 cases. Br J Dermatol 2010;163:1245-52.
  • 15. Kardaun SH, Kuiper H, Fidler V, Jonkman MF. The histopathological spectrum of acute generalized exanthematous pustulosis (AGEP) and its differentiation from generalized pustular psoriasis. J Cutan Pathol 2010;37:1220-9.
  • 16. Vicente-Calleja JM, Aguirre A, Landa N, Crespo V, González￾Pérez R, Díaz-Pérez JL. Acute generalized exanthematous pustulosis due to diltiazem: confirmation by patch testing. Br. J. Dermatol 1997;137:837-9.
  • 17. Watsky K.L. Acute generalized exanthematous pustulosis induced by metronidazole: the role of patch testing. Arch. Dermatol 1999;135:93-4.
  • 18. Beylot C, Doutre MS, Beylot-Barry M. Acute generalized exanthematous pustulosis. Semin. Cutan. Med. Surg 1996;15:244-9.
  • 19. Sidoroff A, Halevy S, Bavinck JN, Vaillant L, Roujeau JC. Acute generalized exanthematous pustulosis (AGEP)- a clinical reaction pattern. J Cutan Pathol 2001;28:113-9.
  • 20. Sidoroff A, Dunant A, Viboud C, Halevy S, Bavinck JN, Naldi L, et al. Risk factors for acute generalized exanthematous pustulosis (AGEP) results of a multinational case-control study (EuroSCAR). Br J Dermatol 2007;157:989-96.
  • 21. Ozmen S, Misirlioglu ED, Gurkan A, Arda N, Bostanci I. Is acute generalized exanthematous pustulosis an uncommon condition in childhood? Allergy 2010;65:1490-2.
  • 22. Poliak N, Elias M, Cianferoni A, Treat J. Acute generalized exanthematous pustulosis: the first pediatric case caused by a contrast agent. Ann Allergy Asthma Immunol 2010;105:242-3.
  • 23. Belda Junior W, Ferolla AC. Acute generalized exanthematous pustulosis (AGEP). Case report. Rev Inst Med Trop Sao Paulo 2005;47:171-76.
  • 24. Kaya A, Yıldız S, Balkan II, Eyvazov H, Bavunoglu I, Mert A. Acute generalized exanthematous pustulosis after ceftriaxone use resembling sepsis. J Infect Chemother 2012;18:112-4.
  • 25. Cohen AD, Cagnano E, Halevy S. Acute generalized exanthematous pustulosis mimicking toxic epidermal necrolysis. Int J Dermatol 2001;40:458-61.
  • 26. Fernando SL. Acute generalised exanthematous pustulosis. Australasian Journal of Dermatology 2012;53:87-92.
Toplam 26 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Collection
Yazarlar

Hikmet Tekin Nacaroğlu Bu kişi benim

Demet Can Bu kişi benim

Yayımlanma Tarihi 1 Eylül 2013
Yayımlandığı Sayı Yıl 2013 Cilt: 11 Sayı: 2

Kaynak Göster

APA Nacaroğlu, H. . T., & Can, D. (2013). Akut Generalize Ekzantematöz Püstülozis. Güncel Pediatri, 11(2), 77-80. https://doi.org/10.4274/Jcp.11.77486
AMA Nacaroğlu HT, Can D. Akut Generalize Ekzantematöz Püstülozis. Güncel Pediatri. Eylül 2013;11(2):77-80. doi:10.4274/Jcp.11.77486
Chicago Nacaroğlu, Hikmet Tekin, ve Demet Can. “Akut Generalize Ekzantematöz Püstülozis”. Güncel Pediatri 11, sy. 2 (Eylül 2013): 77-80. https://doi.org/10.4274/Jcp.11.77486.
EndNote Nacaroğlu HT, Can D (01 Eylül 2013) Akut Generalize Ekzantematöz Püstülozis. Güncel Pediatri 11 2 77–80.
IEEE H. . T. Nacaroğlu ve D. Can, “Akut Generalize Ekzantematöz Püstülozis”, Güncel Pediatri, c. 11, sy. 2, ss. 77–80, 2013, doi: 10.4274/Jcp.11.77486.
ISNAD Nacaroğlu, Hikmet Tekin - Can, Demet. “Akut Generalize Ekzantematöz Püstülozis”. Güncel Pediatri 11/2 (Eylül 2013), 77-80. https://doi.org/10.4274/Jcp.11.77486.
JAMA Nacaroğlu HT, Can D. Akut Generalize Ekzantematöz Püstülozis. Güncel Pediatri. 2013;11:77–80.
MLA Nacaroğlu, Hikmet Tekin ve Demet Can. “Akut Generalize Ekzantematöz Püstülozis”. Güncel Pediatri, c. 11, sy. 2, 2013, ss. 77-80, doi:10.4274/Jcp.11.77486.
Vancouver Nacaroğlu HT, Can D. Akut Generalize Ekzantematöz Püstülozis. Güncel Pediatri. 2013;11(2):77-80.