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İdiyopatik Epilepsi Tanısı ile İzlenen Hastalarda Epilepsi ile Karışan Kardiak veya Vazovagal Senkop Sıklığı

Yıl 2011, Cilt: 9 Sayı: 1, 94 - 99, 01.06.2011

Öz

Giriş: Epilepsi tanısı; geçici şuur kaybının klinik bulguları, aile öyküsü ve elektroensefalografi bulguları birleştirilerek konulur. Epilepsi tanısı ile izlenen hastalardaki yanlış tanıoranının %5-31,8 arasında değiştiği bilinmektedir. Epilepsi yanlış tanısı konulmasının nedenleri, hikâyenin eksik ve dikkatsiz alınması, ailede epilepsi öyküsü olması, özgeçmişinde febril konvülziyon öyküsünün olması, elektroensefalografik patolojik bulgularınvarlığının klinik bulguların önüne geçmesi olarak sıralanabilir. Epilepsinin en fazla karıştığı klinik tanı vazovagal senkoptur. Ayrıca kardiyak nedenlerle meydana gelen senkoplar da yanlışlıkla epilepsi tanısı alabilmektedir. Gereç ve Yöntem: Çalışmaya daha önce epilepsi tanısı alan 119 çocuk dahil edildi. Hastaların %62,1’i 74/119 erkekti ve yaş ortalaması 9,35 yıl idi. Tüm hastaların nöbetözellikleri ve aile öyküleri yeniden sorgulandı ve muayeneleri yapıldı. Tüm hastalaraelektrokardiyografik değerlendirme ve 109 hastaya ekokardiyografik çalışma yapıldı. İhtiyaç duyulduğunda head-up tilt testi, 24 saatlik Holter elektrokardiyografi incelemesive efor testi yapıldı. Bulgular: Geçici şuur kaybına neden olabilecek yapısal kardiyak problem veya aritmihiçbir hastada saptanmadı. Toplam 3 hastada vazovagal senkop saptandı %2,5 . Buhastalar yanlış olarak epilepsi tanısıyla takip edilmekteydiler. Sonuç: Vazovagal senkoplu bazı hastalar yanlışlıkla epilepsi olarak takip edilebilirler. Hikâye alınırken gösterilecek daha fazla dikkat, elektroensefalografi ve tilt testi sonuçlarının klinik bulgular göz önüne alınarak daha dikkatlice değerlendirilmesi, yanlış tanıoranlarını azaltabilir

Kaynakça

  • 1. Stroink H, Van Donselaar CA, Geerts AT, Peters AC, Brouwe OF, Arts WF. The accuracy of the diagnosis of paroxysmal events in children. Neurolog 2003;60:979-82.
  • 2. S RJ, S PC, Thomas JM, G S. Thomas Sudarsana G. Congenital long QT syndrome presenting as epilepsy. Indian Pediatrics 2003;40:1201-3.
  • 3. Medina-Villanueva A, Rey-Galan C, Concha-Torre A, Gutierrez-Martinez JR. Long QT syndrome presented as epilepsy. Rev Neurol 2002;35:346-8.
  • 4. Yuksel H, Baflkurt M, Çeliker C, Türkoğlu C, Yazıcıoğlu N. [Congenital Long QT Syndrome in Relation to a Case Report]. Türk Kardiyol Dern Arfl 2002;30:49-53.
  • 5. Brodie MJ, Shorvon SD, Canger R, Halasz P, Johannessen S, Thompson P et al. ILAE Commission report, Commission on European Affairs: Appropriate standarts of epilepsy care across Europe. Epilepsia 1997;38:1245-50.
  • 6. Bazett H. Analysis of the time relations of electrocardiograms. Heart 1920;7:353-70.
  • 7. Massin MM, Malekzadeh-Milani S, Benatar A. Cardiac syncope in pediatric patients. Clin Cardiol 2007;30:81-5.
  • 8. O’Callaghan CA, Trump D. Prolonged QT syndrome presenting as epilepsy. Lancet 1993;341:759-60.
  • 9. Sabri MR, Mahmodian T, Sadri H. Usefulness of the Head-Up Tilt Test in Distinguishing Neurally Mediated Syncope and Epilepsy in Children Aged 5-20 Years Old. Pediatr Cardiol 2006;27:600-3.
  • 10. Petkar S, Cooper P, Fitzpatrick AP. How to avoid a misdiagnosis in patients presenting with transient loss of consciousness. Postgrad Med J 2006;82:630-41.
  • 11. Zaidi A, Clough P, Cooper P, Scheepers B, Fitzpatrick AP. Misdiagnosis of epilepsy: many seizure-like attacks have a cardiovascular cause. J Am Coll Cardiol 2000;36:181-4.
  • 12. Erdogan O. Diagnosis and management of vasovagal syncope. Turkiye Klinikleri J Cardiol 2001;14:184-9.
  • 13. Wolfe DA, Grubb BP, Kimmel SR. Head-upright tilt test: A new method of evaluating syncope. Am Family Physician 1993;47:149-59.
  • 14. David A. Lewis, MD and Answer Dhala, MD. Syncope In the pediatric patient. Pediatr Clin North Am 1999;46:205-19.
  • 15. Kowacs PA, Silva Júnior EB, Santos HL, Rocha SB, Simão C, Meneses MS et al. Syncope or epileptic fits? Some examples of diagnostic confounding factors. Arq Neuropsiquiatr 2005;63:597-600.
  • 16. Engel J. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 1989;30:389-99.
  • 17. Park MK. Syncope. In: Park MK, ed. Pediatric Cardiology for Practitioners. 5th ed, Philadelphia: Mosby 2008. p.508-17.
  • 18. Sheldon R, Rose S, Ritchie D, Connolly SJ, Koshman ML, Lee MA, et al. Historical criteria that distinguish syncope from seizures. J Am Coll Cardiol 2002;40:142-8.
  • 19. Moss AJ, Schwartz PJ, Crampton RS, Tzivoni D, Locati EH, MacCluer J et al. The long QT syndrome. Prospective longitudinal study of 328 families. Circulation 1991;84:1136-44.
  • 20. Johnson JN, Hofman N, Haglung CM, Cascino GD, Wilde AA, Ackerman MJ. Identification long QT syndrome and epilepsy. Neurology 2009;72:224-31.
  • 21. Akhtar MJ. All seizures are not epilepsy; many have a cardiovascular cause. J Pak Med Assoc 2002;52:116-20.
  • 22. Woodley D, Chambers W, Starke H, Dzindzio B, Forker AD. Intermittent complete atrioventricular block masquerading as epilepsy in the mitral valve prolapse syndrome. Chest 1977;72:369-72.
  • 23. Zarraga IG, Ware DL. Syncope, seizure, or both? An unusual case of complete heart block. J Electrocardiol 2007;40:493-5.
  • 24. Turanli G, Apak RA. Cardiac dysrhythmia that simulates seizure disorder in two children. Turk J Pediatr 1999;41:521-3.
  • 25. Ballardie FW, Murphy RP, Davis J. Epilepsy: a presentation of the Romano-Ward syndrome. Br Med J (Clin Res Ed) 1983;287:896-7.
  • 26. Ferrie CD. Preventing misdiagnosis of epilepsy. Arch Dis Child 2006;91:206-9

Cardiac or Vasovagal Syncope Misdiagnosed as Idiopathic Epilepsy

Yıl 2011, Cilt: 9 Sayı: 1, 94 - 99, 01.06.2011

Öz

Introduction: Epilepsy is diagnosed by combining the clinical features of the temporaryloss of consciousness, family history and electroencephalography. False diagnosis rateamong patients with epilepsy is reported between 5% and 31.5%. Possible reasons offalse diagnosis are; carelessly taken history, presence of family members with epilepsy,presence of previous febrile convulsions, and to give preference to the pathologic electroencephalographic findings. The most common problem that is misdiagnosed asepilepsy is vasovagal syncope. In addition cardiac reasons can be misdiagnosed as epilepsy. In the present study, we aimed to evaluate the frequency of vasovagal and cardiovascular syncope among children with a diagnosis of idiopathic epilepsy. Materials and Method: A total of 119 children with a previous diagnosis of epilepsiwere included in the study. The 62.1% 74/119 of the patients were male, and the meanage was 9.35 years. All patients were reevaluated in terms of the features of their seizures and the family history. Then they were examined. A standard electrocardiographywas obtained in all and echocardiography in 109 patients. Head-up tilt table test, 24-hourelectrocardiography and treadmill tests were performed when needed. Results: No constitutional cardiac problem or arrhythmia was detected as a cause of temporary loss of consciousness. Vasovagal syncope was diagnosed in 3 patients 2.5% . They were being followed with a false epilepsy diagnosis.Conclusions: Some patients with vasovagal syncope can be misdiagnosed as epilepsy. More attention to history taking and

Kaynakça

  • 1. Stroink H, Van Donselaar CA, Geerts AT, Peters AC, Brouwe OF, Arts WF. The accuracy of the diagnosis of paroxysmal events in children. Neurolog 2003;60:979-82.
  • 2. S RJ, S PC, Thomas JM, G S. Thomas Sudarsana G. Congenital long QT syndrome presenting as epilepsy. Indian Pediatrics 2003;40:1201-3.
  • 3. Medina-Villanueva A, Rey-Galan C, Concha-Torre A, Gutierrez-Martinez JR. Long QT syndrome presented as epilepsy. Rev Neurol 2002;35:346-8.
  • 4. Yuksel H, Baflkurt M, Çeliker C, Türkoğlu C, Yazıcıoğlu N. [Congenital Long QT Syndrome in Relation to a Case Report]. Türk Kardiyol Dern Arfl 2002;30:49-53.
  • 5. Brodie MJ, Shorvon SD, Canger R, Halasz P, Johannessen S, Thompson P et al. ILAE Commission report, Commission on European Affairs: Appropriate standarts of epilepsy care across Europe. Epilepsia 1997;38:1245-50.
  • 6. Bazett H. Analysis of the time relations of electrocardiograms. Heart 1920;7:353-70.
  • 7. Massin MM, Malekzadeh-Milani S, Benatar A. Cardiac syncope in pediatric patients. Clin Cardiol 2007;30:81-5.
  • 8. O’Callaghan CA, Trump D. Prolonged QT syndrome presenting as epilepsy. Lancet 1993;341:759-60.
  • 9. Sabri MR, Mahmodian T, Sadri H. Usefulness of the Head-Up Tilt Test in Distinguishing Neurally Mediated Syncope and Epilepsy in Children Aged 5-20 Years Old. Pediatr Cardiol 2006;27:600-3.
  • 10. Petkar S, Cooper P, Fitzpatrick AP. How to avoid a misdiagnosis in patients presenting with transient loss of consciousness. Postgrad Med J 2006;82:630-41.
  • 11. Zaidi A, Clough P, Cooper P, Scheepers B, Fitzpatrick AP. Misdiagnosis of epilepsy: many seizure-like attacks have a cardiovascular cause. J Am Coll Cardiol 2000;36:181-4.
  • 12. Erdogan O. Diagnosis and management of vasovagal syncope. Turkiye Klinikleri J Cardiol 2001;14:184-9.
  • 13. Wolfe DA, Grubb BP, Kimmel SR. Head-upright tilt test: A new method of evaluating syncope. Am Family Physician 1993;47:149-59.
  • 14. David A. Lewis, MD and Answer Dhala, MD. Syncope In the pediatric patient. Pediatr Clin North Am 1999;46:205-19.
  • 15. Kowacs PA, Silva Júnior EB, Santos HL, Rocha SB, Simão C, Meneses MS et al. Syncope or epileptic fits? Some examples of diagnostic confounding factors. Arq Neuropsiquiatr 2005;63:597-600.
  • 16. Engel J. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 1989;30:389-99.
  • 17. Park MK. Syncope. In: Park MK, ed. Pediatric Cardiology for Practitioners. 5th ed, Philadelphia: Mosby 2008. p.508-17.
  • 18. Sheldon R, Rose S, Ritchie D, Connolly SJ, Koshman ML, Lee MA, et al. Historical criteria that distinguish syncope from seizures. J Am Coll Cardiol 2002;40:142-8.
  • 19. Moss AJ, Schwartz PJ, Crampton RS, Tzivoni D, Locati EH, MacCluer J et al. The long QT syndrome. Prospective longitudinal study of 328 families. Circulation 1991;84:1136-44.
  • 20. Johnson JN, Hofman N, Haglung CM, Cascino GD, Wilde AA, Ackerman MJ. Identification long QT syndrome and epilepsy. Neurology 2009;72:224-31.
  • 21. Akhtar MJ. All seizures are not epilepsy; many have a cardiovascular cause. J Pak Med Assoc 2002;52:116-20.
  • 22. Woodley D, Chambers W, Starke H, Dzindzio B, Forker AD. Intermittent complete atrioventricular block masquerading as epilepsy in the mitral valve prolapse syndrome. Chest 1977;72:369-72.
  • 23. Zarraga IG, Ware DL. Syncope, seizure, or both? An unusual case of complete heart block. J Electrocardiol 2007;40:493-5.
  • 24. Turanli G, Apak RA. Cardiac dysrhythmia that simulates seizure disorder in two children. Turk J Pediatr 1999;41:521-3.
  • 25. Ballardie FW, Murphy RP, Davis J. Epilepsy: a presentation of the Romano-Ward syndrome. Br Med J (Clin Res Ed) 1983;287:896-7.
  • 26. Ferrie CD. Preventing misdiagnosis of epilepsy. Arch Dis Child 2006;91:206-9
Toplam 26 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Research Article
Yazarlar

Mehmet Karacan

Duygu Bidev Bu kişi benim

Haşim Olgun Bu kişi benim

Hüseyin Tan Bu kişi benim

Naci Ceviz Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2011
Yayımlandığı Sayı Yıl 2011 Cilt: 9 Sayı: 1

Kaynak Göster

APA Karacan, M., Bidev, D., Olgun, H., Tan, H., vd. (2011). İdiyopatik Epilepsi Tanısı ile İzlenen Hastalarda Epilepsi ile Karışan Kardiak veya Vazovagal Senkop Sıklığı. Güncel Pediatri, 9(1), 94-99.
AMA Karacan M, Bidev D, Olgun H, Tan H, Ceviz N. İdiyopatik Epilepsi Tanısı ile İzlenen Hastalarda Epilepsi ile Karışan Kardiak veya Vazovagal Senkop Sıklığı. Güncel Pediatri. Haziran 2011;9(1):94-99.
Chicago Karacan, Mehmet, Duygu Bidev, Haşim Olgun, Hüseyin Tan, ve Naci Ceviz. “İdiyopatik Epilepsi Tanısı Ile İzlenen Hastalarda Epilepsi Ile Karışan Kardiak Veya Vazovagal Senkop Sıklığı”. Güncel Pediatri 9, sy. 1 (Haziran 2011): 94-99.
EndNote Karacan M, Bidev D, Olgun H, Tan H, Ceviz N (01 Haziran 2011) İdiyopatik Epilepsi Tanısı ile İzlenen Hastalarda Epilepsi ile Karışan Kardiak veya Vazovagal Senkop Sıklığı. Güncel Pediatri 9 1 94–99.
IEEE M. Karacan, D. Bidev, H. Olgun, H. Tan, ve N. Ceviz, “İdiyopatik Epilepsi Tanısı ile İzlenen Hastalarda Epilepsi ile Karışan Kardiak veya Vazovagal Senkop Sıklığı”, Güncel Pediatri, c. 9, sy. 1, ss. 94–99, 2011.
ISNAD Karacan, Mehmet vd. “İdiyopatik Epilepsi Tanısı Ile İzlenen Hastalarda Epilepsi Ile Karışan Kardiak Veya Vazovagal Senkop Sıklığı”. Güncel Pediatri 9/1 (Haziran 2011), 94-99.
JAMA Karacan M, Bidev D, Olgun H, Tan H, Ceviz N. İdiyopatik Epilepsi Tanısı ile İzlenen Hastalarda Epilepsi ile Karışan Kardiak veya Vazovagal Senkop Sıklığı. Güncel Pediatri. 2011;9:94–99.
MLA Karacan, Mehmet vd. “İdiyopatik Epilepsi Tanısı Ile İzlenen Hastalarda Epilepsi Ile Karışan Kardiak Veya Vazovagal Senkop Sıklığı”. Güncel Pediatri, c. 9, sy. 1, 2011, ss. 94-99.
Vancouver Karacan M, Bidev D, Olgun H, Tan H, Ceviz N. İdiyopatik Epilepsi Tanısı ile İzlenen Hastalarda Epilepsi ile Karışan Kardiak veya Vazovagal Senkop Sıklığı. Güncel Pediatri. 2011;9(1):94-9.