Mechanisms of Allergic Inflammation

Yıl 2009, Cilt: 7 Sayı: 2, 24 - 30, 01.09.2009

Mübeccel Akdiş

Öz

Genetik yatkınlık ve çevreden gelen uyarılar T hücrelerinin, diğer inflamatuvar hücrelerin ve vücut dokularında bulunan hücrelerin yaşam sürelerini veefektör fonksiyonlarını düzenlerler. T hücrelerindeki apoptoz ve periferal tolerans bozuklukları farklı alerjik fenotiplerini belirler. Yüksek IFN-γ yapanaktive olmuş alerjen spesifik T hücreleri dolaşımda erken apoptoza gittikleriiçin atopik hastalıklarda immun yanıtı Th2 hücreleri yönüne çevirirler.Etkilenen dokularda bu hücreler efektör sitokinleri devreye sokarak epitelhücrelerinin aktivasyonunu ve apoptozunu da tetiklerler. Diğer taraftanmonoallerjik nonatopik bireylerde T regulatuvar 1 hücreleri yerine alerjenspesifik Th2 hücreleri yönüne kaymış olan denge T hücre yanıtını belirler

Anahtar Kelimeler

Apoptoz, atopi, sitokinler, T hücreleri, astım, atopik dermatit

Mechanisms of Allergic Inflammation

Öz

Genetic predisposition and environmental instructions tune thresholds for activation, effector functions and life span of T cells, other inflammatory cells and resident tissue cells. Defects in apoptosis and peripheral tolerance in T cells definedifferent allergic phenotypes. High IFN-γ-producing activated allergen-specific Tcells predominantly undergo apoptosis in the circulation, skewing the immuneresponse to surviving Th2 cells in atopic diseases. In affected tissues, these cellsswitch on effector cytokines, induce activation and apoptosis of epithelial cells.On the other hand, in monoallergic non-atopic individuals disturbed balancetoward allergen-specific T helper 2 cells instead of T regulatory 1 cells characterize the T cell response

Anahtar Kelimeler

Apoptosis, atopy, cytokines, T cells, asthma, atopic dermatitis

Kaynakça

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