Çocukluk Çağında Digoksin İntoksikasyonu: 12 Vakanın Retrospektif İncelenmesi - Orijinal Araştırma

Yıl 2007, Cilt: 5 Sayı: 3, 87 - 91, 01.12.2007

Haşim Olgun Mehmet Karacan Naci Ceviz

Öz

Digoksin terapötik penceresinin dar olması nedeniyle toksik bir ilaçtır. Bu nedenle dijitalize hastalarda %35’lere varan oranda intoksikasyonun bildirilmiş olması şaşırtıcı değildir. Dijital intoksikasyonunun iki major nedeni vardır; tedavi amacıyladigoksin alımı ve kaza ile yüksek doz digoksin alımı. Bu çalışmada 1998-2007 yılları arasında 12 digoksin intoksikasyonlu hastaretrospektif olarak incelendi. Hastaların intoksikasyon nedenleri, klinik bulguları, EKG özellikleri, kan digoksin düzeyleri sunuldu. Digoksin intoksikasyonunun önemi, tedavide yapılması gerekenler vurgulandı

Anahtar Kelimeler

Digoksin toksisitesi, çocuk

Digoxin Toxicity In Childhood: Report of 12 Cases

Öz

Digoxin is a toxic drug with a narrow therapeutic window. In view of this it is perhaps not surprising that toxicity is a common occurence, being reported in up to 35% of digitalized patients. The major causes of digitalis toxicity in infants and children are therapeutic administration and acute accidental overdose. In this retrospective study, we evaluate 11 patientswith digoxin toxicity during 1998-2007. The cause of patient's intoxication, clinical observations, ECG features and blooddigoxin levels are presented. The significance of digoxin intoxication and its treatment options are discussed

Anahtar Kelimeler

Digoxin toxicity, childhood

Kaynakça

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