False Memories in Depression and Anxiety Disorders: Cognitive Mechanisms and Experimental Findings

Öz

Major depression and anxiety disorders are characterized by negative moods that are prolonged, intense, and persistent compared to transient, experimentally induced, or self-reported mood changes. The mood-congruent memory effect has been extensively demonstrated in studies involving individuals with depression and anxiety disorders. However, the effect of mood-congruent false memories has been investigated in fewer studies. This review examines the mechanisms underlying false memories in depression and anxiety disorders using the Deese-Roediger-McDermott (DRM) paradigm and critically discusses current empirical findings. Available evidence indicates that the mood-congruent false memory effect is frequently observed in depression, whereas this effect appears to be more limited in anxiety disorders. Cognitive biases or heightened activation levels toward mood-congruent information (particularly concepts related to depression or threat) in these disorders may impair cognitive control processes or hinder effective monitoring, consequently increasing susceptibility to false memories. Furthermore, existing studies suggest that backward associative strength, resting activation levels, expertise, or salience may modulate the activation of negative (depression-related) information in depressive individuals. Finally, this review evaluates the literature within the theoretical framework of false memory formation, addresses methodological limitations, and provides recommendations for future research.

Anahtar Kelimeler

• depression
• anxiety
• mood-congruent memory
• false memory

Depresyon ve Anksiyete Bozukluklarında Bellek Yanılmaları: Bilişsel Mekanizmalar ve Deneysel Bulgular

Öz

Majör depresyon ve anksiyete bozuklukları, negatif duygudurumun öznel bildirime dayalı veya deneysel değişimleme ile geçici olarak oluşturulan gruplara göre daha uzun süreli, yoğun ve kalıcı olduğu bozukluklardır. Duygudurum uyumlu bellek etkisi, hem depresyon hem de anksiyete bozukluğu olguları ile yürütülen çalışmalarda birçok kez gösterilmiştir. Buna karşın, duygudurum uyumlu bellek yanılması etkisi daha az sayıda çalışmada incelenmiştir. Bu derlemede, Deese-Roediger-McDermott (DRM) paradigması ile depresyon ve anksiyete bozukluklarında bellek yanılmalarının oluşum mekanizmaları incelenmiş ve mevcut bulgular tartışılmıştır. Bulgular, duygudurum uyumlu bellek yanılması etkisinin depresyonda sıklıkla gözlendiğini, anksiyete bozukluklarında ise bu etkinin daha sınırlı olduğunu ortaya koymuştur. Depresyon ve anksiyete bozukluklarında, duygudurum (özellikle depresyon veya tehdit ile ilişkili kavramlar) ile uyumlu bilgilere yönelik bilişsel yanlılıklar veya yüksek aktivasyon seviyelerinin, bu bilgiler için bilişsel kontrolün veya izlemenin zorlaşmasına ve dolayısıyla bellek yanılmasına neden olabileceği değerlendirilmiştir. Bunun yanı sıra, çalışmalar depresyon olgularında negatif (depresyon ile ilişkili) bilgilere yönelik aktivasyon sürecine; geriye dönük çağrışım gücü, dinlenim aktivasyon seviyeleri, uzmanlık veya belirginlik gibi faktörlerin etki edebileceğine işaret etmektedir. Bu derleme, bellek yanılması teorileri bağlamında mevcut alanyazını ele almakta, yöntemsel sınırlılıklara dikkat çekmekte ve gelecekteki araştırmalar için öneriler sunmaktadır.

Anahtar Kelimeler

• depresyon
• duygudurum uyumlu bellek
• bellek yanılması
• anksiyete

Kaynakça

1. Alho L, Rodrigues PF, Fidalgo C (2019) Do stress and anxiety impact memory? An exploratory Portuguese study. J Psychol Res, 1:31-38.
2. Alloy LB, Abramson LY (1979) Judgment of contingency in depressed and nondepressed students: Sadder but wiser?. J Exp Psychol Gen, 108:441-485.
3. APA (2013) Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5). Washington DC, American Psychiatric Association.
4. Arkes HR, Herren LT, Isen AM (1998) The role of potential loss in the influence of affect on risk taking behavior. Organ Behav Hum Decis Process, 42:181-193.
5. Baird RR (2003) Experts sometimes show more false recall than novices: A cost of knowing too much. Learn Individ Differ, 13:349-355.
6. Bar-Haim Y, Dan O, Eshel Y, Sagi-Schwartz A (2007) Predicting children's anxiety from early attachment relationships. J Anxiety Disord, 21:1061-1068.
7. Baxter AJ, Scott KM, Vos T, Whiteford HA (2013) Global prevalence of anxiety disorders: a systematic review and meta-regression. Psychol Med, 43:897-910.
8. Beck AT (1976) Cognitive therapy and the emotional disorders. New York, International Universities Press.

9. Bernstein DM, Loftus EF (2009) The consequences of false memories for food preferences and choices. Perspect Psychol Sci, 4:135-139.
10. Blaney PH (1986) Affect and memory: a review. Psychol Bull, 99:229–246.
11. Bradley BP, Mogg K, Williams R (1995) Implicit and explicit memory for emotion-congruent information in clinical depression and anxiety. Behav Res Ther, 33:755-770.
12. Brainerd CJ, Reyna VF (2002) Fuzzy-trace theory and false memory. Curr Dir Psychol Sci, 11:164-169.
13. Brainerd CJ, Stein LM, Silveira RA, Rohenkohl G, Reyna VF (2008) How does negative emotion cause false memories?. Psychol Sci, 19:919-925.
14. Brainerd CJ, Holliday RE, Reyna VF, Yang Y, Toglia MP (2010) Developmental reversals in false memory: Effects of emotional valence and arousal. J Exp Child Psychol, 107:137-154.
15. Brenes GA (2007) Anxiety, depression, and quality of life in primary care patients. Prim Care Companion J Clin Psychiatry, 9:437-443.
16. Brennen T, Dybdahl R, Kapidžić A (2007) Trauma-related and neutral false memories in war-induced posttraumatic stress disorder. Conscious Cogn, 16:877-885.
17. Bookbinder SH, Brainerd CJ (2016) Emotion and false memory: The context–content paradox. Psychol Bull, 142:1315-1351.
18. Bower GH (1981) Mood and memory. Am Psychol, 36:129-148.
19. Calvillo DP, Parong JA (2016) The misinformation effect is unrelated to the DRM effect with and without a DRM warning. Memory, 24:324-333.
20. Castel AD, McCabe DP, Roediger HL, Heitman JL (2007) The dark side of expertise: Domain-specific memory errors. Psychol Sci, 18:3-5.
21. Charles ST, Mather M, Carstensen LL (2003) Aging and emotional memory: the forgettable nature of negative images for older adults. J Exp Psychol Gen, 132:310-324.
22. Christianson SA (1992) Emotional stress and eyewitness memory: a critical review. Psychol Bull, 112:284-309.
23. Cisler JM, Koster EH (2010) Mechanisms of attentional biases towards threat in anxiety disorders: an integrative review. Clin Psychol Rev, 30:203-216.
24. Cloitre M, Cancienne J, Heimberg RG, Holt CS, Liebowitz M (1995). Memory bias does not generalize across anxiety disorders. Behav Res Ther, 33:305-307.
25. Cody MW, Steinman SA, Teachman BA (2015) True and false memories in social anxiety disorder: effects of speech anticipation and social content. Cogn Ther Res, 39:797-807.
26. Coles ME, Heimberg RG (2002) Memory biases in the anxiety disorders: current status. Clin Psychol Rev, 22:587-627.
27. Coles ME, Turk CL, Heimberg RG (2007) Memory bias for threat in generalized anxiety disorder: the potential importance of stimulus relevance. Cogn Behav Ther, 36:65-73.
28. Corbetta M, Shulman GL (2002) Control of goal-directed and stimulus-driven attention in the brain. Nat Rev Neurosci, 3:201-215.
29. Craske MG, Stein MB (2016) Anxiety. Lancet 388:3048-3059.
30. Dalgleish T, Watts FN (1990) Biases of attention and memory in disorders of anxiety and depression. Clin Psychol Rev, 10:589-604.
31. Danion JM, Kauffmann-Muller F, Grangé D, Zimmermann MA, Greth P (1995) Affective valence of words, explicit and implicit memory in clinical depression. J Affect Disord, 34:227-234.
32. Deese J (1959) Influence of inter-item associative strength upon immediate free recall. Psychol Rep, 5:305-312.
33. Dehon H, Larøi F, Van der Linden M (2010) Affective valence influences participant's susceptibility to false memories and illusory recollection. Emotion, 10:627-639.
34. De Lissnyder E, Koster EH, De Raedt R (2012) Emotional interference in working memory is related to rumination. Cognit Ther Res, 36:348-357.
35. Denny EB, Hunt RR (1992) Affective valence and memory in depression: dissociation of recall and fragment completion. J Abnorm Psychol, 101:575-580.
36. Dowens M, Calvo M (2003) Genuine memory bias versus response bias in anxiety. Cogn Emot, 17:843-857.
37. D’Souza D, Avati A (2021) Memory and learning: basic concepts. In Neuro-Systemic Applications in Learning (Eds KA Thomas, JV Kureethara, S Bhattacharyya):227-240. Cham, Springer.
38. Essau CA, Lewinsohn PM, Lim JX, Moon-ho RH, Rohde P (2018) Incidence, recurrence and comorbidity of anxiety disorders in four major developmental stages. J Affect Disord, 228:248-253.
39. Everaert J, Vrijsen JN, Martin-Willett R, van de Kraats L, Joormann J (2022) A meta-analytic review of the relationship between explicit memory bias and depression: depression features an explicit memory bias that persists beyond a depressive episode. Psychol Bull, 148:435-463.
40. Eysenck MW, Byrne A (1994) Implicit memory bias, explicit memory bias, and anxiety. Cogn Emot, 8:415-431.
41. Eysenck MW, Derakshan N, Santos R, Calvo MG (2007) Anxiety and cognitive performance: Attentional control theory. Emotion, 7:336-353.
42. Eysenck MW, Derakshan N (2011) New perspectives in attentional control theory. Pers Individ Dif, 50:955-960.
43. Eysenck MW, Fajkowska M (2018) Anxiety and depression: toward overlapping and distinctive features. Cogn Emot, 32:1391-1400.
44. Faul L, LaBar KS (2023) Mood-congruent memory revisited. Psychol Rev, 130:1421-1456.
45. Flegal KE, Reuter-Lorenz PA (2014) Get the gist? The effects of processing depth on false recognition in short-term and long-term memory. Mem Cognit, 42:701-711.
46. Friedman BH, Thayer JF, Borkovec TD (2000) Explicit memory bias for threat words in generalized anxiety disorder. Behav Ther, 31:745-756.
47. Garber J, Weersing VR (2010) Comorbidity of anxiety and depression in youth: implications for treatment and prevention. Clin Psychol (New York), 17:293-306.
48. Garry M, Manning CG, Loftus EF, Sherman SJ (1996) Imagination inflation: Imagining a childhood event inflates confidence that it occurred. Psychon Bull Rev, 3:208-214.
49. Goeleven E, De Raedt R, Baert S, Koster EHW (2006) Deficient inhibition of emotional information in depression. J Affect Disord, 93:149-157.
50. Gomez-Ariza CJ, Iglesias-Parro S, Garcia-Lopez LJ, Díaz-Castela MM, Espinosa-Fernandez L, Muela JA (2013) Selective intentional forgetting in adolescents with social anxiety disorder. Psychiatry Res, 208:151-155.
51. Göz İ, Karahan SK, Tekcan Aİ (2016) Individuals with obsessive-compulsive disorder are less prone to false memories. J Obsessive Compuls Relat Disord, 10:62-68.
52. Grant DM, White EJ (2016) Influence of anxiety on cognitive control processes. In Oxford research encyclopedia of psychology. New York, Oxford University Press.
53. Gray J (2001) Emotional modulation of cognitive control: approach-withdrawal states double-dissociate spatial from verbal two-back task performance. J Exp Psychol Gen, 130:436-452.
54. Gündüz A (2007) True and false memory with emotionally valenced words: Depression, trait anxiety and personality factors (Uzmanlık tezi). Ankara, Orta Doğu Teknik Üniversitesi.
55. Freyd JJ, Gleaves DH (1996) " Remembering" words not presented in lists: relevance to the current recovered/false memory controversy. J Exp Psychol Learn Mem Cogn, 22:811-813.
56. Harper NR (2017) The relationship between worry symptoms of Generalized Anxiety Disorder and true memory, false memory, and metamemory (Uzmanlık tezi). Edwardsville, Southern Illinois University.
57. Hellenthal MV, Knott LM, Howe ML, Wilkinson S, Shah D (2019) The effects of arousal and attention on emotional false memory formation. J Mem Lang, 107:54-68.
58. Herrera S, Montorio I, Cabrera I, Botella J (2017) Memory bias for threatening information related to anxiety: an updated meta-analytic review. J Cogn Psychol, 29:832-854.
59. Hertel P (2004) Memory for emotional and nonemotional events in depression. In Memory and Emotion, (Eds D Reisberg, P Hertel):186-216. Oxford, Oxford University Press.
60. Hirschfeld RM (2001) The comorbidity of major depression and anxiety disorders: recognition and management in primary care. Prim Care Companion J Clin Psychiatry, 3:244-254.
61. Hirsch CR, Mathews A (2012) A cognitive model of pathological worry. Behav Res Ther, 50:636-646.
62. Hohls JK, König HH, Quirke E, Hajek A (2021) Anxiety, depression and quality of life—a systematic review of evidence from longitudinal observational studies. Int J Environ Res Public Health, 18:12022.
63. Howe ML (2005) Children (but not adults) can inhibit false memories. Psychol Sci, 16:927-931.
64. Howe ML, Candel I, Otgaar H, Malone C, Wimmer MC (2010) Valence and the development of immediate and long-term false memory illusions. Memory, 18:58-75.
65. Howe ML, Malone C (2011) Mood-congruent true and false memory: Effects of depression. Memory, 19:192-201.
66. Hyman IE, Husband TH, Billings FJ (1995) False memories of childhood experiences. Appl Cogn Psychol, 9:181-197.
67. Ioime L, Saraulli D, Spataro P (2014) Memory and neuropsychological dysfunctions in the generalized anxiety disorder. In New Perspectives on Generalized Anxiety Disorder, (Eds R Guglielmo, L Janiri, G Pozzi D Reisberg, P Hertel):131-147. New York, Nova Science Publishers.
68. Joormann J (2004). Attentional bias in dysphoria: The role of inhibitory processes. Cogn Emot, 18:125-147.
69. Joormann J, Yoon KL, Zetsche U (2007) Cognitive inhibition in depression. Appl Prev Psychol, 12:128-139.
70. Joormann J, Gotlib IH (2007) Selective attention to emotional faces recovering from depression. J Abnorm Psychol, 116:80-85.
71. Joormann J, Teachman BA, Gotlib IH (2009) Sadder and less accurate? False memory for negative material in depression. J Abnorm Psychol, 118:412-417.
72. Joormann J, Gotlib IH (2010) Emotion regulation in depression: relation to cognitive inhibition. Cogn Emot, 24:281-298.
73. Joshi G, Rathore T, Verma K (2025) Emotion-Induced Memory Distortions: insights from Deese-Roediger-McDermott and Misinformation Paradigms-A Comprehensive Review. Health Sci Rev, 14:100216.
74. Kapucu A, Kılıç A, Özkılıç Y, Sarıbaz B (2018) Turkish Emotional Word Norms for Arousal, Valence, and Discrete Emotion Categories. Psychol Rep, 124:188-209.
75. Kensinger EA, Corkin S (2004) The effects of emotional content and aging on false memories. Cogn Affect Behav Neurosci, 4:1-9.
76. Kensinger EA (2009) How emotion affects older adults’ memories for event details. Memory, 17:208-219.
77. Kessler RC, Bromet EJ (2013) The epidemiology of depression across cultures. Annu Rev Public Health, 34:119-138.
78. Kizilbash AH, Vanderploeg RD, Curtiss G (2002) The effects of depression and anxiety on memory performance. Arch Clin Neuropsychol, 17:57-67.
79. Knott LM, Thorley C (2014) Mood-congruent false memories persist over time. Cogn Emot, 28:903-912.
80. LeMoult J, Gotlib IH (2019) Depression: a cognitive perspective. Clin Psychol Rev, 69:51-66.
81. Leppanen JM (2006) Emotional information processing in mood disorders: a review of behavioral and neuroimaging findings. Curr Opin Psychiatry, 19:34-39.
82. Lindsay DS, Read, JD (1994) Psychotherapy and memories of childhood sexual abuse: a cognitive perspective. Appl Cogn Psychol, 8:281-338.
83. Loftus EF, Palmer JC (1974) Reconstruction of automobile destruction: an example of the interaction between language and memory. J Verbal Learning Verbal Behav, 13:585-589.
84. Loftus EF (1975) Leading questions and the eyewitness report. Cogn Psychol, 7:560-572.
85. Loftus EF, Miller DG, Burns HJ (1978) Semantic integration of verbal information into a visual memory. J Exp Psychol Hum Learn, 4:19-31.
86. Loftus EF, Pickrell JE (1995) The formation of false memories. Psychiatr Ann, 25:720-725.
87. Loftus EF (1993) The reality of repressed memories. Am Psychol, 48:518-537.
88. Loftus EF (2011) Crimes of memory: false memories and societal justice. In Psychology and the real world: essays illustrating fundamental contributions to society, (Eds MA Gernsbacher, RW Pew, LM Hough, JR Pomerantz):83-88. New York, Worth Publishers.
89. Lotterman JH, Bonanno,GA (2014) Those were the days: memory bias for the frequency of positive events, depression, and self-enhancement. Memory, 22:925-936.
90. Măirean C (2018) The role of depression and anxiety in developing true and false memories about past events. Psychol Ser, 27:61-76.
91. Maras KL, Gaigg SB, Bowler DM (2012) Memory for emotionally arousing events over time in Autism Spectrum Disorder. Emotion, 12:1118-1128.
92. Mathews A, MacLeod C (2005) Cognitive vulnerability to emotional disorders. Annu Rev Clin Psychol, 1:167-195.
93. McKendree‐Smith N, Scogin F (2000) Depressive realism: effects of depression severity and interpretation time. J Clin Psychol, 56:1601-1608.
94. Michalowski JM, Weymar M, Hamm AO (2014) Remembering the object you fear: brain potentials during recognition of spiders in spider-fearful individuals. PLoS One, 9:e109537.
95. Mineka EALS (1998) Anxiety and mood-congruent autobiographical memory: a conceptual failure to replicate. Cogn Emot, 12:625-634.
96. Moritz S, Gläscher J, Brassen S (2005) Investigation of mood‐congruent false and true memory recognition in depression. Depress Anxiety, 21:9-17.
97. Mortiz S, Voigt K, Arzola GM, Otte C (2008) When the half-full glass is appraised as half empty: mood-congruent true and false recognition in depression is modulated by salience. Memory, 16:810-820.
98. Moritz S, Schneider BC, Peth J, Arlt S, Jelinek L (2018) Metacognitive Training for Depression (D-MCT) reduces false memories in depression. A randomized controlled trial. Eur Psychiatry, 53:46-51.
99. Nichols RM, Loftus EF (2019) Who is susceptible in three false memory tasks?. Memory, 27:962-984.
100. Ost J, Blank H, Davies J, Jones G, Lambert K, Salmon K (2013) False memory ≠ false memory: DRM errors are unrelated to the misinformation effect. PloS One, 8:e57939.
101. Otgaar H, Howe ML, Peters M, Sauerland M, Raymaekers L (2013) Developmental trends in different types of spontaneous false memories: implications for the legal field. Behav Sci Law, 31:666-682.
102. Otgaar H, Muris P, Howe ML, Merckelbach H (2017) What drives false memories in psychopathology? A case for associative activation. Clin Psychol Sci, 5:1048-1069.
103. Otgaar H, Houben ST, Howe ML (2018) Methods of studying false memory. In Handbook of research methods in human memory, (Eds H Otani, BL Schwartz):238-252. London, Routledge.
104. Palmer JE, Dodson CS (2009) Investigating the mechanisms fuelling reduced false recall of emotional material. Cogn Emot, 23:238-259.
105. Pezdek K, Lam S (2007) What research paradigms have cognitive psychologists used to study “false memory,” and what are the implications of these choices? Conscious Cogn, 16:2-17.
106. Phelps EA, LaBar KS, Spencer DD (1997) Memory for emotional words following unilateral temporal lobectomy. Brain Cogn, 35:85-109.
107. Reyna VF, Brainerd CJ (1995) Fuzzy-trace theory: Some foundational issues. Learn Individ Differ, 7:145-162.
108. Rinck M, Becker ES (2005) A comparison of attentional biases and memory biases in women with social phobia and major depression. J Abnorm Psychol, 114:62-74.
109. Roberts P (2002) Vulnerability to false memory: the effects of stress, imagery, trait anxiety, and depression. Curr Psychol, 21:240-252.
110. Roediger HL, McDermott KB (1995) Creating false memories: Remembering words not presented in lists. J Exp Psychol Learn Mem Cogn, 21:803-814.
111. Roediger HL, Watson JM, McDermott KB, Gallo DA (2001) Factors that determine false recall: A multiple regression analysis. Psychon Bull Rev, 8:385-407.
112. Ruci L, Tomes JL, Zelenski JM (2009) Mood-congruent false memories in the DRM paradigm. Cogn Emot, 23:1153-1165.
113. Ruder M, Bless H (2003) Mood and the reliance on the ease of retrieval heuristic. J Pers Soc Psychol, 85:20-32.
114. Russell JA (1980) A circumplex model of affect. J Pers Soc Psychol, 39:1161-1178.
115. Sharkawy JE, Groth K, Vetter C, Beraldi A, Fast K (2008) False memories of emotional and neutral words. Behav Neurol, 19:7-11.
116. Storbeck J, Clore GL (2005) With sadness comes accuracy; with happiness, false memory: mood and the false memory effect. Psychol Sci, 16:785-791.
117. Toffalini E, Mirandola C, Drabik MJ, Melinder A, Cornoldi C (2014) Emotional negative events do not protect against false memories in young adults with depressive–anxious personality traits. Pers Individ Dif, 66:14-18.
118. Toffalini E, Mirandola C, Coli T, Cornoldi C (2015) High trait anxiety increases inferential false memories for negative (but not positive) emotional events. Pers Individ Dif, 75:201-204.
119. Tulving, E. (1985). Memory and consciousness. Can Psychol, 26:1-12.
120. Watkins E, Teasdale JD (2001) Rumination and overgeneral memory in depression: effects of self-focus and analytic thinking. J Abnorm Psychol, 110:353-357.
121. Watkins E, Moulds M, Mackintosh B (2005) Comparisons between rumination and worry in a non-clinical population. Behav Res Ther, 43:1577-1585.
122. Watkins E, Moberly NJ, Moulds ML (2008) Processing mode causally influences emotional reactivity: distinct effects of abstract versus concrete construal on emotional response. Emotion, 8:364-378.
123. Wenzel A, Jostad C, Brendle JR, Ferraro FR, Lystad CM (2004). An investigation of false memories in anxious and fearful individuals. Behav Cogn Psychother, 32:257-274.
124. Wilmer MT, Anderson K, Reynolds M (2021). Correlates of quality of life in anxiety disorders: review of recent research. Curr Psychiatry Rep, 23:1-9.
125. Wootan SS, Leding JK (2015) Need for cognition and false memory: can one’s natural processing style be manipulated by external factors?. Am J Psychol, 128:459-468.
126. Yeh ZT, Hua MS (2009) Effects of depressive disorder on false memory for emotional information. Depress Anxiety, 26:456-463.
127. Yin H, Zhou Y, Li Z (2024) Contradictory findings in the study of emotional false memory: a review on the inadvisability of controlling valence and arousal. Front Psychol, 15:1380742.
128. Yu Q, Zhuang Q, Wang B, Liu X, Zhao G, Zhang M (2018) The effect of anxiety on emotional recognition: evidence from an ERP study. Sci Rep, 8:16146.
129. Yüvrük E, Turan H, Kapucu A (2019) Duygu içerikli sözcüklerden oluşan Türkçe DRM listelerinin geliştirilmesi. Psikoloji Çalışmaları, 39:245-266.
130. Zhang W (2017) The effect of emotion on false memories in the Deese-Roediger-McDermott (DRM) paradigm (Doctoral thesis). Otago, University of Otago.
131. Zhang W, Gross J, Hayne H (2017) The effect of mood on false memory for emotional DRM word lists. Cogn Emot, 31:526-537.
132. Zhang W, Cowan G, Colombo M, Gross J, Hayne H (2021). Emotional content of the event but not mood influences false memory. Appl Cogn Psychol, 35:1418-1426.