Mapping Trauma-Related Psychiatric Genetics: A Bibliometric Study on Gene, Epigenetic and Resilience

Öz

Objective: This study explored the development of research in the genetics and epigenetics of trauma-related psychiatric outcomes, delineating the journals, institutions, countries and research themes that have characterized the literature. Method: We performed a search in the Web of Science Core Collection for publications with search terms related to chosen hypothalamic-pituitary-adrenal (HPA)-axis genes, genetic and epigenetic mechanisms, and trauma-related outcomes. The final dataset consisted of 863 publications. Biblioshiny was used to characterize publication patterns and research performance; VOSviewer was used to visualize co-citation relationships, international collaboration, keyword co-occurrence, and influential sources. Results: The USA had the highest number of publications followed by Germany, China and the Netherlands. The number of citations increased significantly after 2015 The analysis of collaboration revealed strong ties between European countries, with more recent input from Asia. Changes in keyword patterns also pointed to a broader thematic change. Recent work has increasingly incorporated epigenetics, resilience, and social support. Conclusion: The literature on psychiatric outcomes of trauma has expanded from a narrow focus on genetic susceptibility to include epigenetic regulation, neurobiological processes, and resilience.

Anahtar Kelimeler

• Post-traumatic stress disorder (PTSD)
• Resilience
• Epigenetics
• HPA-axis genes
• Bibliometric analysis

Travma ile İlişkili Psikiyatrik Genetik Haritalama: Gen, Epigenetik ve Dayanıklılık Üzerine Bibliyometrik bir Çalışma

Öz

Amaç: Bu çalışma, travmayla ilişkili psikiyatrik sonuçların genetiği ve epigenetiğine yönelik araştırmaların kapsamlı bir bibliyometrik analizini gerçekleştirmeyi; temel dergiler, kurumlar, ülkeler ve güncel araştırma konularına odaklanmayı amaçlamıştır. Yöntem: Veriler, seçilmiş hipotalamus-hipofiz-adrenal (HPA) ekseni genleri, genetik ve epigenetik mekanizmalar ve travmayla ilişkili sonuçlarla ilgili anahtar kelimeler kullanılarak Web of Science Core Collection veri tabanından elde edilmiştir. Toplam 863 yayın analiz edilmiştir. Tanımlayıcı analizler için Biblioshiny kullanılırken, ortak atıf örüntüleri, iş birlikleri, anahtar kelime eş-oluşumları ve temel kaynaklara ilişkin ağ görselleştirmelerinin oluşturulmasında VOSviewer kullanılmıştır. Bulgular: Yayınların ülkelere göre dağılımı incelendiğinde, Amerika Birleşik Devletleri ilk sırada yer alırken Almanya, Çin ve Hollanda onu izlemektedir. Atıf sayılarında özellikle 2015 sonrasında belirgin bir yükseliş gözlenmiştir. Ülkeler arası iş birliği açısından Avrupa’daki güçlü bağlantılar dikkat çekerken, Asya kaynaklı bilimsel katkının daha yakın dönemde arttığı görülmektedir. Anahtar kelimelerdeki değişim de araştırma gündemindeki dönüşümü yansıtmaktadır. Son dönemde epigenetik ve psikolojik sağlamlığın yanı sıra sosyal desteği de içeren daha geniş temalara doğru bir yönelim gözlenmiştir. Sonuç: Bulgular, travmayla ilişkili psikiyatrik sonuçlar üzerine gelişen literatürün genetik yatkınlıkla sınırlı kalmadığını; epigenetik düzenleme, nörobiyolojik süreçler ve psikolojik sağlamlık gibi farklı araştırma eksenlerini de kapsadığını göstermektedir.

Anahtar Kelimeler

• Travma sonrası stres bozukluğu (TSSB)
• Dayanıklılık
• Epigenetik
• HPA ekseni genleri
• Bibliyometrik analiz

Kaynakça

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