Ketamin: Yeni Bir Antidepresan?

Yıl 2015, Cilt: 7 Sayı: 1, 30 - 40, 01.03.2015

Feride Karacaer

https://doi.org/10.5455/cap.20140430125304

Öz

Major depresif bozukluğu olan bir çok hastada standart antidepresanlara ihtiyaç duyulmaktadır. Ancak tedavi edici etkilerin ortaya çıkması için haftalar gerektiğinden yeterli yanıt alınamamaktadır. Son çalışmalar subanestezik dozlardaki ketaminin depresyon tedavisinde etkin ve güvenilir olduğunu göstermiştir. Ketaminin antidepresan etkilerinin kısa süreli olduğu görülmüştür ve psikomimetik yan etkileri depresif hastalarda kullanımını kısıtlayabilir. Gelecekte yapılacak çalışmaların yanıtı belirleyecek faktörlere (klinik ve farmakolojik olarak), farklı doz uygulamalarının ve uygulama yollarının araştırılmasına ve antidepresan etkinin sürdürülmesine odaklanması gerekmektedir.

Anahtar Kelimeler

Ketamin, major depresif bozukluk

Ketamine: A New Antidepressant?

Öz

Standart antidepressants are needed for the many individuals with major depressive disorder. However they do not respond adequately to treatment and because of a delay of weeks before the emergence of therapeutic effects. Recent studies show that subanesthetic dose of ketamine is efficacy and safety for the treatment of depression. Antidepressant effects of ketamine have been found to be short-lived and its psychotomimetic properties may limit the use of ketamine to depressive patients. Future research studies should focus on identifying predictors of response (pharmalogical and clinical) , investigating application of different doses and routes of administration and maintaining antidepressant effect.

Anahtar Kelimeler

Ketamine, major depressive disorder

Kaynakça

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• Feride Karacer, Uz.Dr., Çukurova Üniversitesi Tıp Fakültesi Anesteziyoloji ve Reanimasyon ABD, Adana.