Yıl 2021, Cilt 13 , Sayı 1, Sayfalar 109 - 125 2021-03-31

Immunotherapy in Opioid Use Disorders
Opioid Kullanım Bozukluklarında İmmünoterapi

Bahadır GENİŞ [1] , Hakan AKSU [2] , Zehra ARIKAN [3]


Opioid use disorders are a deadly problem worldwide. Pharmacological therapies are effective for abstinence but remain inadequate in the treatment of addiction. Immunotherapy is a promising treatment modality in opioid use disorders. Immunotherapy aims to detect and capture substances by antibodies. Specific antibodies generated against substances bind a psychoactive substance and prevent them from passing through the blood/brain barrier. The psychoactive substance, which cannot pass through the blood brain barrier, will not be able to reveal both the euphoria effect and its side effects such as respiratory depression. Pre-clinical studies are partially sufficient in terms of effectiveness and reliability. However, long term high antibody levels could not be obtained in the blood following the vaccinations. The number of studies on opioid vaccines that have reached the clinical research level is very low. Thus, the effect of matter in the brain is prevented from occurring. Although effective results were obtained in preclinical studies, long-term high antibody levels could not be achieved in the blood. The number of studies that have reached the level of clinical research is insufficient. Efforts to increase the effectiveness of vaccines are ongoing. Although positive results are obtained in these studies, there are some difficulties vaccination studies. The financial burden of vaccine development, the use of multiple substances in opioid dependents, immune system suppression by the opioids, and changes in the degree of opioid purity are some of them. Despite all these difficulties, immunotherapy is the treatment that the researchers and patients expect with hope.
Opioid kullanım bozuklukları dünya çapında ölümcül bir sorundur. Farmakolojik tedaviler yoksunluk için etkilidir, ancak bağımlılığın tedavisinde yetersiz kalmaktadır. İmmünoterapi, opioid kullanım bozukluklarında umut verici bir tedavi yöntemidir. İmmünoterapi, antikorlarla maddeleri tespit etmeyi ve yakalamayı amaçlamaktadır. Maddelere karşı üretilen spesifik antikorlar psikoaktif bir maddeye bağlanır ve kan / beyin bariyerinden geçmelerini önler. Kan beyin bariyerini geçemeyen psikoaktif madde hem öfori etkisini hem de solunum depresyonu gibi yan etkilerini ortaya koyamayacaktır. Klinik öncesi çalışmalar etkinlik ve güvenilirlik açısından kısmen yeterlidir. Bununla birlikte, aşıları takiben kanda uzun süreli yüksek antikor seviyeleri elde edilememiştir. Klinik araştırma düzeyine ulaşmış olan opioid aşıları ile ilgili çalışma sayısı çok düşüktür. Aşıların etkinliğini artırma çabaları devam etmektedir. Bu çalışmalarda olumlu sonuçlar alınmasına rağmen aşılama çalışmalarında bazı zorluklar bulunmaktadır. Aşı gelişiminin mali yükü, opioid bağımlılarında çoklu maddelerin kullanımı, opioidlerin bağışıklık sistemi baskılanması ve opioid saflık derecesindeki değişiklikler bunlardan bazılarıdır. Tüm bu zorluklara rağmen, immünoterapi araştırmacıların ve hastaların umutla bekledikleri tedavidir.
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Birincil Dil tr
Konular Psikiyatri
Bölüm Derleme
Yazarlar

Orcid: 0000-0001-8541-7670
Yazar: Bahadır GENİŞ
Kurum: ZONGULDAK ÇAYCUMA DEVLET HASTANESİ
Ülke: Turkey


Orcid: 0000-0003-2930-5337
Yazar: Hakan AKSU (Sorumlu Yazar)
Kurum: BARTIN DEVLET HASTANESİ
Ülke: Turkey


Orcid: 0000-0003-3138-2315
Yazar: Zehra ARIKAN
Kurum: GAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ
Ülke: Turkey


Tarihler

Kabul Tarihi : 5 Eylül 2020
Yayımlanma Tarihi : 31 Mart 2021

Bibtex @derleme { pgy738689, journal = {Psikiyatride Güncel Yaklaşımlar}, issn = {1309-0658}, eissn = {1309-0674}, address = {}, publisher = {Lut TAMAM}, year = {2021}, volume = {13}, pages = {109 - 125}, doi = {10.18863/pgy.738689}, title = {Opioid Kullanım Bozukluklarında İmmünoterapi}, key = {cite}, author = {Geniş, Bahadır and Aksu, Hakan and Arıkan, Zehra} }
APA Geniş, B , Aksu, H , Arıkan, Z . (2021). Opioid Kullanım Bozukluklarında İmmünoterapi . Psikiyatride Güncel Yaklaşımlar , 13 (1) , 109-125 . DOI: 10.18863/pgy.738689
MLA Geniş, B , Aksu, H , Arıkan, Z . "Opioid Kullanım Bozukluklarında İmmünoterapi" . Psikiyatride Güncel Yaklaşımlar 13 (2021 ): 109-125 <https://dergipark.org.tr/tr/pub/pgy/issue/58188/738689>
Chicago Geniş, B , Aksu, H , Arıkan, Z . "Opioid Kullanım Bozukluklarında İmmünoterapi". Psikiyatride Güncel Yaklaşımlar 13 (2021 ): 109-125
RIS TY - JOUR T1 - Opioid Kullanım Bozukluklarında İmmünoterapi AU - Bahadır Geniş , Hakan Aksu , Zehra Arıkan Y1 - 2021 PY - 2021 N1 - doi: 10.18863/pgy.738689 DO - 10.18863/pgy.738689 T2 - Psikiyatride Güncel Yaklaşımlar JF - Journal JO - JOR SP - 109 EP - 125 VL - 13 IS - 1 SN - 1309-0658-1309-0674 M3 - doi: 10.18863/pgy.738689 UR - https://doi.org/10.18863/pgy.738689 Y2 - 2020 ER -
EndNote %0 Psikiyatride Güncel Yaklaşımlar Opioid Kullanım Bozukluklarında İmmünoterapi %A Bahadır Geniş , Hakan Aksu , Zehra Arıkan %T Opioid Kullanım Bozukluklarında İmmünoterapi %D 2021 %J Psikiyatride Güncel Yaklaşımlar %P 1309-0658-1309-0674 %V 13 %N 1 %R doi: 10.18863/pgy.738689 %U 10.18863/pgy.738689
ISNAD Geniş, Bahadır , Aksu, Hakan , Arıkan, Zehra . "Opioid Kullanım Bozukluklarında İmmünoterapi". Psikiyatride Güncel Yaklaşımlar 13 / 1 (Mart 2021): 109-125 . https://doi.org/10.18863/pgy.738689
AMA Geniş B , Aksu H , Arıkan Z . Opioid Kullanım Bozukluklarında İmmünoterapi. pgy. 2021; 13(1): 109-125.
Vancouver Geniş B , Aksu H , Arıkan Z . Opioid Kullanım Bozukluklarında İmmünoterapi. Psikiyatride Güncel Yaklaşımlar. 2021; 13(1): 109-125.
IEEE B. Geniş , H. Aksu ve Z. Arıkan , "Opioid Kullanım Bozukluklarında İmmünoterapi", Psikiyatride Güncel Yaklaşımlar, c. 13, sayı. 1, ss. 109-125, Mar. 2021, doi:10.18863/pgy.738689