Parotid Adenoid Cystic Carcinoma Metastasizing to the Liver: A Case Report

Yıl 2021, , 46 - 48, 01.03.2021

Hatice Karaman , Arzu Tasdemir , İpek Özer , Merve Doğan

https://doi.org/10.38175/phnx.832035

Öz

Adenoid cystic carcinoma is a rare malignant neoplasm of the salivary gland. Salivary gland neoplasms constitute 3% of cancers of all sites, of which, 10–15% are malignant. Though adenoid cystic carcinoma is the most common malignant tumor of the submandibular, sublingual and minor salivary glands, it accounts for only 15% of parotid cancers. They are generally slow-growing and spread relentlessly to adjacent structures. Hematogenous spread is more common than lymphatic spread, the common sites of metastasis being the lung, bone, liver, and brain. We present a case of multiple liver metastases occurring 3 years after surgery for adenoid cystic carcinoma of the parotid gland.
The primary therapy, metastasis, and outcome of adenoid cystic carcinoma are discussed.

Anahtar Kelimeler

Adenoid cystic carcinoma, parotid;, liver

Karaciğere Metastaz Yapan Parotis Adenoid Kistik Karsinomu: Bir Olgu Sunumu

Öz

Adenoid kistik karsinom tükrük bezinin nadir görülen malign bir tümörüdür. Tükrük bezi neoplazileri tüm kanserlerin %3’ünü oluşturur ve bunların %10-15’i maligndir. Aynı zamanda adenoid kistik karsinom submandibuler, sublingual ve minör tükrük bezlerinin en sık malign tümörüdür. Parotis kanserlerinin sadece %15’ini oluşturur. Bunlar genel olarak yavaş büyür ve çevre dokuya agresif yayılır. Hematojen yayılma, lenfatik yayılmadan daha yaygındır, yaygın metastaz bölgeleri akciğer, kemik, karaciğer ve beyindir. Parotis bezinde adenoid kistik karsinom olan ve ameliyattan 3 yıl sonra multiple karaciğer metastazları görülen vakayı sunduk. Adenoid kistik karsinomun birincil tedavisi, metastazı ve sonucu tartışılmaktadır

Anahtar Kelimeler

Adenoid kistik karsinom;, parotis;, karaciğer

Kaynakça

• Cockerill CC, Daram S, El-Naggar AK, Hanna EY, Weber RS, Kupferman ME. Primary sarcomas of the salivary glands: case series and literature review. Head Neck. 2013;35(11):1551-1557. DOI: 10.1002/hed.23203.
• Ishida E, Ogawa T, Rokugo M, Ishikawa T, Wakamori S, Ohkoshi A, et al. Management of adenoid cystic carcinoma of the head and neck: a single-institute study with over 25-year follow-up. Head Face Med. 2020;16(1):14. DOI: 10.1186/s13005-020-00226-2.
• Seethala RR. Salivary Gland Tumors: Current Concepts and Controversies. Surg Pathol Clin. 2017;10(1):155-176. DOI: 10.1016/j.path.2016.11.004.
• International Head and Neck Scientific Group. Cervical lymph node metastasis in adenoid cystic carcinoma of the major salivary glands. J Laryngol Otol. 2017;131(2):96-105. DOI: 10.1017/S0022215116009749.
• Rafael OC, Paul D, Chen S, Kraus D. Adenoid cystic carcinoma of submandibular gland metastatic to great toes: case report and literature review. Clin Case Rep. 2016;4(8):820-823. DOI: 10.1002/ccr3.635.
• Yurut-Caloglu V, Caloglu M, Ozyilmaz F, Saynak M, Cosar-Alas R, Karagol H, et al. Lung, bone, skeletal muscles and cutaneous metastases from adenoid cystic carcinoma of the parotid gland: a case report and review of the literature. Med Oncol. 2007;24(4):458-462. DOI: 10.1007/s12032-007-0016-x.
• Dutta A, Arun P, Arun I. Adenoid cystic carcinoma with transformation to high grade carcinomatous and sarcomatoid components: A Rare Case Report with Review of Literature. Head Neck Pathol. 2020;14(4):1094-1104. DOI: 10.1007/s12105-019-01120-3.
• Umeda M, Nishimatsu N, Masago H, Ishida Y, Yokoo S, Fujioka M, et al. Tumor-doubling time and onset of pulmonary metastasis from adenoid cystic carcinoma of the salivary gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;88:473–478.
• Sung MW, Kim KH, Kim JW, Min YG, Seong WJ, Roh JL, et al. Clinicopathologic predictors and impact of distant metastasis from adenoid cystic carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg. 2003;129:1193–1197. DOI: 10.1001/archotol.129.11.1193
• Mehrotra R, Singh M. Diagnosis of hepatic metastasis of adenoid cystic carcinoma of the salivary gland by fine needle aspiration. Cytopathology. 1999;10:216–217. DOI: 10.1046/j.1365-2303.1999.0157a.x.